1-fenil-2-propanona (P2P) Leukarta aminācija līdz amfetamīnam un metamfetamīnam. Smalkā skala.

[Selassi]

Peldēšana saņēma jautājumu par citu šīs metodes variantu:

Pēc pirmā posma (vārīšanas ar skudrskābi un formamīdu) tagad organisko fāzi atkal vāra ar ūdeni un NaOH, nevis refluksa ar HCl.

Vai kāds var man izskaidrot šā atšķirīgā otrā posma metriku? Peldēšana nekad nav veikta šādā veidā, bet šķiet, ka tā ietaupa daudz laika atšķirībā no vecās skolas metodes ar HCl atdalīšanu.

Kāda stipruma kodīgā viela/ūdens un cik daudz tiek ievadīts reaktorā uz vienu litru produkta?
Cik ilgi būtu jāvāra šis reakcijas maisījums un kādā temperatūrā?

 

[waltjr5858]

You can do hydrolysis with a base or an acid...

 

[Curiousonion]

Kāpēc tik zems iznākums šim, vai kādam ir metode ar lielāku iznākumu metamfetamīna iegūšanai?

 

[Chemdog010297]

Red p, maybe aluminum

 

[Saul]

ka nav pareizi nepareizi nepareizi info, ka tēzes puisis pieļauj lielas kļūdas

amonija karbonātu nekad neizmanto tieši ar p2p.
Vispirms tiek izgatavots amonija formāts.
Amonija formātu var viegli pagatavot, izmantojot amonija karbonātu un skudrskābi. Titrāts
līdz pH 7 un noņem ūdeni.
Tikai tad to var izmantot ar p2p

 

[waltjr5858]

Yes ammonium carbonate can completely be used in this reaction directly it's actually a very popular method in many countries and makes ammonium formate in situ.... if you're not 100% sure what you're saying on here don't

 

[G.Patton]

Vai jūs izmantojat atgaitas kondensatoru un tvaika nosūcēju?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[waltjr5858]

Ok... but in general then what would happen to the resulting solution if spun up with 30% peroxide?

 

[William Dampier]

Papildu ūdens daudzuma izmantošana Leikarta reakcijā var palielināt iznākumu. Kas to izdarīja, var par to uzrakstīt šeit.

 

[TheNut22]

Jā. Leikartā ir jāpārliecinās, ka tajā vispār nav ūdens.

 

[southcost]

But we have a 12% water at least in our formic acid, isn't it?

 

[TheNut22]

Es izgatavoju savus stingrākos ūdeņraža peroksīdus no 12% H2O2. Es vienkārši rūpīgi iztvaikoju no tā ūdeni.
Es lūdzu aprēķinus no mākslīgā intelekta robota palīga ķīmijā. Tas labi veic aprēķinus, bet negaidiet, ka saņemsiet pareizas atbildes.
no halogenēšanas vai tamlīdzīgi ...

 

[loadingST]

Es vēl neesmu izmēģinājis reakciju, bet ar labu hidrolīzi ar KOH un pēc tam ar HCL tas dotu augstu iznākumu, un es baidos, ka strādājot ar h2o2, lai neveidotos sprādzienbīstami peroksīdi un pēc destilācijas nenotiktu sprādziens.

 

[William Dampier]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William Dampier]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking

 

[waltjr5858]

I saw the same thing and nobody has an answer for it but it was done by actual professional chemist.... not clandestine hackers so id say its there for a reason but it will work without it. Probably to kill off so.e kind of side product or something.

 

[YenaneY]

I think it really is because the hydrogen peroxide helps promote the reaction, but the reaction of deformylation is generally easier on tertiary amines compared with secondary ones, which is why it happens more readily if N-methylformamide is used for methamphetamine.

 

[Pinkbay]

sir, In step 3, is heating required?

 

[rampage]

can you replace n-methylformamide with dimethylformamide?

 

[waltjr5858]

I don't think so