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Synthesis of synthetic cathinones

Marvin "Popcorn" Sutton

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The chemical synthesis of cathinones is facile and usually follows a two-step process. Typically, the initial synthesis is of an α-bromoketone (from the prerequisite arylketone) followed by a nucleophilic substitution with an appropriate amine to give the corresponding freebase of the cathinone. Due to the instability of the free- base, the cathinones are conveniently isolated as their corresponding hydrochloride or hydrobromide salts. This method could be adapted for the synthesis of a wide range of cathinones as shown in spoilers.
Ephedrone (CAS: 5650-44-2, C10H13NOH, 2-(methylamino)-1-phenylpropan-1-one, methcathinone, MetCat) is a short-acting stimulant that produces effects similar to those from chewing the leaves of the Khat plant. The precursor is propiophenone CAS: 93-55-0.
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Flephedrone (CAS: 7598-35-7, C10H13ClFNO, 1-(4-fluorophenyl)-2-(methylamino)propan-1-one, 4-fluoromethcathinone or 4-FMC) is a central nervous system stimulant belonging to the amphetamines and cathinones class. The precursor is 4'-fluoropropiophenone CAS: 456-03-1.
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Mephedrone (CAS: 1189805-46-6, C11H15NO, 1-Propanone, 2-(methylamino)-1-(4-methylphenyl)-, 2-(Methylamino)-1-(4-methylphenyl)-1-propanone, 2-Methylamino-1-p-tolylpropane-1-one, 4MMC, Meow meow, meph). Euphoretic, is widespread. Its effects have been compared to those of cocaine, methamphetamine and ecstasy. Precursor: 4'-Methylpropiophenone (CAS: 5337-93-9).
Example: http://bbzzzsvqcrqtki6umym6itiixfhn...-mephedrone-bromination-in-dichormethane.227/
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Methedrone (CAS:530-54-1, C11H15NO2, para-methoxymethcathinone, 4-methoxymethcathinone, bk-PMMA, PMMC, methoxyphedrine, 4-MeOMC). A substance in the class of amphetamines and cathinones. Chemically, methedrone is closely related to para-methoxymethamphetamine (PMMA), methylone and mephedrone. Precursor: 4'-Methoxypropiophenone (CAS: 121-97-1).
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Methylone (CAS:186028-79-5, C11H13NO3, 3,4-methylenedioxy-N-methylcathinone, MDMC, βk-MDMA, M1). Methylone is a substituted cathinone analogue of MDMA and a 3,4-methylenedioxy analogue of methcathinone. The only structural difference between methylone and MDMA is the substitution of 2 hydrogen atoms for 1 oxygen atom in the β-position of the phenethylamine nucleus, forming a ketone group. The effects may be superior to MDMA. Precursor: 3,4-methylenedioxypropiophenone (CAS: 28281-49-4).
Example:
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α-Pyrrolidinopentiophenone (CAS: 14530-33-7, C15H21NO, α-pyrrolidinovalerophenone, α-PVP, O-2387, β-keto-prolintane, prolintanone, or desmethylpyrovalerone) is a synthetic stimulant of the cathinone class. Precursor: valerophenone (CAS: 1009-14-9).
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MDPV (CAS: 687603-66-3, C16H21NO3, 3,4-Methylenedioxypyrovalerone, methylenedioxypyrovalerone) acts as a powerful stimulant and causes effects similar to those of cocaine, methylphenidate and amphetamines. Causes irresistible craving for repeated taking. Typical doses range from 5-20 mg.
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As can be seen from the diagrams above, the synthesis of cathinones is simple. The production of large amounts is quite easy to arrange, so they come out cheap to produce.
 

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HIGGS BOSSON

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The class of methcathinones is the most promising direction in the modern drug market. The simplicity of synthesis opens up limitless possibilities for production in artisanal conditions, and the pharmacological activity of some variants, such as mephedrone, is simply amazing. All methcatinons are synthesized by one method. Choosing the necessary primary source - propiophenone, you can get substances of different properties.

Synthesis is easily scalable, unlike amphetamines. The availability and cheapness of the primary source makes the cost of the final product fantastically low. The average price of 4-methylpropiophenone in China is $50 per kilogram. With all the other costs for reagents, you can achieve a cost of $ 150-200 per kilogram of finished mephedrone in crystals. In the days of the legality of designer drugs, it was possible to produce a substance from the methcathinone class legal for one's country without changing the synthesis technology. Now it is possible only in Africa that loopholes in the laws remain, but in most civilized countries all metcathinons are banned.

