Metode ekstrakcije efedrina iz tablet

[G.Patton]

Ali ste razumeli, kar sem vam napisal zgoraj? To raztopino lahko poskusite raztopiti v vodi in ločiti od PEG z alkalno ekstrakcijo. Dobili boste toluen (ali drugo ustrezno topilo) s prosto bazo PseudoE). Nato s kislinsko ekstrakcijo izločite PseudoE iz Ibuprofena.

 

[waltjr5858]

He will get a massive emulsion because that peg is loading in their with a non ionic surfactant meant to encased anything in there as soon as the pH is raised...

 

[waltjr5858]

Peg blocks pseudoephedrine from going to non polar with help of usually polysorbate 80.... those need to go first. For anyone trying i would figure their solubility and get rid of as much of them as possible before adding any base...

 

[diogenes]

Pozdravljeni, Patton, zahvaljujemo se vam za pojasnilo. Moja zmeda je izhajala iz zapisa v Erowidu, kjer predlagajo, da se znebimo PEG z namakanjem začetne mešanice v toluenu, zato sem se začel spraševati, ali bo del PEG ostal v toluenu.

Tukaj je po mojem mnenju pravilen postopek, če bi kaj spremenili, mi prosim sporočite.

1. dodajanje alkalne raztopine do pH 13
2. ekstrakcija s toluenom/drugo nepolarno snovjo
3. odstranite staro vodno plast, nato pa morda naredite nekaj izpiranj z vodo?
4. Nepolarnemu topilu dodajte nekaj čiste vode.
5. Z razredčeno HCl dokisamo do pH 3
6. Pseudo bo migriral v vodno fazo kot sol pseudo-HCl
7. Ibuprofen (zdaj kisel) se bo obarjal v vodni fazi, tako da imamo teoretično v vodi precej čist psevdo.
(8.) Morda bi morala biti zadnja čistilna faza AB ekstrakcija z etrom, čeprav bi to lahko zmanjšalo izkoristek.

 

[Urky]

Žal mi je, da moram nekaj korakov razčistiti.

dodajanje alkalne raztopine na pH 13......... dodajanje alkalne raztopine na kaj? kot na primer dušenje tablet v alkalni vodi ? ker moje tablete vsebujejo sranje, ki se aktivira v vodi.
2. izvleček s toluenom/drugim nepolarnim.......dobrim
3. zavrzite staro plast vode, nato morda naredite nekaj pranj z vodo?........good
4. Nepolarnemu topilu dodajte nekaj čiste vode...........good
5. Z razredčeno HCl dokisajte do pH 3..........good
6. Pseudo bo migriral v vodno fazo kot sol Pseudo-HCl..........good
7. Ibuprofen (zdaj kisel) se bo obarjal v vodni fazi, tako da imamo teoretično v vodi precej čistega pseudo.............so Ibuprofen lahko zdaj filtriram iz vode in imam čisto vodo samo s pseudo?
(8.) Morda bi morala biti zadnja čistilna faza AB ekstrakcija z etrom, čeprav bi to lahko zmanjšalo izkoristek.

 

[waltjr5858]

Yes there has to be water present...if thats what your asking. I would selectively pull the peg and any other crap like that first otherwise you won't get freebase at all

 

[G.Patton]

Da, imate prav.

 

[labolita35]

Hi, how are you? I hope you're doing well. In the country I'm in, there are only a few over-the-counter medications that contain pseudoephedrine, and almost all of them are extended-release. I'd like to know if I can use any of the extraction methods described above. Here are the names and compounds. Thanks in advance.​

REACTINE:​

Active ingredients Each tablet contains: 5 mg of cetirizine 120 mg of pseudoephedrine Excipients Microcrystalline cellulose, lactose monohydrate, colloidal anhydrous silica, magnesium stearate, hypromellose (E-464), croscarmellose sodium, titanium dioxide (E-171) and polyethylene glycol 400.​

Gelocatil Gripe con Pseudoefedrina:​

Composition of GELOCATIL FLU WITH PSEUDOEPHEDRINE tablets Active ingredients: 500 mg of paracetamol, 30 mg of pseudoephedrine hydrochloride (equivalent to 24.57 mg of pseudoephedrine), and 4 mg of chlorphenamine maleate (equivalent to 2.81 mg of chlorphenamine). Other ingredients (excipients): microcrystalline cellulose, corn starch, povidone, talc, magnesium stearate, and purified water.

Thanks

 

[Joyboy56]

Ali lahko za ekstrakcijo klorfeniramin maleata in psevdogena uporabim 2. metodo ?

