Mephedrone Synthesis: Step-by-Step Guide & Crystallization Techniques

Mephedrone Synthesis: Crafting Crystals with Precision

Introduction: Crafting Mephedrone

Unveil a synthesis method for mephedrone that seamlessly balances simplicity, efficiency, and high yield. This time-tested procedure, born from the wealth of knowledge on the legendary Hive forum, pays homage to the collective wisdom of countless contributors.

Reaction

Reaction: A Meticulous Choreography

Dance of the Elements

  1. Gather the Ensemble: Prepare your reagents - 2-bromo-4'-methylpropiophenone (CAS 1451-82-7) 500 g, Methylamine 40% aq 750ml, Hydrochloric acid (HCl 37%) approximately 250 ml, Distilled water, Dichloromethane 2,3l, and Tetrahydrofurane (THF) or Aceton.
  2. Choreograph the Flask: Pour 1.5 liters of Dichloromethane (DCM) into the reactor/flask and attach a condenser.
  3. Enter the Star: Add 2-bromo-4'-methylpropiophenone 500 g (CAS 1451-82-7) and stir until it's fully dissolved.
  4. Guest of Honor: Introduce Methylamine 40% aq, 750ml slowly via a drip funnel.
  5. The Dance Begins: Stir the mixture for 2 ½ hours at 38 °C.
  6. Curtain Call: Quench the reaction by adding 7000ml of ice-cold clean tap water.
  7. Intermezzo: Stir the mixture for 1-2 minutes, then separate the DCM layer.
  8. The Residue's Turn: Extract the remaining freebase with 500 ml DCM.
  9. Rinse and Repeat: Wash the combined organic layers twice with 300 ml of water.
  10. A Twist of Acid: Acidify the combined washed organic layers with 2 M hydrochloric acid until reaching pH 5.5-6 with constant stirring.
  11. A Final Rinse: Wash the acidic extract with 300 ml DCM and evaporate the water under vacuum until a viscous liquid forms.
  12. The Grand Finale: Pour the mixture into a buchner funnel, carefully filter, and then apply vacuum until you obtain an off-white solid.
  13. The Encore: Rinse the crude mephedrone hydrochloride thoroughly with cold THF (acetone can be used if THF isn't available).
  14. The Spotlight: Place the washed product in a Pyrex dish and dry it until a constant weight is achieved.

The Ovation: Impressive Yield

The result of this meticulously orchestrated synthesis is an impressive yield of 310.57g, representing 79.59% of the theoretical yield.

Mephedrone

Additional Insights: The Fascination of Mephedrone Synthesis

Mephedrone synthesis, while a subject of concern due to its association with designer drugs, is also an intricate and fascinating field of study. This process underscores the intricate dance between reagents, temperatures, and meticulous procedures required to produce crystalline compounds. Furthermore, it highlights the need for responsible research and awareness about the consequences of engaging in the synthesis of controlled substances.

  1. EHRMANTRAUT

    My first synthesis of mephedrone on DCM. + photos.

    I am glad to welcome you. So, my report on the synthesis of mephedrone. write without mood because at the end of the synthesis was made a mistake. about this you will learn at the end of the article. and so everything in order. I got a tester for 4mmms. It contained methylamine, bk4, acetone...
  2. K-Cyanide

    Mephedrone (4-MMC) synthesis; easy to perform- high yielding

    Introduction: In the following, forum members will be presented with a synthesis that is very easy to perform, does not take much time, and gives an exceptionally high yield. The method is a result of many years of experience and inputs from various sources that go back to the times of the...
  3. 4-MMC (mephedrone) synthesis. Complete video tutorial.

    4-MMC (mephedrone) synthesis. Complete video tutorial.

    https://bbgate.com/threads/4-mmc-mephedrone-synthesis-complete-video-tutorial.616/
  4. William Dampier

    Mephedrone synthesis (4-MMC) in NMP solvent. Large scale.

    Reaction scheme: Reagents: 2-Bromo-4'-methylpropiophenone (cas 1451-82-7) - 5 kg; n-Methyl-2-pyrrolidone (NMP; cas 872-50-4) - 20 L; Methyl amine 40% aq. solution (cas 74-89-5) - 8 L; Benzene - 20 L; Acetone - 30 L; Hydrochloric acid con. aq. solution (HCl 36%) ~ 1.5 L; Distilled water - 20...
  5. Marvin "Popcorn" Sutton

    4-MMC (mephedrone) synthesis. Bromination in dichlormethane.

    We'll consider mephedrone (4MMC) synthesis in this article. Dichloromethane (DCM) is used as a solvent. It has a low boiling point (~40 °C) and synthesis procedures take a little time. Work conditions: Air temperature 20-24 ºC; Relative humidity <60%; Well-ventilated room (with air...
  6. William Dampier

    4'-Methylpropiophenone iodination to 2-iodo-4'-methylpropiophenone by iodine/cooper(II) oxide. Video manual.

    Reaction scheme: Reagents: 4'-Methylpropiophenone (cas 5337-93-9) 5 kg; Сooper(II) oxide (CuO) 2.7 kg; Isopropyl alcohol (IPA) 50 l; Iodine 6.5 kg; Equipment and glassware: 100 L Batch reactor, which is equipped with drip funnel, top stirrer, thermometer, temperature control system...
  7. William Dampier

    4′-Methylpropiophenone bromination to 2-bromo-4'-methylpropiophenone. Large scale.

    Reaction scheme: Reagents: 4′-Methylpropiophenone (cas 5337-93-9) 1000 g; Hydrobromic acid 48% aq. 1300 g; Hydrogen peroxide (H2O2) 35% 750 g; Sodium bicarbonate (NaHCO3); Distilled water; Equipment and glassware: Three necked round bottom flask 5 L; Retort stand and clamp for securing...
  8. William Dampier

    Mephedrone (4-MMC) synthesis from haloketone in ethyl acetate. 1-10 kg Scale.

    Reaction scheme: Reagents: 1. 4'-Methylpropiophenone (cas 5337-93-9) 1 kg; 2. Hydrobromic acid 48% 1300 ml; 3. Hydrogen peroxide 35% 750 ml; 4. Sodium/potassium hydroxide 25% (NaOH/KOH) aqueous solution; 5. Distilled water; 6. Ethyl acetate 6 l; 7. Methylamine 40% aq - 2 l; 8. Acetone - 8 l...
  • Free product samples

    Testing products from new vendors and manufacturers.

    Get free samples for testing now!

  • The BB Forum team is looking for cooperation:

    • Traffic arbitrage specialists
    • Spammers
    • Advertising agencies
    • Bloggers/Vloggers
    • TOR sites directories
    • Creative people who can create viral content
    • Administrators of Telegram Channels and Groups

      We will pay more for your traffic than our competitors! $0.1 per visitor!!!If you are interested in, write to the administrator.
Top