1-fenüül-2-propanooni (P2P) Leuckarti aminatsioon amfetamiiniks ja metamfetamiiniks. Smale skaala.

[Selassi]

Swim sai küsimuse seoses selle meetodi erineva variatsiooniga:

Pärast esimest etappi (keetmine koos sipelghappe ja formamiidiga) keedetakse nüüd orgaanilist faasi uuesti vee ja NaOH-ga, selle asemel, et uuesti keeta HCl-ga.

Kas keegi oskab mulle selgitada selle erineva teise etapi metoodikat? Swim ei ole seda kunagi nii teinud, kuid tundub, et see säästab palju aega võrreldes vanakooli meetodiga HCl tagasivooluga.

Millise tugevusega leeliselisand/vesi ja kui palju viiakse reaktorisse ühe L toote kohta?
Kui kaua peaks seda reaktsioonisegu keema ja millisel temperatuuril?

 

[waltjr5858]

You can do hydrolysis with a base or an acid...

 

[Curiousonion]

Miks nii madal saagis selle jaoks, kas kellelgi on metamfetamiini jaoks suurem saagise meetod?

 

[Chemdog010297]

Red p, maybe aluminum

 

[Saul]

mis ei ole õige vale info, et lõputöö mees teeb suuri vigu

ammooniumkarbonaati ei kasutata kunagi otse p2p.
Kõigepealt tehakse ammooniumformiaati.
Ammooniumformaati saab kergesti valmistada ammooniumkarbonaadi ja sipelghappe kaudu. Tiitritakse
mõnusalt pH 7-ni ja eemaldage vesi.
Alles siis saab seda kasutada koos p2p-ga.

 

[waltjr5858]

Yes ammonium carbonate can completely be used in this reaction directly it's actually a very popular method in many countries and makes ammonium formate in situ.... if you're not 100% sure what you're saying on here don't

 

[G.Patton]

Kas te kasutate reflukskondensaatorit ja suitsutuskappi?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[waltjr5858]

Ok... but in general then what would happen to the resulting solution if spun up with 30% peroxide?

 

[William Dampier]

Täiendava veekoguse kasutamine Leuckarti reaktsioonis võib suurendada saagist. Kes seda tegi, võib sellest kirjutada siin.

 

[TheNut22]

Jah. Leuckartis tuleb veenduda, et vett ei ole üldse.

 

[southcost]

But we have a 12% water at least in our formic acid, isn't it?

 

[TheNut22]

Ma tegin oma tugevamad vesinikperoksiidid 12% H2O2-st. Ma lihtsalt aurustasin sellest ettevaatlikult vett.
Küsisin arvutusi AI-roboti assistendilt keemias. See on arvutustes hea, aga ärge oodake, et saate õigeid vastuseid
halogeenidest vms ...

 

[loadingST]

Ma veel havent proovinud reaktsiooni, kuid hea hüdrolüüsi KOH ja siis HCL see shoud anda kõrge saagise, ja im kardan töö h2o2 dont moodustada mingeid plahvatusohtlik peroksiidide ja pärast destilatsiooni dont plahvatada

 

[William Dampier]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William Dampier]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking

 

[waltjr5858]

I saw the same thing and nobody has an answer for it but it was done by actual professional chemist.... not clandestine hackers so id say its there for a reason but it will work without it. Probably to kill off so.e kind of side product or something.

 

[YenaneY]

I think it really is because the hydrogen peroxide helps promote the reaction, but the reaction of deformylation is generally easier on tertiary amines compared with secondary ones, which is why it happens more readily if N-methylformamide is used for methamphetamine.

 

[Pinkbay]

sir, In step 3, is heating required?

 

[rampage]

can you replace n-methylformamide with dimethylformamide?

 

[waltjr5858]

I don't think so