- Joined
- Jun 12, 2022
- Messages
- 82
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- 30
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- 8
gentlemen, how do we know what volume of 25% NaOh solution should be added? I mean where did this 8 l come from, how to calculate it?
how to calculate it?
For sure there is a way to calculate it, but more important here will be the pH value, when the solution is alkaline enough to release the freebase.
I wonder if it will not be better if in the end you will not add 50% acetic acid to get down from the pH lower and then add a little alkali to these 12… what do you think?
7. The aqueous phase was thereafter extracted with 8 liters of IPA.
gentlemen, I still did not get a reply to point 7. for me, after removing the top layer and adding to the bottom (water) IPA NOTHING HAPPENS. two layers are not formed again
Water and IPA also mix wonderfully, but I read from points 6 and 7 that IPA is added first and then the layer is separated. For me, the question is rather why one does not use water-insoluble petroleum ether instead of the IPA, which would keep the amount of water to be removed smaller. Drying does not take place at all here, for whatever reason ever.
in your opinion, after adding the base and the oil flows out, IPA is added and mixed and then the top layer is pulled off?
Yes, that is how I understood it. Although the use of IPA does not seem optimal to me.
hi i found some old notes regarding this p2np reduction. photo attached View attachment 5308
why the synthesized amphetamine has no power?
everything done as it was written in the recipe. the smell is there, the taste is bitter, and the potency is very weak… what could it be?
Have you done a/b extraction of your product? Probably, you have a lot of side products
Is it practical to just manually turn the vacuum pump of and on when the pressure gets quit low ?
You don't need to adjust pH of amph oil. I told about Amphetamine purification by acid-base extraction. Probably your 13-14 pH value is method measurement error (by pH stripes), I mean that it's okay.so I did. or could it be caused by too high pH of the amine .. I think it is too alkaline. you can hardly see the difference on the strips, but it seems to me that the pH is 13-14
the next time after the reaction is complete, I will want to lower the pH with acetic or hydrochloric acid and slowly raise the pH to 12 with base.
i want to setup everything i need to do this reaction, i am not certain about my vacuum source bc its my first time working with vacuum evaporation, i am looking at a fairly cheap Vacuum pump that is aperently pulling 5 Pa ultimate vacuum.
That is a pretty deep vacuum as far as i understand it, i am getting a 2L Cold trap and am planing to use that with water/salt ice bath to prevent IPA entering my pump but as far as i can see the deeper the vacuum is the colder my cold trap needs to be to prevent solvent entering the pump. Is it practical to just manually turn the vacuum pump of and on when the pressure gets quit low ? Looking at vacuum operations and cold traps specifically i found that quit regularly people use more than one cold trap, is this only to collect residual vapors or is there a secondary use that i dont understand ?
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