Tramadol (Ultram) synthesis

[IHeisenberg]

I’m having trouble with grignard
Now I practically react 2-dimethyl aminomethyl cyclohexanone with Grignard reagent and I see temperature rises with every drop of the free base but when I quench the reaction with ammonium chloride I see small temperature rises with only few drops .
After distillation of the solvent and adding acid ( hydrochloric acid ) the product didn’t crystallize.
Maybe some moisture get contacted with the reaction because the apparatus may not well sealed.
Can this moisture breakdown the reaction Before quenching.

 

[G.Patton]

I’m having trouble with grignard
Now I practically react 2-dimethyl aminomethyl cyclohexanone with Grignard reagent and I see temperature rises with every drop of the free base but when I quench the reaction with ammonium chloride I see small temperature rises with only few drops .
After distillation of the solvent and adding acid ( hydrochloric acid ) the product didn’t crystallize.
Maybe some moisture get contacted with the reaction because the apparatus may not well sealed.
Can this moisture breakdown the reaction Before quenching.

IHeisenbergWhy did you quenched the reaction with NH4Cl?

I quench the reaction with ammonium chloride I see small temperature rises with only few drops .

 

[IHeisenberg]

Remind

 

[G.Patton]

Remind

IHeisenbergPlease, don't spam like this. It's worth to write me in DM instead.