Mephedrone (4-MMC) Synthesis [2B4M, Ethyl Acetate, Methylamine HCl]

[Pier]

Write on the bottles analytical reagent grade
It is a supplier of equipment for laboratories and chemicals My question is to buy something with high cleanliness or chemicals cheap for Industry

 

[Dr. MMX]

I can not suggest you that. It depends. You can get good reagents for good price, its not necesarry to obtain reagents for analytical purposes.

 

[Pier]

thank you for your help.

 

[Dr. MMX]

Yes this is very good reagent, to ensure maximum precise, but most important is 2b4m, rest matters less

 

[zetvasa9]

Hello, we have synthesized this method 3 times but we do not get more than 30% yield, what could be the problem? We follow the technology 1 in 1 as described in the guide

 

[handle]

Im going to try, No Acetone with the HCl acid , just dilute HCl Acid instead

 

[zetvasa9]

We have already tried this and it does not help to increase the output.

 

[handle]

we could try an alternate solvent like DMSO rather than Ethyl Acetate, maybe? IDK sorry.

 

[nimrod313]

WWork with dcm no more 38⁰

 

[handle]

I can never get it to 5.5 !! its always hangs around 7 - 8, then sometimes jumps straight up to 4...
So Annoying... by that time i think it has already mostly all come out of solution anyway, is there any point adding more HCl if solution has already precipitated? at 7 or 8?

 

[nimrod313]

Better make it 5-6 if you got salts dilute it for better stirr

 

[Pier]

hello can be used Erlenmeyer Flask 5000 ml for this synthesize or not ?​

Three necked round bottom Is it mandatory or not?​

 

[Dorov]

Can somebody help me personally to make a good product?
I will pay

 

[norivotset69]

are there any major differences when using 40% aq methylamine? 70g of it? does the reaction work same, duration etc?

 

[dnBQByvHb8Zkawbjpx]

You can use methylamine 40 % aq. instead of methylamine hydrochloride and NaOH+water solution. In my experience the reaction using 40 % aq is more exothermic compared to adding methylamine hydrochloride into the RM, so add it in portions and monitor the temperature of the RM so it does not go above the range that is best for your reaction and solvent of choice.

 

[norivotset69]

how long does the reaction works? Does the color change is the same like in te video? (brownish means complete)?

 

[dnBQByvHb8Zkawbjpx]

The rest of the reaction is the same and it's going to take the same amount of time as with methylamine hydrochloride, or less.

 

[Dr. MMX]

Precisely, for each mole of 2b4m is 2 moles of methylamine.

In the practice, yes you can do use about 135 ml of methylamine for 100g of 2b4m for the reaction.
You do not need to steps regarding usage of NaOH used to generate methylamine gas.

 

[norivotset69]

The reaction was takin about 8 hours (i still dont know how long should it last) and the color was dark dark turquise (visible through strong light). Changed to brown after rinsing with sodium bicarbonate. After rinsing I was left with 50ml of solvent (used 250 at the beggining). Is that solvent emulsified? I waited few minutes for every layer separation. Also liquid is then very dark color and when adding acid it doesnt change white but more of a yellowish milk coffee.

 

[zetvasa9]

Tell me, can the Methylamine that falls out as a solid precipitate be corrected again?

 

[handle]

Pretty sure there thats not methylamine and only minimal left after reaction has progressed to the end? IDK, someone can confirm.

 

[zetvasa9]

Hello, we have synthesized this method 3 times but we do not get more than 30% yield, what could be the problem? We follow the technology 1 in 1 as described in the guide. But the product comes out very good quality

 

[SpaceRocket]

I have the same problem !

 

[zetvasa9]

we were able to increase the output by up to 37%

 

[SpaceRocket]

what else did you do to get 37%?

 

[nimrod313]

Work with other solvent