N-Ethylpentedrone Synthesis

[lapgan1]

Isn't it necessary to add solvent before adding ethylamine?

 

[G.Patton]

no

 

[61-50-7]

Is it necessary to stir that long ? Can't we just heat gently (~50/60°C) with a good stirring for just a few hours like for α-pvp (if the reaction takes place in ethyl acetate) ?

 

[G.Patton]

You can try and let us know. We haven't carried out an experiment.

 

[61-50-7]

Yield was 40% (by mass, from a-bromovalerophenone) but reagents hasn't been tested before and possible mistakes during the reaction. I'll try again soon and write a more detailled review

 

[61-50-7]

@G.Patton Do you know any simple method/company to test a-bvp quality ?

 

[G.Patton]

How much in grams or % in moles? Looking forward your report!

 

[G.Patton]

It ups to your location.

 

[61-50-7]

We works in europe but I wondered if companies could legally do that as it can be considered as "help" for the drug synthesis

 

[61-50-7]

~20L of a-bvp (=25/26kg) and gave 10kg after recrystallisation but I fear the bromo has been diluted or is just not pure enough bc it gave poor yield on simple alpha pvp synthesis too.
I believe we can achieve 70% (maybe we could heat gently).

Can we follow this reaction by pH ? Conductimetry ?

 

[G.Patton]

There are some laboratories, which carry out anonymous analyses of drugs. I assume that precursors also can be aniseed. @Chem-Safe is represented on BB Forum

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/b/EnergyControl/

 

[G.Patton]

What do u mean "follow this erection"? You can check its completeness by TLC.

10kg is 34.4% yield in moles from 26.2 kg (20 L). It's too small for this synthesis. Common yield is 70-85%.

 

[NEPking]

If anyone succeded, write me. I have breaking bad job opportunity

 

[61-50-7]

Currently working on that, I'll let you know

 

[Czekamnalepszedni]

Hi.
1-phenyl-2-bromopentan-1-one after bromination reaction is 2-bromovalerophenone CAS: 49851-31-2?
I already have 2BV ready, in the description it is written that you do not need to use a solvent during amination.
I pour 2BV, add ethylamine, separate the phases, acidify, filter and that's it? Can I use:
1) 2-bromovalerophenone
2) ethyl acetate
3) ethylamine
4) distilled water to separate the phases
5) acetone
6) acidification
7) filtration

 

[61-50-7]

yes, I got a poor yield using this solvent but I believe it's due to a bad quality 2BV more than a protocol issue

 

[G.Patton]

@Czekamnalepszedni
Hello, yes, there is clearly said about this in the article and synthesis reaction scheme
Yes, the synthesis quite simple

 

[Rua]

Is it mandatory to apply the HCI gas process? Can I not apply it?

 

[G.Patton]

@Rua Hello, if you want to get NEP hydrochloride salt powder or crystals, you need you use HCl gas or HCl acid anyway.

 

[Rua]

Ethylmine aqueous solution cas no ??

 

[G.Patton]

Ethylmine Aqueous Solution Cas

For those who think it's easier to annoy you than to Google 'Ethylmine aqueous solution cas' themselves.

letmegooglethat.com

 

[Rua]

Hello @G.Patton I will use hydrochloric acid I think I need to use methylamine 40%. I need to add it drop by drop during synthesis. How many degrees should I keep the temperature while adding?

 

[axis]

How much water is ethylamine % 70 or 50?

 

[Rua]

How much water is ethylamine % 70 or 50?

 

[Rua]

instead of ethylamine ethyl acetateCan I use it?

 

[Rua]

@G.Patton Should I use ethylmine aqueous solution or methylmine? Can you give me the cas no. What is the percentage of water?