But reagents for synthesis are legal, and even if some propiophenons are banned, you can always slightly modify the substance produced, for example: 4-MMC can be replaced with 3-MMC by replacing 4-methylpropiophenone to 3-methylpropiophenone. Or replacing 4-MMC with 4-FMC, replacing primary 4-methylpropiophenone to 4-fluoropropionphenone. In addition to changing the position of the benzene ring substituents, longer chains, such as butyrophenone or valerophenone, can be used. The latter has other properties, and is well suited for the synthesis of pyrrovalerones: a-PVP and MDPV.

If you have difficulty buying methylamine to synthesize mephedrone, then this problem can be circumvented by using legal ethylamine to produce 4-EMC, a substance with a very similar euphoric effect. In fact, from the class of methcathinones, it is possible to synthesize any substances in action, based on the availability of reagents and market needs: euphoretics and stimulants for every taste, from soft fluoromethcatinones to very hard a-PVP.

Such simplicity of synthesis and availability of reagents open up huge opportunities for capturing the market - competition with classic substances: cocaine, methamphetamine and MDMA, which are much more difficult to produce.

It is important to note one useful physical property of methcathinones - the ease of obtaining crystals. Hydrochlorides are well crystallized, as well as hydrobromides.

I have been producing various methcathinones for 15 years, many of which I have biotested personally for research purposes. If anyone has questions about synthesis, the choice of substance, the availability of reagents, then I will gladly share my experience.
 

Hans-Dietrich

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There are still not enough combinations where pyrrolidine instead of methylamine and vice versa.
 

Montecristo

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The class of methcathinones is the most promising direction in the modern drug market. The simplicity of synthesis opens up limitless possibilities for production in artisanal conditions, and the pharmacological activity of some variants, such as mephedrone, is simply amazing. All methcatinons are synthesized by one method. Choosing the necessary primary source - propiophenone, you can get substances of different properties.

Synthesis is easily scalable, unlike amphetamines. The availability and cheapness of the primary source makes the cost of the final product fantastically low. The average price of 4-methylpropiophenone in China is $50 per kilogram. With all the other costs for reagents, you can achieve a cost of $ 150-200 per kilogram of finished mephedrone in crystals. In the days of the legality of designer drugs, it was possible to produce a substance from the methcathinone class legal for one's country without changing the synthesis technology. Now it is possible only in Africa that loopholes in the laws remain, but in most civilized countries all metcathinons are banned.

But reagents for synthesis are legal, and even if some propiophenons are banned, you can always slightly modify the substance produced, for example: 4-MMC can be replaced with 3-MMC by replacing 4-methylpropiophenone to 3-methylpropiophenone. Or replacing 4-MMC with 4-FMC, replacing primary 4-methylpropiophenone to 4-fluoropropionphenone. In addition to changing the position of the benzene ring substituents, longer chains, such as butyrophenone or valerophenone, can be used. The latter has other properties, and is well suited for the synthesis of pyrrovalerones: a-PVP and MDPV.

If you have difficulty buying methylamine to synthesize mephedrone, then this problem can be circumvented by using legal ethylamine to produce 4-EMC, a substance with a very similar euphoric effect. In fact, from the class of methcathinones, it is possible to synthesize any substances in action, based on the availability of reagents and market needs: euphoretics and stimulants for every taste, from soft fluoromethcatinones to very hard a-PVP.

Such simplicity of synthesis and availability of reagents open up huge opportunities for capturing the market - competition with classic substances: cocaine, methamphetamine and MDMA, which are much more difficult to produce.

It is important to note one useful physical property of methcathinones - the ease of obtaining crystals. Hydrochlorides are well crystallized, as well as hydrobromides.

I have been producing various methcathinones for 15 years, many of which I have biotested personally for research purposes. If anyone has questions about synthesis, the choice of substance, the availability of reagents, then I will gladly share my experience.
Would be interesting to see a good starting point for mephedrone via methylamine.
Thanks!
 

BHBlueberry

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I don't know if you already noticed but cocaine is also a ketone but with the enormous tail ;)
 

vig212

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The class of methcathinones is the most promising direction in the modern drug market. The simplicity of synthesis opens up limitless possibilities for production in artisanal conditions, and the pharmacological activity of some variants, such as mephedrone, is simply amazing. All methcatinons are synthesized by one method. Choosing the necessary primary source - propiophenone, you can get substances of different properties.

