Mephedrone (4-MMC) Synthesis [2B4M, Ethyl Acetate, Methylamine HCl]

[c01db100d_india_mephedron]

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METHYLAMINE (mono) 40%
CAS.nr: 74-89-5

Gerangschikt op

2-Bromo-4-methylpropiophenone 1451-82-7
Acetaat
NaOH
Aceton


Vertel me als we nog iets nodig hebben?

 

[skyler_white]

Pm me from where you ordered?

 

[Alchemistfromthahood]

Hello everyone
I would like to know if everybody who tried this route of synthesis get a clear white product ?
I have to wash it Everytime after putting HCL acid inside
when I put icecold Aceton inside the reactor, It becomes dark red color
does anyone know about this problem

good work Dr.MMX
a very easy structure and easy to understand for everybody who want to learn

 

[Dr. MMX]

acetone cant t be added like "all at once", must be ice cold, should be stirred.

You could have already by products in the freebase from the reaction, it oculd be too long, it could bee to short. Washing could be not ok. I never had red color yet so I cant really tell, as well I cant really tell anything as long there is no details. I can only suggest reading all ofthe post of the section and the best finding mistakes urseslf compare with other user's results

 

[Alchemistfromthahood]

Oh sry my mistake
I try to explain exaxtly next time

While I add hydrochloric acid (I stir throughout the entire precipitation process and I also used ice-cold acetone -20 degrees) the acetone/freebase mixture changes color I even think I found the error methylamine and 2b4m not fully reacted Blue-green spots remained in the reactor itself after the failure I have 1000 gr 2b4m, 5L ethyl acetate, 2L 50% caustic soda and 1500 gr. Methylamine HCL used The methylamine was added in 3x 500 g increments, which led to a prolonged reaction could probably be related to that

 

[rampage]

can methylamine aqueous 40% be used instead of methylamine hcl?

 

[Alchemistfromthahood]

For sure

 

[Alchemistfromthahood]

the proportions are not the same but for sure you can use

 

[agness]

I’ve recalculated proportion for 40% aq Methylamine but probably time of animation should be extended by 2-3h and Methylamine should be add in small portions.
Can someone confirm my conclusions?

 

[Dr. MMX]

With ethyl acetate you usually dont need to mind about temperature, depending on the scale,
if its up to 50c its fine

 

[Dr. MMX]

reaction time with aq is 20-30min, depending on the stirring and temp

 

[Kub@3552213]

Will there be anything with 3cmc synthesis?

 

[William Dampier]

You can use the method from this topic.

 

[nimrod313]

When I used this method and my rm was cold under 40⁰ my freebase was good and I got product when it heated 50-60⁰ I also got that red freebase
Since I always keep rm temp low

 

[William Dampier]

The temperature can be low if the stirring is poor. Or the concentration (%) of methylamine is low.

 

[nimrod313]

Honestly I prefer benzene and nmp my yield is higher
From 50ml 4mp I get 47g mmc powder

 

[agness]

Great. It Works!
Unfortunately I don’t have hcl but I used phosphoric acid 85
Salt is on the bottom but all liquid and 4mmc are green. Is it ok? What is the difference between those acid in final product?

 

[FQ-BB]

 

[William Dampier]

@agness
I have not had success with these salts. You can make a HCl generator from ophosphoric acid and NaCl.

 

[agness]

Ive got hcl finally
But it is 38%. Should I make it 10-15% or use as is?
Some other question:
1. 2b4m was not completely dissolved. Some very small part are in a bottom. I’ve filtered it but is it because of quality or should i add more etyl acetate?
2. Before acidification product should have 20-24c? In my last try I had 32c
3. Is there any chance to check when reaction with Methylamine is completed? Some sources said that 2-4h. But here I got 30min bellow 50c.
when I tried 3h a liquid changed a color to pale blue and finnaly I’ve got nothing.

Thanks!

 

[William Dampier]

You can dilute the acid if you want to get extraction into water. If you have a small amount of BK4 left, then do not worry, it will dissolve during the heating reaction process. Before acidification, it is better to cool the mixture, otherwise you can lose yield. If the reaction is warmed up, you do not need to keep a lot of time, you will lose the product. But if the heating does not occur, it is desirable to heat the reaction.

 

[handle]

Awesome, thank you for sharing this.
In step 6. Add methylamine HCL into flask Am i adding the methylamine HCl crystals? crystal / powder form?
Just thought id double check this first before i attempt.
Thanks again

 

[Dr. MMX]

Yes. You need to have flask with reaction and beaker with naoh water at room temp and methylamine hcl measured to be put in

Yes, methylamine hcl is in powder/crystals form.

 

[handle]

Thank you. sometimes reading all the posts can make things more confusing. ill try your method here first.
Try and keep it as simple as it is.

 

[Dr. MMX]

Its advized to read the whole process until every step is undersood. Its good practice - planning. If something goes wrong (if you will be confused during the process you may risk its success). If you do understand each step what to do it incrashes your chances for success

as well reading the book "lab techniques for begginers" contains priceless informations (I uploaded it into library)