 

[waltjr5858]

Are these methods still good or have things changed. The problem inactives that is see in my pill in trying to extract is polyethylene glycol....polysorbate 80...and hypromellous... the rest of the stuff can be dealt with... there some wax also. Ill send a picture of the inactive ingredients. The pills are red 30mg film covered and it seems they dont have providone in them. The surfactant in there makes an absolute mess if you add base which I tried first the old normal way just to see what happens. I haven't tried doing this in awhile and the pills have definitely changed. Thanks if you can help.

 

[G.Patton]

Da, to morate najprej storiti vi. Ne vem, kje je vaša težava. Ne morem ugibati in vam odgovoriti brez vaše podrobne razlage postopka.
Ok, google: sestava nafte vm&p
nato morate izbrati enako ali podobno. Mislim, da je najboljši kerozin. Ali vidite, da morate samo uporabiti google in ga vprašati? To res dobro deluje za preprosta vprašanja, kot je vaše.

 

[waltjr5858]

The ones I am trying it seems to be magnesium sterate and stearic acid and anhydrous lactose that are causing crystallization issues. They seem to be tricky to get rid of

 

[Marvin "Popcorn" Sutton]

Sodeč po sestavi vaših tablet, ni potrebe po uporabi kislo-alkalne ekstrakcije. Poskusite tablete preprosto zdrobiti v prah in jih preliti s hladno vodo. Efedrin HCl bi se moral raztopiti. Nato filtrirajte netopno oborino in izparite vodo na krožniku, efedrin HCl bi moral tvoriti kristale.
Najprej pa določite natančno težo tablete, saj boste tako vedeli, ali so v sestavi še druge sestavine, ki niso navedene. Nato izberite metodo ekstrakcije.
Če potrebujete več podpore pri ekstrakciji, mi pišite na PM.

 

[unclefesteraddams8]

Thank you

 

[Osmosis Vanderwaal]

Samo... vau. ta nit je največje sranje na celotnem spletišču. Prepričala me je, da
T na tem svetu ni več nobenega ponosa. Zamenjala ga je ideologija "me too", v kateri je vsakdo žrtev vsega, kar lahko najde, da bi bil žrtev. Ta generacija je najbolj lena v zgodovini človeštva. Ko si lačen, iztegneš skledo in prosiš za hrano.
Ko te zebe mraz, iztegneš roko in prosiš za odejo. Komunizem. Zato nikoli ne deluje. Ker je bila odvzeta spodbuda, da se potrudiš. Ne glede na to, ali trdo delate ali sploh ne, bodo tisti, ki trdo delajo, prisiljeni podpirati tiste, ki ne delajo, in deliti sadove svojega dela z ljudmi, ki nočejo deliti delovnega bremena.
Ne zavidam ti @G.Patton, ti si edina delavna čebela, ki je pripela to nit in si odgovoril na verjetno več kot 100 vprašanj. Na nekatera ste odgovorili trikrat ali večkrat

 

[waltjr5858]

You aren't kidding...

 

[cisGafbdkodbkgbe]

Hi has anyone tried using an ion-exchange resin? Idea is from https://redd.it/886l5j
I'm no chemist and it sounds like magic. How does running pse, pill gak, water mixture through a dionizing resin extract pse^+ ions. Seems like you would run out of surface area and how is the resin ionically charged in the first place?

 

[waltjr5858]

Look up solid phase extraction. Don't use ion exchange... use filter designed specifically for your specific exipients to be removed.

 

[filekidb]

im new and dumb but, these are precursers correct? method 1 looks like meth? is it not?

 

[Idontcarethatmuch]

Maybe bc one way you do meth is from ephedrine tabs?

 

[filekidb]

yes

 

[qnbibiqn]

Can someone help with this type of pill. Since I know it can't be dissolved in water. They told me to dissolve it in alcohol and then I'm not sure. Is it toluene or what?
zyrtec-d The active substances are: cetirizine dihydrochloride and pseudoephedrine hydrochloride.

The other ingredients are:

Tablet core: hypromellose, microcrystalline cellulose, silicon dioxide, colloidal anhydrous, magnesium stearate, lactose monohydrate, croscarmellose sodium.
Film coating: Opadry Y-1-7000, which consists of: hypromellose (E464), titanium dioxide (E171), macrogol 400.
Zyrtec-D tablets are packed in blisters and placed in cardboard boxes. Each tablet contains 5 mg of cetirizine dihydrochloride with immediate release and 120 mg of pseudoephedrine hydrochloride with extended release.