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The formula and synthesis of methadone


New member
May 15, 2022
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The synthesis of methadone☝️ is a fairly straightforward process. All you need are some chemical reagents and minimal laboratory equipment. Here is one way to get methadone in your home laboratory.
So, to begin with we add 900 ml of ordinary water to a 3-liter container. We add to it 900 grams of sodium hydroxide and mix it. Leave the resulting solution to cool at room temperature. After pouring the solution into another container👝. Now, add the obtained solution to 1120 grams of 1-dimethylamino-2-chloropropane hydrochloride. Stir well. The resulting base (oily brown substance) is separated from the main mass with a separating funnel. Wash the base 1-2 times with salt water. The oil should be about 800 gm.:sneaky:

Now let's proceed with the main reaction. We take a 4-liter flask and add 400 gm of diphenylacetonitrile and sodium hydroxide solution, which we prepared above. After that, it is mandatory to add 25 ml of tetrabutylammonium. All of this begins to boil slowly, stirring occasionally. Then, gradually add 800 ml of the previously prepared base to this mixture. Within 2-3 hours, if everything was done correctly, the base will be completely consumed. The cooking temperature should remain between 50-60 degrees Celsius for 8-12 hours. As a result, you should get a thick mixture, of light beige color. We pour it into separate containers and freeze in the freezer. Next, the resulting mixture is crushed and washed with water. All this is better to do in a gas mask and gloves🧤, as some parts of the mixture can be extremely toxic. We take a mortar, add petroleum ether in it, put the pieces of the obtained nitrile in it and grind. You have to grind each particle of the substance thoroughly. You need to replace the ether in the mortar with a new one about 4-5 times. The obtained beige crystals are dried in the open air.
Now the second stage of synthesis. We dissolve 300 grams of nitrile crystals in 300 ml of xylene. Then to this solution we pour 780 ml of ethylmagnesium bromide in ether. The solution is boiled at 80°C for three hours. Then we carefully add 15% hydrochloric acid to the solution. Once the acid reaction is done, pour everything into beakers and send to the freezer for 10 hours. The obtained crystals should be recrystallized from methanol a couple more times and that's it, the synthesis is finished. The resulting substance is enough for one dose of 250 mg.