Methamphetamine synthesis from P2P by NaBH4 reduction. Medium-Scale.

[btcboss2022]

Hello,

After many tests using Methylamine HCL based on this method I will share the best way that I found to obtain Methamphetamine freebase in big scale:

• 966 gr P2P​
• 14 liters Methanol
• 1183 gr Methylamine HCL​
• 638gr NaOH​
• 452 gr Anhydrous Sodium Sulfate​
• 105 gr NaBH4​
• 35 L distilled water​
• 7 Liters DCM​

- Fill the reactor with the 14 L of Methanol
- With stirring dissolve the Methylamine HCL
- Put the reactor temp at 0C(not the mixture temp) and add the NaOH, the temp will increase
- Once the temp come back to 20C add the P2P, the temp will increase stir it during 45min-1 hour
- Add 252gr of anhydrous sodium sulfate
- When the mixture temp arrives to 8C start adding portionwise the NaBH4 not exceeding the 20C
- Once all the NaBH4 has been added let it mixing under 20C during aprox 2 hours until the mixture stops bubbling
- Add the water and continue mixing during 5 min
- Add the DCM and mix it during 10 min
- Stop stirring and let layers get separated
- Keep the bottom layer and discard the upper one( not profitable to extract this aqueous phase)
- Add 200gr of anhydrous sodium sulfate to the saved layer and mix it
- Filter it in Buchner Funnel
- Evaporate the DCM
- Clean and smelly Methamphetamine freebase obtained

;-)

 

[Su sho p]

Excuse me! After dissolving methylamine hydrochloride in methanol, the next step is to add sodium hydroxide at an ice bath temperature of 0 degrees, right？

 

[Sarah97]

Am I missing something, can you not simply steam distill the meth freebase directly from the reaction mixture once complete?
Or is there just too much water to freebase ratio for that not to work?

 

[GhostChemist]

steam distillation can not be applied for this RM

 

[nap]

While introducing hydrogen chloride gas from an HCl generator, I am encountering leakage and pipe ruptures. Could anyone recommend a suitable type of piping material or fittings for this application?

 

[G.Patton]

Hi. Borosilicate glassware and PTFE also good. Silicone hoses also suitable.

 

[nap]

Thanks for your reply. Please tell me the name of exact equipment. (Tube or etc).

 

[G.Patton]

How to Make HCl Gas - Safrole

How to make HCl gas (dry hydrogen chloride gas) at laboratory safe conditions will be also discovered in this article.

safrole.com

 

[Su sho p]

Teacher! Does setting the reactor temperature to 0 degrees mean adding sodium hydroxide after the ice bath temperature is set to 0 degrees?

 

[unclefesteraddams1]

Thanks