GHB (Gamma-Hydroxybutyrate) Synthesis FAQ

[TheWaterman]

Hi I have a question on Sand Mayer process. Will I be done with the process leaving me with GBL only if I stop after Step 4 in the extraction part as it seems like everything after makes it into GHB?

 

[G.Patton]

Hi, If I understand you correctly, you want to get GBL by Sandmeyer Reaction. Yes, you can get it at 4th step.

 

[Jeffrey B.]

cool, I found GABA in the form of gelatin capsules with just microcelulose as a filler, aswell as 50g bags of questionable purity for ~$10 a pop, sooooooo the pills are cheaper AND purer. I also can buy NaNO2 as some sort of gardening product from a chemical supplier for like $8 a kilo lol. I'm suprised no one here (Poland) makes GHB, its so easy but I've never seen it on the market. I will update whenever I have effects and/or questions

Actually, its still kinda unclear if im supposed to do both distillation AND extraction with DCM, how do i make sure im distilling GBL? isn't the RM full of water? GBL's BP is 204,6 °C, so do I just boil the RM until vapor temp. reaches 204,6 °C and collect from there?

Thanks in advance

 

[G.Patton]

DCM bp is 39.6*C
GBL bp is 204*C
There is clearly written that you have to distill off water at first. Read several times. I write the same as written in the topic.

 

[JustAnother0rganic]

hi,
i just followed the recipe, nothing burnt or too small flask , p
The liquid was crystal clear (except when adding the gbl, for 10mn) but the ph stay high. i ve added a lot of extra gbl i think but still green paper....>8
What can i do to lower the ph please ?
i didnt use a real liquid circuit reflux, but a long 30cm chemineee ended with a vigreux. you think a lot of H2O has gone ? it didnt look like it was fuming... slow boil.

 

[JustAnother0rganic]

it was distilled H2O,,
and was using a water bath to anticipate bs///

 

[G.Patton]

Hi, there is answer in the text:

It's hard to answer to such question. Too small input data.