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Hello could someone please test if Oxidizing of Ephedrine to Methcathinone (''Ephedrone'') with H2O2 works.Thank you very much

 
Can I get a help . Lodketon I searched about it haven't find . In which formula can I find . Or other names for this products
 
Hello , I have a question, How much Hydrobromic should be added in this video, it is not written there. Thank you in advance
 
Who can help with the choice of equipment , I need to make a volume of 18 kg per day, which reactor, flasks, vacuum to use ?
 
A solution of isopropyl alcohol and pure water (30:70) was prepared. 30 isopropyl alcohol and 70 water?
 
@Novator @G.Patton Can this be scaled? I like the reagents better than the look of the other mephedrone synths posted. I have a reactor with nice heater/chiller is the problem with scaling the heat generated? What is the target tempurature for this reaction? Thanks
 
Hello, yes it can.

There is no such problem, read the topic about this synthesis. (link under this video)
The link under the video goes to a write up of a different synthesis in nmp. Is there a link to a write up about this synth? I dont see it, would it be ok to try this at 10x scale same ratio of everything? Thanks
 
The link under the video goes to a write up of a different synthesis in nmp. Is there a link to a write up about this synth? I dont see it, would it be ok to try this at 10x scale same ratio of everything? Thanks
You are right. Procedure conditions are same. You can scale all reagents x10 but I strongly recommend you to start from small scale synthesis.
 
The captions sometimes disappear a little bit too quickly for me to read them. It seems like the videos / captions have sped up as time goes on. That being said, I always feel empowered and inspired after watching BB.expert videos, the production values are the absolute top of the genre.
 
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?
 
You are right. Procedure conditions are same. You can scale all reagents x10 but I strongly recommend you to start from small scale synthesis.
Thanks appreciate the help! My problem is I have a 50l reactor and the mixer only works if there is at least 2 liters of liquid, maybe I could just add more Ethyl acetate?
 
It's worth to take smaller vessel, man.
ok I have 5 liter three neck flasks but I dont have an overhead mixer for them just magnetic mantle and it looks like it would be hard for that to stir this mixture properly getting a small reactor could take a few months but if you think it is isnt easy to do a bit bigger I can wait
 
just magnetic mantle
Do you mean magnetic mantle with stirrer? It doesn't take a reactor, you can carry it out in simple one neck flask and stir it manually or shake it manually in case you don't have a magnetic stirrer (it is the best option).
 
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Do you mean magnetic mantle with stirrer? It doesn't take a reactor, you can carry it out in simple one neck flask and stir it manually or shake it manually in case you don't have a magnetic stirrer (it is the best option).
yeah i have mantles with magnetic stirrer I just assumed because the powder product isnt very dissolved and there is a lot of it it might not stir with a stir bar. thanks again for your advice
 
I have a "little problem" with cristalization,if anyone more knowledgeable than me can write me a PM i whould apreciate it.
Best regards
 
I have a "little problem" with cristalization,if anyone more knowledgeable than me can write me a PM i whould apreciate it.
Best regards
With this chem or what chem do you refer to? Usually recreationalization and crystallization can come in a a and b process where acid base is used and solidifying into a liquid and the substance going into the Aquarius layer and or the acidic layer and separating out the gun can do and then using if it's based in aqueous layer for instance like today methamphetamine then you would use something like everclear very very little bit you would use acetone and at the very very least try to avoid but if needed a few drops of distilled water depending on the amount of your batch will vary independent on a lot of things you mainly want the more space it has to grow like he's in the crystals the bigger the crystals will be some substances don't properly crystallize a certain way unless they're salts and or it is very strong chemical to chemical it really does but for the simplicity of things it depends on what version of you have of the substance there's a lot of factors it may be if you could be a little bit more detailed I can try to help you out
 
Lol, I'm using voice to text so please forgive me I also went to and I missed out on the muriatic acid as the acidic layer is usually you know radic acid and we're just fine you can even up for the clean the Mirada acid but distilling it you know there's that it's just way some of the drunken nonsense you don't want but it is pretty good and you know then you got to watch your page levels and all that good stuff but just thought I'd throw it in there and mention that so if for some reason my wording is coming off as pretty stupid and dumb and ignorant it's probably because voice to text is being janky
 
@G.Patton @Novator how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks
 
how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks
It takes about 20 min as described in the topic. Are you sure that you've added correct amount of methylamine free base? Have you tried to finish your procedure in accordance with guide? Please, continue in the topic comment section (you can mark me to remind).
 
It takes about 20 min as described in the topic. Are you sure that you've added correct amount of methylamine free base? Have you tried to finish your procedure in accordance with guide? Please, continue in the topic comment section (you can mark me to remind).
I had to make the methylamine 40% from methylamine HCL. I used a post from this forum however the molar ratios seemed a little low in NaOH (40g MethylAmhcl 17g Naoh) but the poster said they had tried many recipes and found only slow addition of NaOH until Ph 12 produced proper results. When the reaction did not proceed quickly I slowly added more methylamine 40% until I had reached a 3x excess (750ml instead of 250ml).

