G.Patton

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EjvKbG0PzF

Introduction

BB Forum team happy to post plain JWH-018 synthesis, which is not require rare or elaborated equipment and reagents. There is a step-by-step video guide and clearly written explanation of each step about JWH-018 cannabinoid obtaining with quite height yield. The synthesis can be repeated even by chemistry beginners.

Equipment and glassware:

  • 2 L and 1 L Flat bottom flasks;
  • Ice water bath (ice water or chilled brine);
  • Hot water bath;
  • Beakers 500 mL x3; 1 L x2; 3 L x1; 5 L x1;
  • Funnel;
  • Glass rod;
  • Buchner flask (~5 L) and funnel;
  • Vacuum pump;
  • Magnetic stirrer with heating plate;
  • Pyrex dishes x2;
  • Reflux condencer;
  • Syringe 20 cm3;
  • Plastic spoon;
Reagents:
  • Indole 100 g;
  • Dichloromethane (DCM) 500 mL;
  • Aluminum chloride 114 g;
  • 1-Naphthoyl chloride 163 g;
  • Distilled water 3.2 L;
  • Isopropyl alcohol 10 L or ethanol;
  • Sodium hydroxide 50 g;
  • TBAB (tetrabutylammonium bromide) 25 g;
  • 1-Bromopentane 75 g;
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Difficulty rating: 2/10

Stage 1. 3-(1-Naphthoyl)indole Synthesis From Indole

1. Indole 100 g is poured into a 2 L flask.
2. Dichloromethane (DCM) 300 mL is added into the same flask.
3. A reaction mixture is stirred until a complete indole dissolution.
4. The mixture is cooled down in an ice bath (ice water or chilled brine) to 0-10 °C.
5. Aluminum chloride 114 g is gradually added while stirring.
6. The mixture is stirred until a complete aluminum chloride dissolution.
7. 1-Naphthoyl chloride 163 g is weighted in a beaker and DCM 200 mL is added there.
Note: 1-Naphthoyl chloride has a solid state, but it can be easily melted if you place its container in a hot water bath.
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8. 1-Naphthoyl chloride DCM solution is gradually added from the beaker into the flask. Reaction mixture temperature is maintained at 0-10 °C.
9. After this addition, the flask is left with a constant stirring overnight (or for a shorter time until crystallization is finished).
10. After a while, a solid precipitate is crystallized in the mixture. Crystals has to be crushed by glass rod.
11. Pour the reaction mixture in small portions with a constant stirring into a vessel with 3 L of cold water. Raw 3-(1-naphthoyl)indole is precipitated and settled at the vessel bottom.
12. A 3-(1-naphthoyl)indole precipitate is separated from the water.
Note: You can dry and use raw 3-(1-naphthoyl)indole in this form, but it’s recommended to carry out an additional purification by recrystallization.


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Raw 3-(1-Naphthoyl)indole

Stage 2 (Optional). 3-(1-Naphthoyl)indole Recrystallization

13. Raw 3-(1-naphthoyl)indole has to be diluted in 10 L of IPA (or ethanol).
14. The mixture is stirred well and poured into a large beaker in order to simplify its loading to a 10 L flask.
15. After a making 3-(1-naphthoyl)indole solution more liquid, the mixture is poured into a 10 L flask and ethanol is added to fill the total 10 L flask volume.
16. The mixture is heated until a complete 3-(1-naphthoyl)indole dissolution.
17. Then, the mixture is cooled down, then the flask is placed in a freezer for two days until the end of precipitation.
18. Recrystallized product is filtered as the precipitate and dried up to a constant weight is achieved. After a drying, pure 3-(1-naphthoyl)indole 160 g is obtained.