Synthesis is easily scalable, unlike amphetamines. The availability and cheapness of the primary source makes the cost of the final product fantastically low. The average price of 4-methylpropiophenone in China is $50 per kilogram. With all the other costs for reagents, you can achieve a cost of $ 150-200 per kilogram of finished mephedrone in crystals. In the days of the legality of designer drugs, it was possible to produce a substance from the methcathinone class legal for one's country without changing the synthesis technology. Now it is possible only in Africa that loopholes in the laws remain, but in most civilized countries all metcathinons are banned.

But reagents for synthesis are legal, and even if some propiophenons are banned, you can always slightly modify the substance produced, for example: 4-MMC can be replaced with 3-MMC by replacing 4-methylpropiophenone to 3-methylpropiophenone. Or replacing 4-MMC with 4-FMC, replacing primary 4-methylpropiophenone to 4-fluoropropionphenone. In addition to changing the position of the benzene ring substituents, longer chains, such as butyrophenone or valerophenone, can be used. The latter has other properties, and is well suited for the synthesis of pyrrovalerones: a-PVP and MDPV.

If you have difficulty buying methylamine to synthesize mephedrone, then this problem can be circumvented by using legal ethylamine to produce 4-EMC, a substance with a very similar euphoric effect. In fact, from the class of methcathinones, it is possible to synthesize any substances in action, based on the availability of reagents and market needs: euphoretics and stimulants for every taste, from soft fluoromethcatinones to very hard a-PVP.

Such simplicity of synthesis and availability of reagents open up huge opportunities for capturing the market - competition with classic substances: cocaine, methamphetamine and MDMA, which are much more difficult to produce.

It is important to note one useful physical property of methcathinones - the ease of obtaining crystals. Hydrochlorides are well crystallized, as well as hydrobromides.

I have been producing various methcathinones for 15 years, many of which I have biotested personally for research purposes. If anyone has questions about synthesis, the choice of substance, the availability of reagents, then I will gladly share my experience.
Please share easiest method of making mephedrone using HBr instead of bromine
 

HIGGS BOSSON

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Please share easiest method of making mephedrone using HBr instead of bromine
Soon we will publish a video with this synthesis. We've already shot a clip, the video is being edited.
 

Marvin "Popcorn" Sutton

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Please share easiest method of making mephedrone using HBr instead of bromine
 

vig212

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The class of methcathinones is the most promising direction in the modern drug market. The simplicity of synthesis opens up limitless possibilities for production in artisanal conditions, and the pharmacological activity of some variants, such as mephedrone, is simply amazing. All methcatinons are synthesized by one method. Choosing the necessary primary source - propiophenone, you can get substances of different properties.

Synthesis is easily scalable, unlike amphetamines. The availability and cheapness of the primary source makes the cost of the final product fantastically low. The average price of 4-methylpropiophenone in China is $50 per kilogram. With all the other costs for reagents, you can achieve a cost of $ 150-200 per kilogram of finished mephedrone in crystals. In the days of the legality of designer drugs, it was possible to produce a substance from the methcathinone class legal for one's country without changing the synthesis technology. Now it is possible only in Africa that loopholes in the laws remain, but in most civilized countries all metcathinons are banned.

But reagents for synthesis are legal, and even if some propiophenons are banned, you can always slightly modify the substance produced, for example: 4-MMC can be replaced with 3-MMC by replacing 4-methylpropiophenone to 3-methylpropiophenone. Or replacing 4-MMC with 4-FMC, replacing primary 4-methylpropiophenone to 4-fluoropropionphenone. In addition to changing the position of the benzene ring substituents, longer chains, such as butyrophenone or valerophenone, can be used. The latter has other properties, and is well suited for the synthesis of pyrrovalerones: a-PVP and MDPV.

If you have difficulty buying methylamine to synthesize mephedrone, then this problem can be circumvented by using legal ethylamine to produce 4-EMC, a substance with a very similar euphoric effect. In fact, from the class of methcathinones, it is possible to synthesize any substances in action, based on the availability of reagents and market needs: euphoretics and stimulants for every taste, from soft fluoromethcatinones to very hard a-PVP.

Such simplicity of synthesis and availability of reagents open up huge opportunities for capturing the market - competition with classic substances: cocaine, methamphetamine and MDMA, which are much more difficult to produce.

It is important to note one useful physical property of methcathinones - the ease of obtaining crystals. Hydrochlorides are well crystallized, as well as hydrobromides.

I have been producing various methcathinones for 15 years, many of which I have biotested personally for research purposes. If anyone has questions about synthesis, the choice of substance, the availability of reagents, then I will gladly share my experience.
Please help with detailed process for making mephedrone
 
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