Hi, does anyone know what is the best way to get N-methylpyrrolidone? This is the only thing missing to try this route. thank you in advance. Please PM me if you would not like to share sources in public. Any help would be appreciated guys.
I found in Russian 4 methlypropiophenone in liquid cas not dry is it can be the same. or can I get the right cas number of 4 methylpropiopheone . Which I need
I found in Russian 4 methlypropiophenone in liquid cas not dry is it can be the same. or can I get the right cas number of 4 methylpropiopheone . Which I need
Sorry sir for directly message
Actually I synthesis of mephedrone hydrobromide. All process i done last process when liquid of mfd i kept in freezer from last 48 hr but meph not make dried and solid. When I filter them use of butchner funnel all liquid are same condition. There no solid form left
Main problem is that liquid is in oil base form. How i seperate oil base form from meph liquid. That is my problem . Other wise I don't disturb you sir
I think the vacuum is just used, because it is officially in the manual of the reactor to supply liquids with the help of vacuum. The reaction would be the same without vaccum.
Where would you suggest to sourse this from (for shipping to EU) And the other reagents for this synthesis to. Are chinese vendors good to look into. Maybe even Alibaba…?
Where would you suggest to sourse this from (for shipping to EU) And the other reagents for this synthesis to. Are chinese vendors good to look into. Maybe even Alibaba…?
I do everything according to the film. after separation, I drain the oil from the top layer into a cold beaker, then add 500 ml of frozen acetone and the color starts to change to red and more and more bloody. Ph at this point is around 8.
After gradually adding hydrobromic acid 48%, the elixir begins to change into a dark color, and then, after adding further drops and obtaining a PH between 4-5, the color becomes slightly reddish brown. There is no precipitation reaction of mephedrone salts from the solution at all. The solution is still liquid. what could this be caused by?
Materials
2-Bromo-4'-methylpropiophenone (cas 1451-82-7)
N-Methyl-2-pyrrolidone (NMP; cas 872-50-4)
Methylamine 40% aqueous solution (cas 74-89-5)
Ethyl acetate (cas 141-78-6)
Acetone (cas 67-64-1)
48% hydrobromic acid (cas10035-10-6)
Distilled water
Are these materials and CAS numbers correct?
I don't have acetone and 48% hydrobromic acid, concentrated hydrochloric acid (HCl 36%)
What can I use instead?
Is it necessary to conduct the reaction under vacuum conditions?
Thank you experts for answering me，Thank you so much
Materials
2-Bromo-4'-methylpropiophenone (cas 1451-82-7)
N-Methyl-2-pyrrolidone (NMP; cas 872-50-4)
Methylamine 40% aqueous solution (cas 74-89-5)
Ethyl acetate (cas 141-78-6)
Acetone (cas 67-64-1)
48% hydrobromic acid (cas10035-10-6)
Distilled water
Are these materials and CAS numbers correct?
I don't have acetone and 48% hydrobromic acid, concentrated hydrochloric acid (HCl 36%)
What can I use instead?
Is it necessary to conduct the reaction under vacuum conditions?
Thank you experts for answering me，Thank you so much
For the synthesis you can use different solvents, most common is DCM, I prefer toluene for acidification in water, for acidification in acetone I use xylene. Instead of HBr it's usually used HCl aq.
I never conducted reaction under vacuum.
If you won't have access to MA 40% you can swap it to MA HCl + NaOH solution
Add hydrobromic acid and place in refrigerator for 24 hours，The bottom has crystallized.Why do you even heat the mixture in a water bath?Then filter the ephedrine，Is this step redundant?
