N-Ethylpentedrone Synthesis

G.Patton

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@Rua Hello, if you want to get NEP hydrochloride salt powder or crystals, you need you use HCl gas or HCl acid anyway.
 

Rua

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Ethylmine aqueous solution cas no ??
 
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Hello. Are the proportions shown correct? 1KG
● 2 bromovalerophenone ~770 ml
● ethylamine ~640 ml
 

طهرانmobster

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I realy like n_ethylpendotrone
Today i cook again
Have some problem with yield but quality is amazing
 

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should

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General, is NEP similar to methamphetamine, in terms of taste and the high it produces?
 

A5kL3Pi0s

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no I wouldnt say so.. Maybe more like a mixture between "softer" meth and something like crack/cocaine freebase.
But overall NEP is less euphoric and smoother when compared to other cathinones/pyrovalerones or even meth, but Ive heard totally different experiences also, so I guess only way to find out is trying...
 

r3n1

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Compared to other Cathinones the euphoria felt for me a bit more entactogen Esque then the other "bigger" Ones.. Softer ethyl hexedrone with sight 3mmc or even 4mmc touch... Just a slight! So imo it's a perfect party drug! The stronger Cathinones get to close to dopamine insanity lol nep seems to push out more serotonin at least it kinda felt like. That for me cheers and the softer meth comparising is fitting as well!
 

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NEP (=NEPD) more serotonergic? Thats just wrong, theres a few papers looking at NEPD (and analogs) affinities.
The DAT/SERT Ratio of NEPD speaks volumes...
So NEP(D) is almost exclusivly a DRI, minimal SERT inhibition 🤷‍♂️
 

should

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Hello sir, how do I handle the powdered form of 2-Bromovalerophenone?
 

A5kL3Pi0s

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Id start by dissolving it, for everything else follow the procedure as stated in the original post.
Although you intruiged me: powdered 2BV? we've been using liquid Valerophenone or 2BV pretty much exclusivly, never even saw powder being offered somewhere - also what would be the benefit of using powder over liquid 2BV?
 

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Im not quite sure I understand: You sell 2BV? Why do you ask how to handle it then?
If its powdered dissolve it in the solvent used in the synthesis and re-calculate the proportions maybe - Im not exactly sure, but if you size up the reaction and dissolve the 2BV in a different solvent (which doesnt interfere with the rest of the synthesis negativly) that might be a possibility aswell.
 

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2-b-valerophenone is a liquid. It can't be a solid. it's possible you have the salt of 2-bv in powder form, otherwise it's not 2-bv
 

r3n1

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Any one has experience in doing the bromination with BCDMH (bromo chloro dimethylhydantion) which is simple otc available pool bromine!
 

A5kL3Pi0s

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there is a thread on this afaik, but I gotta say, HBr 48% is available otc in europe so never really went deep into the brom "extraction" type stuff. Just keep possible toxicity in mind, Br can inflict alot of harm on you faster than one mjght think...
 

JJmadrid

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Instead 37.32g ethylamine, can I use 3732g?
Instead 72.34g 1-phenyl-2-bromopentan-1-one, can i use 7.234 kg in a 20L flask?
Or scaling like that is dangerous and I will get an explosion or fire?
 

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not more dangerous than the described procedure, likely just wasteful 🤷‍♂️

scaling syntheses up by large factors usually leads to suboptimal efficiency, though every reaction would need to be considered individually while also taking account of the available lab setup (reaction vessels, vacuum etc)
 

Osmosis Vanderwaal

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Its definitely more dangerous. 1000x more dangerous, I surmise ( see what I did there?) A large vessel and mass like you are talking, is harder to cool and easier to run away, and if you spill 37g of 2-b-v, it's bad but I you spill 3700g, you won't be able to get within 50 yards of it and they'll have to call hazmat. At the end of the day, it's reaction dependant, but insufficient cooling and exceeding the vessel are the major problems , followed by gassing yourself so hard you can't get back to it, which causes problem 1 and 2. to go 1000x is insanely too big a ramp up and you should ramp up 10x, then 100x first AT LEAST
 
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A5kL3Pi0s

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where exactly would you need to cool the reaction? Also I assumed that someone who talks about 20L scale would use a proper jacketed 20L reactor, not a steel pot used for cooking noodles or smth lmao
Also 2BV is slightly caustic, but more imoportantly a known carcinogen - especially 2BV vapour!
Btw, Ethylamine fumes are irritating to the lungs and lead to acute respiratory toxicity and major difficulty breathing. Ethyl Acetate is pretty benign, HCl.... well dont breath gaseous HCl and you shoud be fine, we're talking about fuming HCl, but again: Somone planning on doing a 20L reaction would have a proper full face respirator 🤷‍♂️ (or so one woud assume)
 

A5kL3Pi0s

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generally speaking though, when it comes to scaling procedures, Im totally with you on every point made ;)
 

JJmadrid

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Thanks to remember about using a mask since 2BV is carcinogen.
Necessary use ventilation with carbon filter, use a mask and be careful to not spill the glass flask.

I thought ethylamine was flammable, but because ethylamine is bought mixed with water no risk of fire in this synthesis. Am I correct, any possibility get an explosion or fire doing this?
 

A5kL3Pi0s

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oh no its still EXTREMELY flammable, I just didnt mention that because the thought of someone using any sort of ligher/flame during this synthesis didnt cross my mind 🤷‍♂️
But you're right, shouldve mentioned it.
A few facts on Ethylamine I can think rn:
avoid fire - Carbon and Nitrogen oxides form during combustion
avoid Nickel, Copper and Zinc - as well as strong oxidising agents genereally
Signs of exposure would be eye irritation, shortness of breath, nausea, cough, burning on skin that came in contact with the irritant.
Inhalation should be avoided, harmful to the liver and kidneys if swallowed.
Strore it in tightly closed bottles in a cool place.
Oh and regarding fire again: I hope everyone knows this already anyways but: DONT SMOKE near it or in the lab generally.
Stay safe
A5kL3Pi0s
 
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