JWH-018 Synthesis Video

Hello Breaking Bad!
We present to your attention the long-awaited material on the synthesis of the most famous and best synthetic cannabinoid!
The synthesis is very simple from completely legal reagents.
It is also worth noting that you can work in several directions:
- synthesis and sale of semi-finished product (3-(1-Naphthoyl)indole)
- synthesis and sale of JWH-018
- production of smoking blends

In the near future, a video clip will be released on the production of synthetic hashish based on JWH-018, obtained during this work.

Hi, can it be turned into salt form?

Joker_333 said:

Hi, can it be turned into salt form?

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It isn't possible to turn a compound without acidic proton into the salt form.

G.Patton said:

It isn't possible to turn a compound without acidic proton into the salt form.

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Indole nitrogen can not accept proton?

Joker_333 said:

Indole nitrogen can not accept proton?

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It has no proton in JWH-018 molecule

G.Patton said:

It has no proton in JWH-018 molecule

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i now. I meant that the indole nitrogen reacts with the acidic proton. like hcl and...

Joker_333 said:

i now. I meant that the indole nitrogen reacts with the acidic proton. like hcl and...

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Oh, right. I have confused myself, sorry. Sounds correct but I never heard about salt form. Probably steric hurdles prevent this formation. Cl atom is quite large.

HIGGS BOSSON said:

Hello Breaking Bad!
We present to your attention the long-awaited material on the synthesis of the most famous and best synthetic cannabinoid!
The synthesis is very simple from completely legal reagents.
It is also worth noting that you can work in several directions:
- synthesis and sale of semi-finished product (3-(1-Naphthoyl)indole)
- synthesis and sale of JWH-018
- production of smoking blends

In the near future, a video clip will be released on the production of synthetic hashish based on JWH-018, obtained during this work.

Click to expand...

We hope to see a video of cannabis manufacturing soon. I truly thank you for your efforts

G.Patton said:

Oh, right. I have confused myself, sorry. Sounds correct but I never heard about salt form. Probably steric hurdles prevent this formation. Cl atom is quite large.

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It is an interesting topic. If you are a manufacturer, I suggest you do this test and make its salt.

It was a good video.

Well done

Hello,
I have a question regarding this synthesis. Why is N1 alkylation of indole performed as a last step. Can we acylate N-alkyl indole in the same C3 manner with specificity?
Thank you,
WoodChipperr.

would this be an option if you have low quality plant material but wish to make it more profitable? or is it very must distinguishable from a cannabis high?

Hi , thank you for the video , just a question what is the HPLC purity % ? (on the video above) ,what do you guys think about this patent purification/recristalization method ?: ! CN102838525A !
1-pentyl-3-(1 naphthoyl) indole bullion
drop into above-mentioned thick wet article in the 120ml methyl alcohol, and temperature rising reflux 1h is cooled to 15 ± 1 ℃, and filtration is watered with cold methanol and to be washed, drain refining wet article 56g; To make with extra care wet article and drop into vacuum rotary furnace drying bipyramid, be evacuated to-0.09Mpa, the logical circulating hot water oven dry of chuck; Water temperature is controlled at 55～60 ℃ of oven dry 7.5h, after offgas duct turns cold, is cooled to 25 ℃ of dischargings; Get 1-pentyl-3-(1 naphthoyl) indole product 51.5g; Yield 94.0%, purity (HPLC): 99.0%, M.P:66.5～67.4 ℃.

bbastardqua said:

would this be an option if you have low quality plant material but wish to make it more profitable? or is it very must distinguishable from a cannabis high?

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Hello,
are you referring to combining a low quality canabis plant with JWH-018 and selling it for more and if the high can be distinguishable ?

Well yes, I realize it isn't ethical, and I'm not exactly he'll set on doing it but it's just a hypothetical question. I don't see the harm. In asking tho I understand you don't want to be accosciated with emergency room trips if someone does this. Actually I'm interested in both and if the high is the same would it be detectable in thc urine test?

Possible to explode during the synthesis ?

bbastardqua said:

Well yes, I realize it isn't ethical, and I'm not exactly he'll set on doing it but it's just a hypothetical question. I don't see the harm. In asking tho I understand you don't want to be accosciated with emergency room trips if someone does this. Actually I'm interested in both and if the high is the same would it be detectable in thc urine test?

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The high is slightly different although depends on the quantity. Synthetic cannabinoids are way more potent then the plant. I'm pretty sure that yes synthetic cannabinoids are detectable in THC tests because synthetic cannabinoids trigger THC receptors in the brain with release the same metabolites as canabis although this is not applicable by all synthetic cannabinoids. My personal opinion is that drugs should not be associated with money and they should be widely available, so as in for the potential profits out of selling low quality weed laced with synthetic cannabinoids (although unethical) I really don't know.
-WC

WoodChipperr said:

I have a question regarding this synthesis. Why is N1 alkylation of indole performed as a last step. Can we acylate N-alkyl indole in the same C3 manner with specificity?

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Sorry, can you formulate your question clearly. About what specificity are you talking about?

Thanks

what can the DCM be substituted with?

Hi, I don't have access to indole and naphthoyl, their cost is more expensive than hashish itself. Can you post a video of their synthesis?

None said:

Hi, I don't have access to indole and naphthoyl, their cost is more expensive than hashish itself. Can you post a video of their synthesis?

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you should be able to get them for cheap from China

how can the jwh-018 oil be turned into powder?

A really nice practicable example for the Friedel Crafts Acylation