JWH-018 synthesis. Small scale.

[G.Patton]

dear experts,
i was a while not active, because in my situation and location something changed.
I am now located in latin america (el salvador). And i never thought that it is in any country such difficult to get parcels delivered from abroad. I want to know, if anyone here of the experts and purchase helpers maybe has experience how it works here and hope maybe someone can help me how to get safe the integridents for a small scale, beginner friendly, cannabinoid synthesis.
regards

abbadonProbably, it would be much easy to move in Mexico and do your business there.

 

[abbadon]

out of researches, i know now here it is like this: when recieve a package from abroad, it must have an invoice in spanish, and every post office has an own customs department inside. Packages arrive not at your house they arrive at the post office. you have to be registered there, with phone number and they message you if something arrives. then you have to go there and open it with them together. It was even not easy to find such information.

 

[abbadon]

is it in mexico easy to get the required stuff imported? or maybe in guatemala if someone knows?

 

[abbadon]

Probably, it would be much easy to move in Mexico and do your business there.

G.Patton
i will follow the advice with mexico

 

[abbadon]

any recommended sources?

here is sheet with CAS. For some stuff you will need to bypass law (?) for instance pure ethanol its illegal in europe for domestic but just use cheep vodka and distilate it
for some reagent you will need to prove you own a company of some sort.

XenocodeRCE

 

[hofmaN.]

Inhave this , can i use in smal scale ? I have raw materials like for 50g

 

[Paparazzi]

Reaction scheme:

View attachment 1666 ​

Reagents:

• Indole (cas 120-72-9) 0.117 g;
• Aluminum oxide (Al2O3) 1 g;
• 1-Naphthoyl chloride (cas 879-18-5) 0.286 g;
• Sodium carbonate (Na2CO3) 0.16 g;
• 1-Bromopentane (cas 110-53-2) 0.18 g;
• Ethanol (EtOH) 60 ml;
• Distilled water;

Equipment and glassware:

• Microwave vial 5 ml;
• Microwave oven;
• Beakers 10 mL x2;
• Glass rod and spatula;
• Heating plate;
• Freezer;
• Vacuum source (optional);
• Schott filter and Buchner flask (optional);

Synthesis:

1. Indole 0.117 g is mixed with aluminum oxide (Al2O3) 1 g and mixed together until a homogeneous powder is formed.
2. 1-Naphthoyl chloride 0.286 g is added to the mixture and stirred to evenly mixed solution.
3. The final mixture is irradiated at 100 °С (400 W) for 8 minutes in a sealed 5 ml microwave vial.
4. The vial is cooled to a room temperature. Sodium carbonate (Na2CO3) 0.16 g as a finely ground powder and 1-bromo-pentane 0.18 g are added into the vial and then stirred to evenly mixed solution.
5. The resulting mixture is irradiated again in the microwave reactor (vial) at 100 °C (400W) for 4 minutes.
6. Then, ethanol (EtOH) 60 ml is added to the reaction mixture and refluxed for 20 minutes.
7. Aluminum oxide (Al2O3) is filtered and washed with distilled water 15 ml twice, and dried for next batch.
8. Ethanol solution (EtOH) with JWH-018 is treated with water 10 ml, placed in a freezer and crystalline JWH-018 is formed. Product is filtered on a Schott funnel and Buchner flask.

JWH-018 can be used as liquid. ​

William DampierCan we use distillation and put hot al2o3 in the way of the solution instead of refluxing?

 

[Paparazzi]

For all you guys... I've been trying this synthesis for 2 weeks now and nothing.... If there's anyone who's make it please I'm trying to get some help

 

[G.Patton]

Inhave this , can i use in smal scale ? I have raw materials like for 50g

hofmaN.There is manual, what exactly don't you understand?

Can we use distillation and put hot al2o3 in the way of the solution instead of refluxing?

I don't understand your question. There is two different steps: step 1 with Al2O3 and step 6 with reflux. You have to just repeat manual.

For all you guys... I've been trying this synthesis for 2 weeks now and nothing.... If there's anyone who's make it please I'm trying to get some help

What did you do exactly? Can you explain your procedure step-by-step?

 

[D4ftmonk]

In step 4, are the sodium and bromopentane mixed in first, or are they mixed into the mixture one by one?

And the step 7, what does it mean that the aluminum oxide is filtered first? Is aluminum mixed into mixtured first or what?

And also during the reflux process, what temperature should we use?

Please explain in more detail step 8.
Help.

 

[G.Patton]

In step 4, are the sodium and bromopentane mixed in first, or are they mixed into the mixture one by one?

D4ftmonkThe sequence is described in step 4. Do it one by one.

And the step 7, what does it mean that the aluminum oxide is filtered first? Is aluminum mixed into mixtured first or what?

What don't you understand? Read about gravity filtration here.

Please explain in more detail step 8.

Add 10 ml of water to the reaction vial, place reaction mixture into a freezer and crystalline JWH-018 is formed. Product is filtered on a Schott funnel and Buchner flask.
Suction (vacuum) filtration

You have to click links and read by yourself. Lab FAQ section consist of wide detailed explanations for all necessary procedures.

 

[D4ftmonk]

Okey, thanks sir. But, what about the temperature when the reflux proses?

 

[Eskobar]

Hi. say when the reaction in the microwave emits yellow smoke. this is normal?

 

[G.Patton]

Okey, thanks sir. But, what about the temperature when the reflux proses?

D4ftmonkTemperature of reflux means temperature when the solution is boiled. You can check solvent boiling point. Do you understand?

 

[G.Patton]

Hi. say when the reaction in the microwave emits yellow smoke. this is normal?

EskobarA little or a lot?

 

[Eskobar]

A little or a lot?

G.Pattona lot of. and the material is black

 

[G.Patton]

a lot of. and the material is black

EskobarProbably, you've burned your synthesis

 

[Eskobar]

tell me please. if you increase the dosage of ingredients 10 times. ethanol also ten times?

 

[Eskobar]

Probably, you've burned your synthesis

G.PattonI think so too. I will stay more

 

[G.Patton]

tell me please. if you increase the dosage of ingredients 10 times. ethanol also ten times?

EskobarX5 would be enough