I am following up on crystallization steps today hopefully they worked. Is there good information on the forum for making 40% Methylamine? The info seems to be asked for a lot because the HCl form is easier to get. Thank you!!
 
I used a post from this forum however the molar ratios seemed a little low in NaOH (40g MethylAmhcl 17g Naoh)
It seems that you take not enough NaOH. 40g Methylamine*HCl is 0.59 mole and 17 g NaOH is 0.425 moles. You have to take about the same or more moles of NaOH, man. What post do you mean? In addition, take into account that MeNH2 is very volatile substance and evaporates quite fast.

Is there good information on the forum for making 40% Methylamine?
 
It seems that you take not enough NaOH. 40g Methylamine*HCl is 0.59 mole and 17 g NaOH is 0.425 moles. You have to take about the same or more moles of NaOH, man. What post do you mean? In addition, take into account that MeNH2 is very volatile substance and evaporates quite fast.


This post. He seemed like he had done a bunch of specific work so even though the molar ratios were off I tried it. Your post relates to bubbling into methanol and the synth I am using calls for it in water. Thanks. The thread i followed was https://bbgate.com/threads/using-methylamine-hcl-successfully-in-4mmc-synthesis.5641/
 
@G.Patton @Novator how long roughly does amination usually take? What temperature does it normally heat to? I tried this at the scale listed, magnetic stirrer was no problem, the color change was not the same as the video, it slowly changed to green/yellow over two hours with a slight exothermic reaction from 13c to 22c, I added a little heat (50c) to try and cause it to react more, it slowly went to yellow/orange and then orange/brown over 20 hours. I was using homemade 40% aqueous methylamine solution that I made from methylamine hcl and naoh and I slowly adding 3x extra in case the solution was not a real 40%. Thanks
I have encountered the same problem as you. Using methylamine hydrochloride and sodium hydroxide also requires heating, and the color changes from green to yellow. Did you synthesize iodone by yourself? Did you finally synthesize 4-MMC successfully?
 
Does this description tell you something?
Dear Mr. Patton, I have a curiosity which you have advised me to satisfy. Can you explain which solvents to use and create conditions for the synthesis of Clephedron from 2-brom-3-chloropropiophenon? I understand that this synthesis is similar to the synthesis of Mephedrone, but the precursors of these methcathinones have different states of aggregation and I think that this fact can affect the choice of solvent to some extent. I will be very grateful if you explain this synthesis?
 
Dear Mr. Patton, I have a curiosity which you have advised me to satisfy. Can you explain which solvents to use and create conditions for the synthesis of Clephedron from 2-brom-3-chloropropiophenon? I understand that this synthesis is similar to the synthesis of Mephedrone, but the precursors of these methcathinones have different states of aggregation and I think that this fact can affect the choice of solvent to some extent. I will be very grateful if you explain this synthesis?
Hello, you need 2-bromo-4'-chloropropiophenone CAS 877-37-2 for synthesis of 4-Chloromethcathinone (Clephedrone). So far as solvent in this synthesis concerned, I can't answer you because Idk for sure. I would try same solvents as for 4-mmc at first. I haven't found exact information about this synthesis.
 
If I replace the raw material with phenyl(2-propyl)ketone (CAS 611-70-1), does it mean that I can directly synthesize methcathinone through this operation?
no buddy. this reaction is sn2, so you need a nucleophilic agent, and your ketone is not.
 
Hello, you need 2-bromo-4'-chloropropiophenone CAS 877-37-2 for synthesis of 4-Chloromethcathinone (Clephedrone). So far as solvent in this synthesis concerned, I can't answer you because Idk for sure. I would try same solvents as for 4-mmc at first. I haven't found exact information about this synthesis.
my respect 👋 the fact is that I have 3-chloropropiophenone (cas: 34911-51-8) available, which differs from 4-chloropropiophenone only in that it is a liquid, but I want to get exactly 3-cmc. So thank you very much for your response to the previous post. And on this occasion, I have the last 2 questions: 1. What role does NMP play in such syntheses and is it possible to do without it at all? and 2. Did you choose the quantities of reagents (participants in the reaction) based on the coefficients in the equation of this reaction or from the consideration that a cheap component should be taken in excess?
 
Based on this video, this synthesis uses 0.55mol (125g) BK-4 and 2.9mol (250ml*0.9g/ml*0.4=90g) methylamine. What caused the need for an almost sixfold excess of methylamine? And can this negatively affect the yield of the final product? Or maybe I'm wrong in my calculations?
 
