1-Phenyl-2-propanon (P2P) Leuckart-aminering til amfetamin og metamfetamin. Smale skala.

[Selassi]

Swim fik et spørgsmål om en anden variation af denne metode:

Efter det første trin (kogning med myresyre og formamid) koger de nu igen den organiske fase med vand og NaOH i stedet for tilbagesvaling med HCl.

Kan nogen forklare mig beregningerne af dette anderledes andet trin for mig? Swim har aldrig gjort det på denne måde, men det ser ud til at spare en masse tid i modsætning til oldschool-metoden med tilbagesvaling af HCl.

Hvilken styrke af kaustik/vand og hvor meget tilføres reaktoren pr. liter produkt?
Hvor længe skal man koge denne reaktionsblanding ved hvilken temperatur?

 

[waltjr5858]

You can do hydrolysis with a base or an acid...

 

[Curiousonion]

Hvorfor er udbyttet så lavt, er der nogen, der har en metode til metamfetamin med højere udbytte?

 

[Chemdog010297]

Red p, maybe aluminum

 

[Saul]

det er ikke rigtig forkert info den specialefyr laver store fejl

Ammoniumcarbonat bruges aldrig direkte sammen med p2p.
Først fremstilles ammoniumformiat.
Ammoniumformatet fremstilles nemt via ammoniumkarbonat og myresyre. Titrer
til en fin pH-værdi på 7 og fjern vandet.
Først derefter kan det bruges sammen med p2p.

 

[waltjr5858]

Yes ammonium carbonate can completely be used in this reaction directly it's actually a very popular method in many countries and makes ammonium formate in situ.... if you're not 100% sure what you're saying on here don't

 

[G.Patton]

Bruger du tilbagesvalingskondensator og stinkskab?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[waltjr5858]

Ok... but in general then what would happen to the resulting solution if spun up with 30% peroxide?

 

[William Dampier]

Brugen af en ekstra mængde vand i Leuckart-reaktionen kan øge udbyttet. Den, der har gjort det, kan skrive om det her.

 

[TheNut22]

Ja, i Leuckart skal man sørge for, at der slet ikke er noget vand.

 

[southcost]

But we have a 12% water at least in our formic acid, isn't it?

 

[TheNut22]

Jeg lavede mine stærkere hydrogenperoxider af 12 % H2O2. Jeg fordampede bare forsigtigt vand fra det.
Jeg bad om beregninger fra AI-robotassistenten i kemi. Den er god til beregninger, men forvent ikke at få rigtige svar
fra halogeneringer eller lignende ...

 

[loadingST]

Jeg har stadig ikke prøvet reaktionen, men med god hydrolyse med KOH og derefter med HCL burde det give et højt udbytte, og jeg er bange for at arbejde med H2O2 for ikke at danne nogen eksplosive peroxider og ved destilation for ikke at eksplodere.

 

[William Dampier]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William Dampier]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking

 

[waltjr5858]

I saw the same thing and nobody has an answer for it but it was done by actual professional chemist.... not clandestine hackers so id say its there for a reason but it will work without it. Probably to kill off so.e kind of side product or something.

 

[YenaneY]

I think it really is because the hydrogen peroxide helps promote the reaction, but the reaction of deformylation is generally easier on tertiary amines compared with secondary ones, which is why it happens more readily if N-methylformamide is used for methamphetamine.

 

[Pinkbay]

sir, In step 3, is heating required?

 

[rampage]

can you replace n-methylformamide with dimethylformamide?

 

[waltjr5858]

I don't think so