1-Phenyl-2-nitropropene (P2NP) Video Synthesis From Benzaldehyde and Nitroethane. Henry Reaction.

[HIGGS BOSSON]

Problems with nitroethane in Europe began back in 2007, then gradually all countries put restrictions on this valuable reagent. And now there are two ways: to look for suppliers in countries where there is weak legislation with a developed chemical industry, for example, Bangladesh, or to synthesize independently, the methodology for this we have proposed.

 

[Alojz]

Wodurch kann man Nitroethan ersetzen oder selbst synthetisieren?

 

[Kvadprime]

You can find methods of syntes nitroethane in another thread

 

[Kvadprime]

I have aniline as a base - what yeilds can it give?

 

[G.Patton]

Try and figure out. Share us your research data. In theory, it's quite weak base and it would be not enough to eliminate -OH group.

 

[Kvadprime]

ok, I'll definitely write how everything went... I'm still waiting for my new labware to arrive

Thx

 

[rampage]

has anyone done the microwave version of this synthesis, curious as to the outcome?

 

[William D.]

This is an effective method. I irradiate at maximum power in short time intervals so that the mixture does not have time to boil.

 

[rampage]

that is the key, stopping the irradiation just prior or as soon as you see 1 tiny bubble rise up, did this method with very good success, simple but very effective. would be very interested if there's other synths that can be done using the microwave??

 

[William D.]

Stop when strong boiling begins. Yes, this is visible by bubbles. There are many different syntheses with MW, there are also on the forum. I think that ultrasound for p2np should also work well.

 

[Chemdog010297]

Can u use trimethoxybenzaldehyde, dimethoxybenzaldehyde, or fluorobenzaldehyde for this synth ?

 

[homestead]

Why is cyclohexylamine in the video but not in the ingredient list?

 

[GhostChemist]

n-Butylamine is in the starting reagents
Cyclohexylamine is variant of catalyst

 

[homestead]

Okay so cyclohexylamine is definitely required?

 

[Idontcarethatmuch]

No it isn't. "variant" and "catalyst" should say everything. Shouldnt it?

 

[Chemtrail]

Disagree.

There are a variety (cyclohexylamine, butylamine, ammonium acetate, methylamine, etc. ) of such catalysts

With benzaldehyde and nitroethane ---> P2NP

 

[Idontcarethatmuch]

So you don't disagree with me?

 

[GhostChemist]

n-Butylamine or Cyclohexylamine or another catalyst

 

[GANG64]

I have everything, nitroethane, benzaldehyde, N-butalamine, GAA, who wana halp me for synthesis P2NP?

 

[GhostChemist]

Method of synthesis in this post and videotutorial can help you

 

[Chemdog010297]

If you have no ability to freeze precipitate the p2np, can u separate the alcohol layer and evaporate solvent or acid extract ?

 

[GhostChemist]

Evaporation is bad idea
Better is adding some portions of water

 

[Chemdog010297]

Why so ? Evaporation or acid precipitation could make this process 12 hours shorter, cost a little more, but faster. It is doable correct ? Evan to p2np oil or acidify to salt form ? Idk chemistry in that much detail, but I would assume it is somehow doable