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William Dampier

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UR-144 cannabinoid synthesis is represented in this topic.

Laboratory requirements:
The working place (a tabletop for laboratory syntheses and manipulations) must be supplied with exhaust ventilation and fresh air inflow. laboratory have to be equipped with multi-tiered racks for product drying. They have to be also supplied with good air ventilation. It is also worth to take care about weighing and packaging place. The place should has enough space, be convenient and be located under exhaust ventilation (preferably). Laboratory floors are recommended to be covered with a polyethylene film during synthesis procedures by reason that cannabinoid dust abundance cannot be avoided. Subsequently, the laboratory space will be more convenient to clean up by collecting polyethylene film.
Racks

Reagents:
2. Sodium hydroxide (NaOH);
3. Tetra-n-butylammonium bromide (TBAB) CAS 1643-19-2;
4. 1-Bromopentane (1-BP) CAS 110-53-2;
5. Distilled water (H2O);

Equipment and glassware:
1. Laboratory scale (0.1-200 g is suitable);
2. Flat-bottom flasks 10 l;
3. Funnel for bulk materials (with wide bottom);
4. Scoops for flour;
5. Beakers 1-2 l;
6. Electric burner;
7. Overhead stirrer (optional);
8. Silicone baking molds;
9. Syringes;
10. Blender;
11. Large bowl or bucket;

Individual protection:
Mask

1. Long sleeve chemical coat;
2. Respirator mask (or respirator + goggles);
3. Latex gloves;
4. Fabric gloves or a piece of thick fabric;

Addition:
1. TMCP-indol 2000 g is weighted and put into 10 l flask through a funnel for bulk materials;
2. Sodium hydroxide (NaOH) 1300 g is weighted and put into same flask;
3. TBAB 800 g is also weighted and put into same 10 l flask;
4. 1-Bromopentane 1500 g is poured into the flask;
5. Fresh water 3000 ml is poured there (better to use distilled water);
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Reaction:

The reaction mixture is stirred after reagents addition until NaOH is dissolved completely and two layers are formed. You can use cotton gloves under latex one to avoid burns, which can happen because NaOH dissolving is conducted with heat releasing. Also, it is recommended to use retort clamp apparatus.
Ur144rea1

As soon as two layers are divided and the all sodium hydroxide are dissolved, the flask is put onto the heating plate and the heating is turned on to the maximum power. Top stirrer is installed and turned on. In case you don't have a top stirrer, you have to use heat resistant gloves to avoid burns. The reaction mixture have to be stirred well in order to mix layers (be homogenized).
Ur144rea2

Top stirrer have to work during whole reaction procedure. In case you don't have top stirrer, reaction flask is shakes vigorously during whole reaction procedure. The simmer of reaction mixture is supplied until the mixture is become milky and without separated layers (homogeneous). It takes 15-30 min usually.
Ur144rea3

Next, heating plate is removed and reaction mixture is left for layer separation. Top layer is needed. Product can crystalize directly in the reaction flask, which makes it difficult to extract. According this fact, you have to do separation procedure quickly.
Ur144rea4

Top layer is moved into a beaker or directly into silicone molds (do not forget about the temperature, use thick gloves or towels). Top layer (oil) can be collected by a syringe. When the layer is become very thin, mixture can be poured into a measuring cylinder for much convenient handling.
Ur144rea5

Silicone molds with an oil layer are left for 24 hours to solidification. Silicone molds are used for more convenient handling because oil in these molds are solidified and taken their form.
Ur144rea6

Crystallized product is taken out and crushed. Than, UR-144 is placed onto trays, dried in well ventilated dry warm room. Usually, it takes 2 days. Also, you can use vacuum desiccator to dry it much faster. The yield is 3000 g.
Ur144rea7


This reaction procedure can be used for other JWH row cannabinoids.
 
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HIGGS BOSSON

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Reagents used in video:
  • 1.50 g 2,2,2,3,3-Tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole; CAS 895152-66-6);
  • 2.32 g Sodium hydroxide (NaOH);
  • 3.10 g Tetra-n-butylammonium bromide (TBAB, CAS 1643-19-2);
  • 4.46 g 1-Bromopentane (amyl bromide; CAS 110-53-2);
  • Distilled water;

Equipment and glassware:
  • Flat bottom flask 2 L;
  • Retort stand and clamp for securing apparatus;
  • Magnetic stirrer with heating plate;
  • Reflux condenser;
  • Funnel;
  • Syringe or Pasteur pipette;
  • Beakers (600 mL x3, 100 mL x2);
  • Vacuum source;
  • Laboratory scale (0.1-200 g is suitable);
  • Measuring cylinder 250 mL;
  • Glass rod and spatula;
  • Separatory funnel 1 L (optional);
  • Buchner flask and funnel;
  • Filter paper;

Video Description:
0:05-1:12 - Alkali solution preparation;
1:13-1:42 - TMCP-indole addition into reaction mixture;
1:43-2:08 - TBAB addition into reaction mixture;
2:09-2:32 - 1-Bromopentane addition into reaction mixture (Rm);
2:33-3:50 - Rm is stirred and heated with reflux;
3:53-4:20 - Water is added at room temperature to clean the product from impurities;
4:20-5:10 - Top layer, which is contained UR-144, is decanted. Then, the bottom layer is extracted with benzene or ether to increase the yield. Solvent from this stage have to be distilled off for further product purification. Following purification steps can be skipped and top layer can be used for smoking mixtures producing in according with theory yield.
5:11-5:55 - Crystallization of dirty UR-144.
5:56-7:10 - UR-144 recrystallization from isopropyl alcohol (IPA) for product purification.
7:15-8:00 - Crystallized and cooled alcohol solution of UR-144 is filtred on Buchner funnel and flask. Filtered crystalline product is washed on Buchner funnel with a pure cold IPA. Keep in mind that product losses are possible in case of poor crystallization and insufficient cooling.

