Need help making sense of amphetamine analysis on GC/MS

rhubarb

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Hello all.

I am not a chemist of any kind so my understanding of all of this is extremely basic. Please bear with me.
I have access to a lab where I can run samples on GC/MS. Three different amphetamine samples have yielded almost identical results with a small amphetamine peak and a large caffeine peak. I'm starting to suspect something is off here with regards to the ratios.
For one: based on the peaks, the ratio is always roughly 20/80% amp to caffeine. Ingesting 20mg of such a mixture should yield no effects, yet it does. Acetone washing also does not result in a massive loss.

It does not seem to matter whether the sample is injected as the (presumed) salt, or freebased first. How should I go about testing it again? I have pure anhydrous caffeine as well and I'm thinking this could be used as a calibration reference somehow before I run another sample but I wanted to rule out any other factors, such as certain expected behavior of both compounds under these conditions. Thanks!
 

G.Patton

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Hello, you have to place a sample into a flask and add there non-polar solvent like DCM or TCM. Then, add there alkiline solution to make free base. Than, remove water layer and inject sample in your injector of GC-MS. Read my post about GC-MS. GC-MS methods for drugs

Salt form may spoil your MS detector and column, do not inject this form.

20/80% amph/caffeine can cause psychoactive effects.
 
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