Simple methylone synthesis (bk-MDMA)

[karamelosanto]

HI, Thanks for sharing this synthesis, I think is very clear.
I am from South America and here is a little difficult to find DCM. However, I can try to find it in some way. Maybe buying it from china.
I want to ask. Can you put all the regents in a list with quantities to make a little more easy to understand what I must to buy. If is possible with an estimated price.
Thanks!!!

 

[Professor11]

Pode me mandar uma mensagem? Sou da América do Sul também, estou iniciando na produção de Metilona.

 

[Marvin "Popcorn" Sutton]

DCM can be replaced by a more readily available solvent. The quantities of reagents depend on your needs.
I wrote to you on the PM for a more detailed discussion.

 

[bohnaga123]

aku sudah punyaI have contacted you some time ago but have not received a reply, I would like to collaborate with you and currently I am studying MDMA synthesis, could you contact me privately?

 

[Marvin "Popcorn" Sutton]

The table shows the density of 40% methylamine as 0.89g/ cm3, hence 7.18g of pure methylamine gas is obtained in 20ml.
Let us compare the molecular weights of methylamine and its hydrochloride:
M (CH3NH2)HCl = 67.518 g/mol
M CH3NH2 = 31.057 g/mol.
Ratio = 2.174
If you use the proportions from the synthesis, you will need 15.6g of methylamine hydrochloride to replace 20ml of 40% methylamine solution.
Methylamine hydrochloride needs to be dissolved beforehand in the proportion of 1g to 2.5ml water (15.6g and 39ml).
Prepare sodium hydroxide (NaOH) solution of 18g and 54ml water, let it cool and pour it into a flask with 2-bromo-3,4-methylenedioxypropiophenone solution. After that, add methylamine hydrochloride solution. Then continue according to the instructions.

 

[arundo]

Hello, I'm doing the math, and I see that the molar ratio of NaOH isn't equivalent with methylamine HCl. It doubles. It's for some reason?

 

[poo]

What should be the concentration of the sodium hydroxide (NaOH) ?

 

[antrax]

I want to try the chemical synthesis of bk-MDMA I already bought all the necessary chemicals, I will start directly from the precursor 2-Bromo-3',4'-(methylenedioxy)propiophenone (CAS Number: 52190-28-0) since I already bought it from a Chinese chemical supplier and I paid 280 dollars for 1kg with shipping included, from 25 kg I will pay 200 dollars for each kg.
kg with shipping included.

I bought the methylamine 40% aqueous solution from a Polish supplier, although it was not an easy task to find it, and the other chemical products are easily available in the national market, except for 36% hydrochloric acid, I only found 35-38 % analytical grade hydrochloric acid which I bought, magnesium sulfate I didn't know which one to buy so I bought the anhydrous.

Ácido clorhídrico 35-38% AGR Reag.Ph.Eur.

HCl

www.letslab.com

Magnesio Sulfato anhidro GLR

MgSO4

www.letslab.com

I will follow the following chemical synthesis of bk-MDMA since it seems easier than the one you shared, but I may be wrong, I would like you to give me your opinion.

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/threads/bk-mdma-synthesis-easy-and-fast-method.6423/

Thank you!!

 

[Eddybeaumont]

hello mate, can you give me an address to buy cas 52190-28-0 please?

 

[Osmosis Vanderwaal]

Someone asked me the other day about using sesamol to get MD-P1P, and it looked possible. Any opinion on that?

 

[William Dampier]

Doubtful route. If someone says how to do it simple, we will be glad.

 

[Wan Jack]

In a reaction kettle equipped with a condensing reflux, stirring, dropping and heating device, 111.3 g of catechol, 500 ml of dichloroethane and 166 g of ZnCl2 were added, stirred, cooled to 0-5°C, and 140 g of propionyl chloride was slowly added dropwise for about 2 hours, then the temperature was raised to 20°C and the reaction was continued for 15 hours. After the reaction was completed, water was added for dilution, and the organic phase was separated. The organic phase was sequentially acid-washed and washed with water, dried with sodium sulfate, desolventized, and the residue was recrystallized from ethanol to obtain 144 g of solid 3,4-dihydroxypropiophenone with a melting point of 145-146°C, a content of 98%, and a yield of 85%.

 

[William Dampier]

Yes, this method is more understandable. But I heard that you can use iodine as a Lewis acid catalyst. For more moderate conditions. I did not have time to check it, but I think that there is need study. Because the chinese intermediate of this substance have is of very poor quality, I think they have problems with the synthesis.

 

[Wan Jack]

Please refer to the next step( Patent: US1964973 , 1932)

 

[Wan Jack]

Sesamol Obtain MD-P1P No relevant information found

 

[Wan Jack]

Preparation of 3,4-methylenedioxypropiophenone
Methanesulfonic acid (MSA, 288 g) and propionic anhydride (156 g) were charged into a 1-liter reaction flask. The mixture was cooled to 0°C and 122 g of 3,4-methylenedioxybenzene (MDB) was added under stirring. The reaction mass was maintained at 0°C to 5°C for 4 hours under stirring. After the completion of the reaction, the reaction mass was diluted with water and the 3,4-methylenedioxypropiophenone product and unreacted MDB were extracted using toluene. The toluene layer was distilled to recover 13 g of unreacted MDB and obtain 142 g of 3',4'-methylenedioxypropiophenone (GC purity > 98%, yield 131% w/w based on consumed MDB). The water layer was distilled to recover 273 g of MSA (purity > 98%), which could be reused in subsequent batches.

 

[cherryroyal]

N methypyroldine or n methyl 2 pyroldine used

 

[cherryroyal]

cas 872-50-4 is n methyl 2 pyroldine or n methypyroldine is used
Because one is forming amine

 

[Osmosis Vanderwaal]

There's no pyrrolidine Moiety and mdma/bk-mdma if you laminated it with pyrrolidine you would have (I've got to build it to tell)

]Also kno2n as https://en.wikipedia.org/wiki/3',4'-Methylenedioxy-α-pyrrolidinopropiophenone

 

[cherryroyal]

So which can be used ?

 

[cherryroyal]

Nh-ch3
|
Ch3
Bond is needed

 

[Osmosis Vanderwaal]

That's not what you need. you need

C-NH-CH3
I
CH3
The bromination with hBR adds an alpha bromine, which gets methylated to an alpha methyl and methylamine provides both the amino and the terminal methyl. methanol and an acid catalyst can often carry out a methylation, but you need an lamination too, such using methylamine is doing 2 things for the price of 1

 

[Osmosis Vanderwaal]

This assumes you are reducing the keto and methylamino the alpha carbon, which is the standard procedure for most cathinones

 

[cherryroyal]

Ok thank you and share some knowledge on how to remove hydroxyl group after making bk mdmc
Two steps are mentioned regarding this in open source
Dehydration elimination step
And
Reaction of double bond ketone is mentioned will this work in removing hydroxyl group alcohol