Same procedures are for following substances syntheses:
JWH-018 from 3-(1-Naphthoyl)indole and 1-Bromopentane,
AM-2201 from 3-(1-Naphthoyl)indole and 1-Bromo-5-fluoropentane,
JWH-122 from 4-Methyl-1-naphthyl-indole and 1-Bromopentane.
And many different synthetic cannabinoids. 1-Pentyl-1H-indole chemical structure is one of the main affect key factor on cannabinoid receptors (CB1 and CB2).
 
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Gus

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this video isnt working , is there another way i can watch it ?
nevermind, you just need to wait a long time to load ,
 

battman23

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Reagents used in video:
1.50 g 2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole),
2.32 g Sodium hydroxide (NaOH),
3.10 g Tetra-n-butylammonium bromide (TBAB),
4.46 g 1-Bromopentane (amyl bromide).

Video Description:

0:05-1:12 - preparation of alkalis solution.
1:13-1:42 - loading in RM of TMCP-indole.
1:43-2:08 - loading in RM TBAB.
2:09-2:32 - loading in RM 1-Bromopentane.
2:33-3:50 - stirring and heating with reflux RM.
3:53-4:20 - addition of water at room temperature to clean the product of impurities.
4:20-5:10 - decanting the desired, upper layer, which contains UR-144. To increase the yield at this stage, it is possible to extricate the remaining lower layer with benzene or ether. The solvent after extraction must be distilled for further cleaning of the product. If necessary, you can skip all the following cleaning steps and use the top layer with the extract in the solvent for the manufacture of smoking mixtures, based on the calculation of yields.
5:11-5:55 - crystallization of dirty UR-144.
5:56-7:10 - recrystallization of UR-144 from isopropyl alcohol for product purification.
7:15-8:00 - filtration of the product on the Büchner funnel, pre-crystallized and cooled alcohol solution. Washing with ice alcohol. Keep in mind that product losses are possible in case of poor crystallization and insufficient cooling.

Similarly, it is possible to synthesize:
JWH-018 from 3-(1-Naphthoyl)indole and 1-Bromopentane,
AM-2201 from 3-(1-Naphthoyl)indole and 1-Bromo-5-fluoropentane,
JWH-122 from 4-Methyl-1-naphthyl-indole and 1-Bromopentane.
And many other synthetic cannabinodes.
The key to acting on cannabinoid receptors (CB1 and CB2) is part of the chemical structure of 1-Pentyl-1H-indole.
hi do you have a reliable source for theses raw materials
 

HIGGS BOSSON

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hi do you have a reliable source for theses raw materials
Unfortunately, we have no suppliers. You need to look in China or India for the main precursor, the rest of the reagents are easy to find.
 
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battman23

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what is the main precursor i will have difficulty finding and what reagents are easy to find
 

HIGGS BOSSON

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what is the main precursor i will have difficulty finding and what reagents are easy to find
2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole) - main precursor, when ordering it, the supplier will understand for what purposes the substance will be used, although it is legal
Sodium hydroxide - Alkali, easy to reach
Tetra-n-butylammonium bromide - catalyst, not as simple as alkali, but there should be no problems with ordering in chemical stores, does not cause suspicion
1-Bromopentane - is a second precursor, but it is easy to obtain.
 

battman23

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2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole) - main precursor, when ordering it, the supplier will understand for what purposes the substance will be used, although it is legal
Sodium hydroxide - Alkali, easy to reach
Tetra-n-butylammonium bromide - catalyst, not as simple as alkali, but there should be no problems with ordering in chemical stores, does not cause suspicion
1-Bromopentane - is a second precursor, but it is easy to obtain.
thank you bro
 

sirmtr

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the most beautiful community so far here, I'm glad for what you built here, who is the owner I propose to make donations, I will be the first to donate, leave a bitcoin address something
 

Bobi

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It is possible to use something else instead 2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole)
 

HIGGS BOSSON

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It is possible to use something else instead 2,2,2,3,3-tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole)
You can first get a pentyl-indole, and then hang on it 2,2,2,3,3-tetramethylcyclopropyl chloride.
Or to obtain TMCP-indole by synthesis from indole and 2,2,2,3,3-tetramethylcyclopropyl chloride.
In any case, to obtain the ur-144, you need three main components. The synthesis TMCP-indole is quite complex, and it is as convenient as possible to buy it ready-made.
 

Bobi

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After I have done all the steps shown in the video what material do I get
 

Bobi

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Is the final material in the video an active cannabinoid and can be made from synthetic cannabis
 

Bobi

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I'm just talking about the video
 

HIGGS BOSSON

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After I have done all the steps shown in the video what material do I get
You will get UR-144, an active synthetic cannabinoid with a very high-quality psychoactive effect
 

MrSung

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Can i use 1-H-Benzolpyrol,Indole-Food grade Kosher(C8H7N)instead of TCMP as main precursor following the above procedure and then obtain the same result?
 
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