JWH-018 synthesis. Small scale.

[WillD]

1-naphthoyl chloride substituted - 4-methoxy or 4-ethyl -1-naphthoyl chlorides. 1-Adamantanecarbonyl chloride, 2-Iodobenzoyl chloride, 2,2,3,3-Tetramethylcyclopropanecarbonyl chloride, etc

 

[Khaled]

The substitute for naphthoyl chloride is benzoyl chloride 99%.

 

[WillD]

Yes, of course it is better to buy chloride than to make it, not the most pleasant procedure.

 

[Khaled]

The substitute for naphthoyl chloride is benzoyl chloride 99%.

 

[WillD]

MW oven, beakers, scales, grinders, filters, etc.
PS: Who synthesizes ADBB-noids with main reagent (with potassium carbonate), can try this synthesis starting from step 4

 

[阿卡Mario]

1. can sealed bottles explode? 2. is a microwave oven good for home use?

 

[WillD]

The powders must be crushed in one diameter to evenly distribute.
Vials are used for a microwave reactor. For a household microwave, we use a beakers and short, but frequent irradiation.

 

[Bigwest]

Can someone explain to me how to Split the time of irradiation when i using a household microwave

 

[SD850IS]

Inquiring...What are the differential(s) between JWH-018 and UR-144
including, but not limiting to strength. Which appreciated!!! I am "chumping at the bit"
waiting for your response/clarification.

​

 

[G.Patton]

Hello, it is better to open Pharmacology section. The topics about JWH-018 and UR-144 are completely described. You can compare them.

 

[D4ftmonk]

In the article it is stated that JWH can be used in liquid, which means that for small scale production it cannot be used to be mixed into tobacco?

 

[G.Patton]

Hi. Why not?

 

[阿卡Mario]

Do you need heating when reflow？

 

[MrSung]

I have all the precursors to test this microwave synthesis because the chemistry sounds very promising and educative but i am having no Aluminium Oxide.

I had wanted to synthesise the Aluminum oxide (Al2O3) but i have only NaOH and H2SO4 but no HCL, and i am of the conviction that i will need HCL for a cleaner synthesis pathway.

Is/are there any other reagent/s i can substitute for Aluminum oxide (Al2O3)?

 

[HerrHaber]

Hi Aluminium trioxide (Al2O3) also known as alumina is really easy to source from dentistry materials shop, dental technicians use different granulations of it for a procedure normally called sanding where this stuff is sprayed with pressure on hard (metal, ceramic or polymer) materials, mainly prosthetic teeth or parts in order to polish the surface. It's pretty cheap chemical but expect to have it in big 3-5L packages and also dentistry stuff are more expensive than just regular chemicals. Just pay a visit to a dental technician's lab and just ask for a cupfull for free, maybe you will encounter a kind enough person to just give it off, ofer them a little money if you think it's appropriate. Hint: you can also use alumina for column chromatohraphy this is it's main use in the organic chemistry lab and also to adsorb expensive catalysts for them to be filtered and then reused.

 

[HerrHaber]

Forgot to mention that alumina is very oftenly used in microwave chemistry (especioally when working with a household device since proffesional MW reactors are extremely expensive even compared to fancyest batch reactors) since they have a shielding (I hope I'm right) effect, or anyway, it's often mentioned as a "bath" type pf thing so the reactor stays in a beaker filled with a certain amount of Al2O3. Hope this helps.

 

[MrSung]

@H, you have given me a reason to at least visit a dental shop tomorrow. I appreciate the info, very usefull. Thumbs up mate!

 

[HerrHaber]

Well I'm glad I gave you a reliable hint (I succesfully performed column chromatography with alumina that was offered to me by my dentist who is also qualified technician and makes the prosthetics for his patients himself). Shops that supply these often chemicals and even more often mixtures also instruments and equipment don't have the usual chemical supply politics and many useful things of interest for chemists can be found there but some are pricy if lets say they are destined to be used directly in the patients mouth but the supplies for technicians are much more affordable. You will have to decide the granulation of the alumina (mesh) that is something you can sort out.

 

[Bigwest]

I have all the ingredients, i am trying to Split the 8 & 4 minutes of irradiation on 2 by 2 minutes and let thé product cooled between them but its not working. Could somone help with that pls.

 

[G.Patton]

You can try to split it to 10-25 sec. Don't cool them too much.

 

[Bigwest]

I try to Split it to 10 seconds first not working then i try to Split 20 by 20 sec. and after this thé effect is too weak nothing to compared with jwh 018 even with thc.!!?

 

[Bigwest]

Note that 1 naphthoyl chloride has turned into solid because of the temperature drop.

 

[G.Patton]

Are you sure in your reagents? Have you checked their mp?

 

[G.Patton]

Hi, I didn't. I asked about this synthesis for you from William. Ty for your feedback.

 

[Bigwest]

I write to william in pm. I hope hé gonna reply. But i am sûre that Theres somthing wrong.

 

[mkcvnvn]

Thanks