1. What role does NMP play in such syntheses and is it possible to do without it at all?
This play role of dipolar aprotic solvents. Have you read this post? https://bbgate.com/threads/mephedrone-synthesis-4-mmc-in-nmp-solvent-large-scale.231/
2. Did you choose the quantities of reagents (participants in the reaction) based on the coefficients in the equation of this reaction or from the consideration that a cheap component should be taken in excess?
It was written in accordance with the reaction equation and great synthesis experience.
What caused the need for an almost sixfold excess of methylamine?
Methylamine in this reaction works as N-nucleophile and base catalyst
And can this negatively affect the yield of the final product?
Are you talking about the excess of methylamine? You can get rid of this quite easy during water washing and/or evaporation after synthesis.
 
This play role of dipolar aprotic solvents. Have you read this post? https://bbgate.com/threads/mephedrone-synthesis-4-mmc-in-nmp-solvent-large-scale.231/

It was written in accordance with the reaction equation and great synthesis experience.

Methylamine in this reaction works as N-nucleophile and base catalyst

Are you talking about the excess of methylamine? You can get rid of this quite easy during water washing and/or evaporation after synthesis.
quite detailed and clear answer, thank you very much. Armed with this information, I am going to conquer this substance right now.👋😉I will return with a shield, or on it.🤭
 
I know it indicated in text that reactions are provided without a vacuum. I just wanted to confirm if this means that the reaction can be complete at normal atmospheric pressure? And that a sealed reaction vessel isnt required?
 
Great job I want to know is mephedrone similar to cocaine? Does it have the same effects and does it also cause greenness in the tongue like cocaine? And can it be consumed in powder form without becoming crystal?
 
Great job I want to know is mephedrone similar to cocaine? Does it have the same effects and does it also cause greenness in the tongue like cocaine? And can it be consumed in powder form without becoming crystal?
Mephedrone is similar in action to cocaine and mdma. With nosal use, the duration of action is 40 minutes, causes strong euphoria with light stimulation. Very strongly stimulates sexual desire.
 
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Hello, please, I want to buy large quantities of materials from your site, but I sent you an email and none of you answered me.
 
Can you give a list of required equipment to produce mephedrone crystals? And a list of raw materials needed?
 
Can I get a list of required equipment to produce mephedrone crystals? And a list of raw materials needed as well. Appreciate.
 
Hi guys
I leave in iran
I cant find mephedron here
I want to make it
And my question
Is it hard to find substance for make it?
I mean the first parts of it
 
What exactly is lodketone? I can't find it anywhere.
idoketone refers to the ideal starting material 2-iodo-4-methylpropiophenone or 2-bromo-4-methylpropiophenone which are both classified as ketones using organic chemistry functional grouping. But it should be said if you do not know what an idoketone is, you probably should not be playing with chemicals. which is also probably the reason more than one person has asked that question on this thread and no one is answering them. it is the question only someone with absolutely no knowledge of chemistry would ask. go take some organic chemistry classes at ur local university or whatever then come back MrCook
 
Thank you a lot. :)
I already know the video. I just bought all reagents for the video starting with the Bromoketone.
Later I realized, that the route shown in the video by starting from Iodketon is much more attractive because of a smaller amount of different chemicals. Best greetings
 
Do you know, why so much NMP is used in one of these reactions?
When I compare the videos, it is possible to do this synthesis without NMP as well.
I have heard, that you get higher yields and better product, in the presens of NMP or DMSO as second solvent.
Is this correct?
 
Sorry for my uncertain reply, yes, you can. There is video tutorial how to. Open video section please.
When I copy this Iodketone route by using the Bromketone. Thank I don't have the colour-changes.
I stopped Methylamine-reaction after I checked that the Temperature is going down.
It was after 32minutes.
In the end two layers seperated. Just during the process, there was not as strong colours like in this video.
 
Do you know, why so much NMP is used in one of these reactions?
Hello, NMP is not used in this video. If you are talking about this synthesis, it is reasoned by the reaction condition.
When I copy this Iodketone route by using the Bromketone. Thank I don't have the colour-changes.
I stopped Methylamine-reaction after I checked that the Temperature is going down.
It was after 32minutes.
In the end two layers seperated. Just during the process, there was not as strong colours like in this video.
Please, write me your issue in DM. Not here. Write there detailed explanation of your procedures.
 
idoketone refers to the ideal starting material 2-iodo-4-methylpropiophenone or 2-bromo-4-methylpropiophenone which are both classified as ketones using organic chemistry functional grouping. But it should be said if you do not know what an idoketone is, you probably should not be playing with chemicals. which is also probably the reason more than one person has asked that question on this thread and no one is answering them. it is the question only someone with absolutely no knowledge of chemistry would ask. go take some organic chemistry classes at ur local university or whatever then come back MrCook
Ok, thank you a lot, I'll consider that.
 

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Synthesis of Methcathinones
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