Amfetamino sintezė iš P2NP naudojant NaBH4/CuCl2 iš vieno puodo (1 kg skalė)

[William Dampier]

Reakcija su natrio borohidridu gali tapti nekontroliuojama, jei nekontroliuosite temperatūros. Be to, mažos dispersijos vario junginiai gali trukdyti gryninti galutinį produktą.

 

[Johnny Ringo]

Kann man die kupferverbindungen verhinden und ist das produkt(base) geeignet paste herzustellen wenn man es nicht mit aceton wäscht und nur schwefelsäure hinzu fügt?

 

[Johnny Ringo]

Und wie kann man es am besten beheizen, da die kontaktfläche bei rundkolben schlecht hitze absorbiert und es sehr lange dauert wenn man versucht den kolben direkt zu beheizen.

 

[Sasha89]

Ką naudojate išoriniam šildymui, kad 30 min. palaikytumėte 80 °C temperatūrą?

 

[GDC]

Metalinis šuns maisto šėrimo indelis su vandeniu.

 

[Johnny Ringo]

Bin auf das problem gestoßen,dass das wasser verdampft ist bevor es 80grad erreicht hat könnte ich es mit öl erhitzen?

 

[SelfExper1menter]

Sveiki visi. Bandžiau pagal šį receptą nedideliu mastu pasigaminti šiek tiek amfetamino, bet nepavyko. Viskas atrodė gerai, išdžiūvus mano produktas atrodė kaip balti milteliai su raudonumo atspalviu. Jei tai būtų amfetamino sulfatas (kurį bandžiau pagaminti), išeiga būtų 84 %. Problema ta, kad tai ne amfetaminas.

Fiziologinis poveikis
Išbandžiau 20-30 mg, stimuliacija neabejotinai buvo, bet taip pat sukėlė karščiavimą ir, matyt, imuniteto susilpnėjimą: abu kartus, kai vartojau kelias dienas iš eilės, susirgau kvėpavimo takų infekcijomis (pirmą kartą maniau, kad tai sutapimas). Kitas jį vartojęs asmuo nepatyrė jokio stimuliavimo nuo iki 90 mg, tik šiek tiek džiūvo burna. Nė vienas iš mūsų neturime jokios tolerancijos stimuliantams.

Cheminiai tyrimai
1 g miltelių visiškai ištirpsta 10 ml H2O.
Į mėgintuvėlį įpylus perteklinio NaOH tirpalo į išmatuotą miltelių masę, gavau maždaug teisingą laisvosios bazės, turinčios amoniako kvapą, tūrį. Atskyriau laisvosios bazės sluoksnį, išdžiovinau jį CaCl2 ir pabandžiau titruoti rūgštimi. Rezultate išmatavau, kad frebazės molinė masė yra maždaug 171 (o amfetamino - 135). Nors mano matavimai nebuvo labai tikslūs, skirtumas vis tiek yra per didelis, kad jį būtų galima paaiškinti vien matavimo paklaidomis.

Mano nukrypimai nuo procedūros
1) Pridėdamas P2NP supratau, kad tai užtruks kelias valandas, todėl tapau nekantrus ir panardinau reakcijos kolbą į kambario temperatūros vandens vonią. Po to P2NP galėjau pridėti beveik visą vienu metu, o mišinio temperatūra neviršijo 40-50 °C.
2) Vadovavausi vaizdo įrašu, todėl neišgarinau IPA ir tiesiai į IPA ir (arba) freebazės sluoksnį įpyliau konc. sieros rūgšties.
3) Šiuo metu neturėjau acetono, todėl prieš parūgštinimą jo nepridėjau, o filtruotą "amfetamino sulfato" pastą nuploviau IPA.
4) IPA yra mažiau laki nei acetonas, todėl savo nuosėdas turėjau kelioms valandoms įdėti į orkaitę, kad išdžiūtų iki pastovaus svorio. Temperatūra orkaitėje neviršijo 80 °C.

Taigi, pagrindinis klausimas, kur nutiko klaida? Nenustebčiau, jei išeiga būtų nedidelė arba produkto visai nebūtų, bet gauti gerą amino, kuris nėra amfetaminas, išeigą?!

 

[OneTensionSkyRed]

That's what I was thinking. This reaction produces N-OH-amphetamine instead of pure amine. People can clearly tell the difference between their physiological activity.

 

[pekonias]

I don't anderstand what is happening? I used 300g NaBH4 2.07 L IPA, 1.03 L dH2O, 173g P2Np 22g CuCl.2H2O and everything went well - reaction over and I add 0.4 L 25% NaOH sol. to get (pH 13.5) separate layers but... there's wery little separation. The aq. layer was only 0.3L so now I have 2.2 L organic layer, more than starting IPA + H2O (2.1 L). So does organic layer now contains NaOH? The pH after reaction was ~12 and there was no layer separation so I added the 0.4 L NaOH sol. What should I do now? Add more NaOH sol. and vacuum distill? Maybe acidify to pH <=3 and distill. Please advice guys.

