Aminação de Leuckart da 1-fenil-2-propanona (P2P) para anfetamina e metanfetamina. Escala pequena.

[G.Patton]

Você usa condensador de refluxo e capela de exaustão?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[TheNut22]

Fiz meus peróxidos de hidrogênio mais fortes com H2O2 a 12%. Apenas evaporei cuidadosamente a água dele.
Solicitei cálculos ao assistente robô de IA em química. Ele é bom em cálculos, mas não espere obter respostas corretas
de halogenações ou similares ...

 

[loadingST]

Eu ainda não experimentei a reação, mas com uma boa hidrólise com KOH e depois com HCL, ela deve dar um alto rendimento, e tenho medo de trabalhar com h2o2 para não formar peróxidos explosivos e para não explodir após a destilação.

 

[William D.]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William D.]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking