1-fenil-2-propanon (P2P) Leuckartova aminizacija do amfetamina in metamfetamina. Smiselna lestvica.

[Selassi]

Plavalec je dobil vprašanje v zvezi z drugačno različico te metode:

Po prvem koraku (vrenju z mravljinčnikom in formamidom) zdaj organsko fazo namesto refluksa s HCl ponovno zavrejo z vodo in NaOH.

Ali mi lahko kdo razloži metriko tega drugačnega drugega koraka? Swim še nikoli ni delal na ta način, vendar se zdi, da prihrani veliko časa v nasprotju s staro metodo z refluksiranjem HCl.

Kakšna je moč jedke snovi/vode in koliko se je vnese v reaktor na L proizvoda?
Kako dolgo je treba kuhati to reakcijsko zmes pri kateri temperaturi?

 

[waltjr5858]

You can do hydrolysis with a base or an acid...

 

[Curiousonion]

Zakaj tako nizek izkoristek za to, ali ima kdo metodo z višjim izkoristkom za metamfetamin?

 

[Chemdog010297]

Red p, maybe aluminum

 

[Saul]

da ni prav narobe informacije, da diplomski fant dela velike napake

amonijev karbonat se nikoli ne uporablja neposredno s p2p.
Najprej se izdela amonijev format.
Amonijev format se enostavno izdela s pomočjo amonijevega karbonata in mravljinčne kisline. Titriranje
do pH 7 in odstranite vodo.
Šele nato se lahko uporablja s p2p

 

[waltjr5858]

Yes ammonium carbonate can completely be used in this reaction directly it's actually a very popular method in many countries and makes ammonium formate in situ.... if you're not 100% sure what you're saying on here don't

 

[G.Patton]

Ali uporabljate povratni hladilnik in digestor?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[waltjr5858]

Ok... but in general then what would happen to the resulting solution if spun up with 30% peroxide?

 

[William Dampier]

Uporaba dodatne količine vode v Leuckartovi reakciji lahko poveča izkoristek. Kdor je to storil, lahko o tem piše tukaj.

 

[TheNut22]

Ja. pri Leuckartu morate poskrbeti, da v njem sploh ni vode.

 

[southcost]

But we have a 12% water at least in our formic acid, isn't it?

 

[TheNut22]

Svoje močnejše vodikove perokside sem izdelal iz 12-odstotnega H2O2. Iz njega sem samo previdno izparil vodo.
Za izračune sem prosil pomočnika z umetno inteligenco - robota na področju kemije. Pri izračunih je dober, vendar ne pričakujte, da bo dobil pravilne odgovore
iz halogenacij ali podobnega ...

 

[loadingST]

Reakcije še nisem preizkusil, vendar bi z dobro hidrolizo s KOH in nato s HCL morala dati visok izkoristek, bojim pa se, da bi delal s h2o2, da ne bi nastali eksplozivni peroksidi, in da ne bi ob destilaciji eksplodirali.

 

[William Dampier]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William Dampier]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking

 

[waltjr5858]

I saw the same thing and nobody has an answer for it but it was done by actual professional chemist.... not clandestine hackers so id say its there for a reason but it will work without it. Probably to kill off so.e kind of side product or something.

 

[YenaneY]

I think it really is because the hydrogen peroxide helps promote the reaction, but the reaction of deformylation is generally easier on tertiary amines compared with secondary ones, which is why it happens more readily if N-methylformamide is used for methamphetamine.

 

[Pinkbay]

sir, In step 3, is heating required?

 

[rampage]

can you replace n-methylformamide with dimethylformamide?

 

[waltjr5858]

I don't think so