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How about final fractional destillation of the last filtrate? Any possibility to recover unreacted viable nitroethane? It's really precious these days ...
 
Hi. What's the CAS number of cyclohexamine? I need it because i can only find cyclohexylamine. Thanks.
 
perfect video

Please put the synthesis clip of 4-chloro-1-butanol, it is not available anywhere on the internet, thank you
 
More for curiosity, When looking a nitroaldol/Henry reaction i notice that the carbonyl gets reduced only once and stays, somehow with our reaction, the P2NP is made without there being a hydroxy group anywhere.... Is this because we used a mild base, cyclohexylamine/n-butylamine instead of NaOH? Does that somehow reduce it all the way?
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Also, can MeOH be used instead of GAA? I can get GAA, but methanol can be found at any gas station....
 
Still curious is sodium methoxide can be used as the base or if that's only with certain styrenes? I've been unable to find any mention of it. Also, many years ago I used Diphenylamime and got an amazing yield. Unfortunately I can't recall any of the conditions or the exact styrene that was being produced. I do remember being surprised be the outcome. Same with no mention of it anywhere..
 
After P2NP crystallized out you shall distill off 60% from the liquids left over, add 1 gr crystall P2NP into it, put in freezer and another 5-8% of P2NP will crystallize out from that (little darker, need to be re-crystallized 2x). P2NP shall always be washed with sodium bisulphite to rinse out contamination of benzaldehyde, the benzaldehyde interfere in whatever method you had in mind for your P2NP. A 6-8% solution sodium bisulphite in water wash out all benzaldehyde contaminatioon from the P2NP.

Running this reaction in an ultrasonic bath instead of reflux give better yield with less than half time work. 2.5 hrs US power at 40-45 KHz. Methylamine in dry MeOH instead of GGA + cyclohexylamine gives higher yield. Try it and you'll see guys.

My synthesis: 1M benzaldehyde, 1.1M nitroethan, 0.1M methylamine in 600 ml dry methanol. Let stand in darkness 2 wks and you hit minimum 75-79% yield, after 3 wks 83-87%. If you don't like waiting that long, run it in ultrasonic power 2.5 hrs and you'll have 7-10% less yield. Standing 3-4 wks in darkness give highest & cleanest yield every single time
 
I wanted to ask a question in this video in the description one reagent is quite tight as well as in the video it is not cyclohexamine to what they adhere to since the description is written either as in the video or you can make a video full video how to start synthesize p2np and then how to synthesize amphetamine thank you
 
Found this in Rhodium :
Written by Zorohustra


Chemicals​

  • 80 mL Toluene (ACS)
  • 40 mL Benzaldehyde (~99%)
  • 30 mL Nitroethane (>99%)
  • 10 mL n-Butylamine (p.a.)
Do we need to use toluene aswell ? can someone post measurments for small scale.. iam trying to get 10grams P2NP
 
هل من الممكن استبدال سيكلو هكسيل أمين واستخدام ميثيل أمين؟
 
Found this in Rhodium :
Written by Zorohustra


Chemicals​

  • 80 mL Toluene (ACS)
  • 40 mL Benzaldehyde (~99%)
  • 30 mL Nitroethane (>99%)
  • 10 mL n-Butylamine (p.a.)
Do we need to use toluene aswell ? can someone post measurments for small scale.. iam trying to get 10grams P2NP
No, follow this video tutorial. If you need measurements for 10g, calculate them in accordance with same molar ratio. There is tutorial How To.
 
More for curiosity, When looking a nitroaldol/Henry reaction i notice that the carbonyl gets reduced only once and stays, somehow with our reaction, the P2NP is made without there being a hydroxy group anywhere.... Is this because we used a mild base, cyclohexylamine/n-butylamine instead of NaOH? Does that somehow reduce it all the way?
There is no -OH group by reason that conjugate -NO2 group in the molecule of P2NP make the substance more stable.
Also, can MeOH be used instead of GAA? I can get GAA, but methanol can be found at any gas station....
I don't think so, GAA has more acidic proton (H+).
 
Genuine question, if SWIM replaces the cyclohexylamine with n-butylamine, should he use the same amount/ratio shown in the video? Also, many people use Ethanol or Methanol instead of GAA, so would that be viable?

I do not know if I can link videos but there is one on youtube with n-butylamine and Ethanol and it seems to work.
Thanks
 
Hello.
Is there anything else I can use instead of cyclohexane? Chatgpt said I can use diethyl ether. Do you think that's right?
 
After P2NP crystallized out you shall distill off 60% from the liquids left over, add 1 gr crystall P2NP into it, put in freezer and another 5-8% of P2NP will crystallize out from that (little darker, need to be re-crystallized 2x). P2NP shall always be washed with sodium bisulphite to rinse out contamination of benzaldehyde, the benzaldehyde interfere in whatever method you had in mind for your P2NP. A 6-8% solution sodium bisulphite in water wash out all benzaldehyde contaminatioon from the P2NP.

Running this reaction in an ultrasonic bath instead of reflux give better yield with less than half time work. 2.5 hrs US power at 40-45 KHz. Methylamine in dry MeOH instead of GGA + cyclohexylamine gives higher yield. Try it and you'll see guys.

My synthesis: 1M benzaldehyde, 1.1M nitroethan, 0.1M methylamine in 600 ml dry methanol. Let stand in darkness 2 wks and you hit minimum 75-79% yield, after 3 wks 83-87%. If you don't like waiting that longer , run it in ultrasonic power 2.5 hrs and you'll have 7-10% less yield. Standing 3-4 wks in darkness give highest & cleanest yield every single time
Could you write up a work up on your preparation of the methyllamine in MeOH? I’m assuming SWIY synthesized methlyamine hcl and then freebased it w KOH or NaOH? I think I read somewhere that KOH was more readily soluble in methanol.

Anyway thanks
 
After P2NP crystallized out you shall distill off 60% from the liquids left over, add 1 gr crystall P2NP into it, put in freezer and another 5-8% of P2NP will crystallize out from that (little darker, need to be re-crystallized 2x). P2NP shall always be washed with sodium bisulphite to rinse out contamination of benzaldehyde, the benzaldehyde interfere in whatever method you had in mind for your P2NP. A 6-8% solution sodium bisulphite in water wash out all benzaldehyde contaminatioon from the P2NP.

Running this reaction in an ultrasonic bath instead of reflux give better yield with less than half time work. 2.5 hrs US power at 40-45 KHz. Methylamine in dry MeOH instead of GGA + cyclohexylamine gives higher yield. Try it and you'll see guys.

My synthesis: 1M benzaldehyde, 1.1M nitroethan, 0.1M methylamine in 600 ml dry methanol. Let stand in darkness 2 wks and you hit minimum 75-79% yield, after 3 wks 83-87%. If you don't like waiting that long, run it in ultrasonic power 2.5 hrs and you'll have 7-10% less yield. Standing 3-4 wks in darkness give highest & cleanest yield every single time
So it’s capable of just reacting on its own? And methylamine is the catalyst that can work like n butylamine?
 

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Synthesis of Amphetamines (Phenylethylamines)
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