 

[pekonias]

Obviously I can't count, actually got correct volume for the organic part and also extracted the sludge with 0.3L IPA. It's very confusing when told to add NaOH to pH 12 when it's already at that after reaction. Also aq. part seems to small but it's mostly in the black mud. Going to go ahead with water aspirator vacuum distilling off the IPA and hopefully not lose all product like last time. I think got too hot 80C with -28" Hg vacuum last time. Maybe report how it went tomorrow if has any luck.

 

[OneTensionSkyRed]

You need to add more NaOH in dry form or at least concentrated NaOH solution if you don't want to heat RM from dry NaOH to separate IPA layer. The densities are similar and that prevents IPA from salting out. Have you destroyed borate adducts afther the reaction?

 

[two777]

what is the optimal temperature for a-oil, before you start the extraction/ crystallization process using sulfuric acid? Usually im working with room temperature oil, and adding acid gradually, by not extending temperatures above 40c.

 

[GhostChemist]

this is right

 

[pekonias]

Follow up to my previous post, copule observations made during the process I think are important to share. This was really my very first success at this. From 173g P2NP I got ~130ml clear oil. What I wanna say is that now, compared to the previous experiment, was very different at the step when CuCl added. Previously added it dropwise and the temperature didn't increase at all, no storm in flask and only gave test subjects a runny nose. Now had twice as much and better quality P2NP. Also 10% of the NaBH4 was added later, after most P2NP had been added but it don't seem make no difference. So the CuCl was added added in 3 bursts of 10ml each and very violent reaction was observed (~1/4 CuCl soln. was left unadded). After each 10ml addition the reaction almost came out of the flask but not quite and the temperature increased dramatically. The Rm was 3.1 L in 5 L RBF. Temp reached 78C after third addition and the surface / foam level stayed really high for a minute and the reflux from the two ball condensers poured down IPA/H2O like hell. Unreal sight but it happened and I think the reflux prevented temp. going > 78C. So I much rather want the violent reaction then I know something is really cooking and reacting. The organic layer was condensed in -26.25" Hg vacuum BP 37-38C. Vacuum dist. stopped when 1.8 / 2.2 L liquid was removed (BP. was 41.8C at end). Then steam distilled. First 100ml of distillate thought to be water and almost thrown away! It's A-Oil! Thinking drying some of it by mixing 50ml Oil with 300ml? dry IPA and giving it 20g silica gel and let sit overnight. How much H2O should the vacuum distilled IPA contain? Would be nice to re-use it. I measured its density to be ~0.8g/ml which is that of IPA (0.786g/ml) within the measurement accuracy?

 

[OneTensionSkyRed]

DO NOT dry it with silica gel or molecular sieves. They are acidic and should not be used for drying amines.

 

[keras]

So to cook 1kg of amph would cost more than to make 1kg 3cmc?
Becausd borohydride I see costly in poland , also p2np add up. While 3cmc is one main precursor.
And how these guys sell amp paste for less than 1k per kg. Where profit comes from ?

 

[dobrytowar55]

So then i Ask for most beacuse i knows on netherland production cost is between 300-600euro. How ? I dont mnie but meaby someone tell me herę

 

[dobrytowar55]

Hi. Can someone tell me what the cost of ingredients and equipment for producing 1kg is? I would be grateful if someone could tell me if it is enough to scaling up everything to get a larger amout or does that cause any discrepancies? Also can someone tell me what is the CAS of this final product?

 

[GhostChemist]

Find it in our Comercial Section

 

[OneTensionSkyRed]

It would be really REALLY great if someone could run a TLC analysis of the products from this reaction. I've read that NaBH4/Cu reduction mainly produces N-hydroxylamines instead of amines for alpha-alkyl nitrostyrenes. Because of similar melting points for their salts and similar boiling points, the only way to separate and identify N-OH-amphetamine is by chromatography. The N-OH product is also active as a stimulant but it is different to amphetamine. I wonder if this is really true.

 

[GhostChemist]

what source reports this information?
all compounds tested with qualitative and quantitative analysis
N-OH group can be formed as an intermediate compound if the experiment is not carried out correctly

 

[OneTensionSkyRed]

Yes, I should have probably researched this a little more before posting here, apologies. The source for this comes from amateur chemists and there aren't any official publications to support this

 

[OrgUnikum]

No. N-Hydroxylamphetamine is not stable in ph >7 it would go instantly to the Oxime and then back to the carbonyl say P2P.

 

[rampage]

is Copper (II) Chloride Dihydrate ok to use or does it have to be Copper (II) Chloride?

 

[GhostChemist]

In this synth dihydrate is used

 

[gmanaus]

I used copper sulfate and dried it till gray and it worked just fine

 

[GhostChemist]

If it is really works, then this is a good experience