Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.

[ASheSChem]

Pyrrolidine is findable in Europe ?

 

[HerrHaber]

even though it is commercially available and without any reason for it being suspectable (at least not where I am at), surely somebody around here can provide it, moreover it can be obtained from the aminoacid proline by thermal decarboxylation (heating it in a high boiling point solvent but not higher than it actually boils so it does not evaporate out)

 

[William Dampier]

No. 0,9kg (~1L) of pyrrolidine for 1kg alpha-bromovalrophenone.

 

[FishAndChips]

You mean the porpotion is 1L of Pyrrolidine for 1kg
2-bromovalerophenone but how many Ethyl acetate do l need to make Alpha-PVP?

 

[trump69]

Can someone please answer he is question?

 

[Osmosis Vanderwaal]

2.64848L per kg based on mole density
Mole of 2-b-v=242 grams
Mole of e acetate= 98ml

 

[Osmosis Vanderwaal]

That related to the 4L to 1.5 kg in the list

 

[Marvin "Popcorn" Sutton]

100g bk,100ml pyrrolidine (~90g) ,400ml EtAc
these are the correct proportions for the AMINATION step
after completion of the reaction add 600ml of water to wash and separate the organic phase
acetone is added before acidification, after the organic layer has been separated from the aqueous layer.

 

[trump69]

What's bk?

 

[VamonosPest]

What could i replace pyrrolidine with?

 

[Hank Schrader]

Methylamine. You will get also good product.

 

[VamonosPest]

And how about the legality of pyrrolidine and 2-bromovalerophenone?
are these watched in europe can i order them safely?

 

[G.Patton]

Hi. They are legal in EU.

 

[VamonosPest]

Thank you for reply

 

[G.Patton]

You wrote quite obvious things. What is a main idea of your message?

 

[Caleb]

Actually the idea was to show (again) that people using substances are being treated llike criminals.
In some places they are even seen worse than child molesters and suicide bombers.
This speaks for itsel.

 

[madmoney69]

Have pyrrolidine 4kg left if smb need. Only europe

 

[Hank Schrader]

Different methods of crystallization and dyes.
The form can be in A-PVP in the flesh to the shape of a brick.
Crystallization on mixtures of alcohol. Crystallization in liquid nitrogen. Crystallization on water in vacuum chambers.

Dyes are used for food and in very small quantities, which allows you to use PVP in smoking ways.

Some consumers demand red, others claim that green is stronger!
Although we take a white product from one reactor.
This is very funny.

From a chemical point of view, of course, the white standard of quality.

 

[FishAndChips]

Hi! I cant find the proportion of how many 2-bromovalerophenone i need to use,someone can help me?

 

[G.Patton]

Hello, you have to use molar ratio. Count it as in the example, described in the topic. You can read about this method more in Moles, grams, litres and chemical calculations topic.

 

[FishAndChips]

I have 1L of 2-bromovalerophenone how much ethyl acetate and how much pyrroxilidine i need to put for amination?

 

[trump69]

Amination α-PVP synthesis from 2-Bromovalerophenone

I would like to know if this is correct since I started to buy 1kg of 2-bromovalerophenone then l skipped all the steps and l m not sure of the porpotion but if someone can helping? I can pay it

Ethyl acetate 400 mL

pyrrolidine 87g

2-bromovalerophenone 87g

Is that correct porpotion, guys?

 

[G.Patton]

Hello, yes. You can start from 2-bromovalerophenone for sure.

 

[VietNamese Bad Meth]

not stage 4

 

[pachemguy]

How much methylamine would one use for 1kg of bk ??

 

[OrgUnikum]

262 g is absolute minimum, realistically 280 g - 300 g.
Thats 700 g - 750 g of a 40% MeNH2 solution in water, look at the 4-MMC synth which uses EtOAc for the workup/crystallisation as it won't work as here described for the water.

 

[w2x3f5]

if use alkali, then half the amount of methylamine is needed in theory, then 1 mol of methylamine, 1 mol of bromovalerophenone and 1 mol of alkali. We also take into account that an aqueous solution of methylamine erodes during storage, a good excess of methylamine will additionally mix the reaction in the direction of the formation of aminoketone

 

[OrgUnikum]

Sure. I was going after the first post in the thread which does not mention alkali. The best alkali would be cesium carbonate, but potassium carbonate is known to work too, personally I would not use MeNH2 in water anyways, although a certain amount of water does not hurt, thats getting really a lot. I would use 1,2 equv. MeNH2.HCl and Triethylamine to free the methylamine from the salt and to scavenge the formed HBr.

I am also unsure how active the resulting compound is, I have the feeling the pyrovalerone might be superior. Any genuine knowledge regarding this question would be appreciated.

 

[pachemguy]

Copper carbonate is not a good catalyst for this reaction copper chromate or acetophenone dose a great job I also have found success with spearmint oil and turpentine

 

[pachemguy]

Wish I could get my hands on 55gal drum you ever wanna come up off some of that lmk lol