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Recrystallized 3-(1-Naphthoyl)indole

Stage 3. JWH-018 Synthesis

19. Previously purified 3-(1-naphthoyl)indole 100 g is poured into a flask.
20. Sodium hydroxide 50 g is added.
21. Next, TBAB (tetrabutylammonium bromide) 25 g is added.
22. Water 200 ml is poured into the flask.
23. 1-Bromopentane 75 g is added.
24. A stirrer is turned on.
25. The reaction mixture in the flask is self-heated. An external heating is turned on until the mixture starts to boil. The boiling point is maintained for 15-30 min, depending on a boiling intensity.
26. A 1-bromopentane excess will be evaporated into an atmosphere (use proper ventilation). Reflux condencer is installed.
27. After a while, the mixture is poured into a beaker. The mixture is left for a layers separation.
28. The desired top layer is collected. The collected top layer is transferred into a separate vessel.
29. The oil is cooled down to room temperature (this procedure also helps to evaporate a 1-bromopentane excess if it is still there).

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The JWH-018 yield is ~125 g in the form of oil from 3-(1-naphthoyl)indole 100 g. Thus, ~200 g (69% from indole) of JWH-018 is obtained from 100g of indole.
 

Minicartel

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1. What is replacement for TBAB ?

2. In stage 3 can i added DMSO ?

3. maybe it is very difficult to get naphthoyl chloride, here I have benzoylindole, can benzoylindole be improved in reactive quality by adding other ingredients?
 

G.Patton

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1. What is replacement for TBAB ?

2. In stage 3 can i added DMSO ?

3. maybe it is very difficult to get naphthoyl chloride, here I have benzoylindole, can benzoylindole be improved in reactive quality by adding other ingredients?
Minicartel1. Tetrabutylammonium chloride
2. For a what reason?
3. I don't know how can I answer for this question, what do you mean "improved in reactive quality"? You need exactly reagents as in the tutorial. You can't turn benzoylindole into naphtoyl chloride. If you can't, make another cannabinoid
 

Minicartel

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1. other reagents besides TBAB and TBAC
2. Using dmso for solvent
3. I mean, how to increase benzoylindole to be stronger and longer effect, because I can't get naphtoyl chloride in my country, making other cannabinoids requires other reagents and pathways too, the problem is not all reagents are legally available in my country
 

Kjoodyy

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What is the alternative of naphthoyl chloride ?
 

handle

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Only one problem, will first need to produce the follow products from scratch!
Could you please send me the quick guide to synthesis the following;
Indole 100 g;
1-Naphthoyl chloride 163 g;
TBAB (tetrabutylammonium bromide) 25 g;
1-Bromopentane 75 g;

Should be Easy! 2/10 Difficult. Pffff


Easier to make this one. 1/10 Difficulty

5t0VyjwFHb
 

hydroman1212

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I have a question Stage 3. JWH-018 Synthesis?

At what temperature external heating is doneor what boiling point we have to maintained?
The reaction mixture in the flask is self-heated. An external heating is turned on until the mixture starts to boil. The boiling point is maintained for 15-30 min, depending on a boiling intensity.
 

mithyl2

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what solvent can i use instead of Dichloromethane? because Dichloromethane is hard to get where i am.
 

jhgg

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JWH-018 E-cigarettes can't be dissolved. How can I dissolve them in e-cigarettes?
 

joejoe354354

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100 g 3-(1-萘甲醯基)吲哚製得的 JWH-018 產量約為 125 g,呈油狀。因此,從 100 克吲哚中獲得約 200 克(69% 來自吲哚)的 JWH-018。
G.PattonAfter I got the oily product,Do I still need crystallization here? Or can it be used directly?
 

99%

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Hello everyone. Does anyone knows indole_s cas number?
Thank you!
 

99%

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Also needed supplier in Europe of this goods:
  • 1-Naphthoyl chloride
  • TBAB (tetrabutylammonium bromide)
  • 1-Bromopentane
Thank you!
 

belnkoks

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hello where to get Aluminium chloride ?​

 

Alex7920

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The naphthoyl chloride that I want to use in the synthesis of jwh-018 is in liquid form. Should I combine it with dichloromethane and then add to the solution? Can I add it directly to the mix?
 

a114488

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It's been a long time. Here's finally a video to watch! That's great,
So, you end up with oil? Instead of crystals?:):):):):):)
 

mekarjaya

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1 naftoil cloride Mine is liquid, is it the same as powder?
 

854513694

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Does this recipe allow all chemicals to be reduced to ½ in equal proportions? Will halving all reagents affect the results?
 
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