No, you have to make free base only.
Last edited:
Methamphetamine synthesis from P2P by NaBH4 reduction. Medium-Scale.
- Thread starter G.Patton
- Start date
Hello,
After many tests using Methylamine HCL based on this method I will share the best way that I found to obtain Methamphetamine freebase in big scale:
- Fill the reactor with the 14 L of Methanol
- With stirring dissolve the Methylamine HCL
- Put the reactor temp at 0C(not the mixture temp) and add the NaOH, the temp will increase
- Once the temp come back to 20C add the P2P, the temp will increase stir it during 45min-1 hour
- Add 252gr of anhydrous sodium sulfate
- When the mixture temp arrives to 8C start adding portionwise the NaBH4 not exceeding the 20C
- Once all the NaBH4 has been added let it mixing under 20C during aprox 2 hours until the mixture stops bubbling
- Add the water and continue mixing during 5 min
- Add the DCM and mix it during 10 min
- Stop stirring and let layers get separated
- Keep the bottom layer and discard the upper one( not profitable to extract this aqueous phase)
- Add 200gr of anhydrous sodium sulfate to the saved layer and mix it
- Filter it in Buchner Funnel
- Evaporate the DCM
- Clean and smelly Methamphetamine freebase obtained
;-)
After many tests using Methylamine HCL based on this method I will share the best way that I found to obtain Methamphetamine freebase in big scale:
- 966 gr P2P
- 14 liters Methanol
- 1183 gr Methylamine HCL
- 638gr NaOH
- 452 gr Anhydrous Sodium Sulfate
- 105 gr NaBH4
- 35 L distilled water
- 7 Liters DCM
- Fill the reactor with the 14 L of Methanol
- With stirring dissolve the Methylamine HCL
- Put the reactor temp at 0C(not the mixture temp) and add the NaOH, the temp will increase
- Once the temp come back to 20C add the P2P, the temp will increase stir it during 45min-1 hour
- Add 252gr of anhydrous sodium sulfate
- When the mixture temp arrives to 8C start adding portionwise the NaBH4 not exceeding the 20C
- Once all the NaBH4 has been added let it mixing under 20C during aprox 2 hours until the mixture stops bubbling
- Add the water and continue mixing during 5 min
- Add the DCM and mix it during 10 min
- Stop stirring and let layers get separated
- Keep the bottom layer and discard the upper one( not profitable to extract this aqueous phase)
- Add 200gr of anhydrous sodium sulfate to the saved layer and mix it
- Filter it in Buchner Funnel
- Evaporate the DCM
- Clean and smelly Methamphetamine freebase obtained
;-)
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- By hunter12
Do you vacuum distill your oil freebase before crystallisation?
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So you can do an external steam distillation I asked this question I wanted to ad d dry caustic then steam distil the frebaae
- By Tweaker
I tried this method and didn't have the expected results. I have completed a very similar reaction with pmk with fantastic results. So I'm very confused.
mixture of methanol, methylamine and NaOH caused an evolution of gas and a milky white solution. Temperature rose and came back down.
P2P was added. Solution remained milky white with a brown swirl of p2p going through it as it mixed.
NaBh4 was added slowly temperature never rose over 10c. Mixture began to bubble and continued doing so for an hour until it ceased.
After extraction with DCM and evaporation a yellow oil was left with properties similar to the original P2p that was added.
mixture of methanol, methylamine and NaOH caused an evolution of gas and a milky white solution. Temperature rose and came back down.
P2P was added. Solution remained milky white with a brown swirl of p2p going through it as it mixed.
NaBh4 was added slowly temperature never rose over 10c. Mixture began to bubble and continued doing so for an hour until it ceased.
After extraction with DCM and evaporation a yellow oil was left with properties similar to the original P2p that was added.
- By btcboss2022
How much water added in the last step?
If you followed all in the same way and didn't works could be any of the reagents used no other option because a lot of people and myself did it hundreds of times.
If you followed all in the same way and didn't works could be any of the reagents used no other option because a lot of people and myself did it hundreds of times.
