The profitability of production is very high. With large scale synthesis, the cost per gram can be $3-4. A fair price varies from region to region, but it's usually around $30 per gram +-.
It is recommended for large scale synthesis to allow the bromine and the 4 Methypropiophenone to react with each other for large scale. Or can this synthesis also be used on a larger scale? since when combining the first thing I mentioned, you have to buy Methylene chloride for that. I see that here in this syntesis that is not used.
At 9:03, the instructions say to add "100mL 5% sodium hydrocorbonate..."
Am I to assume that the "sodium hydrocorbonate" is sodium bicarbonate AKA sodium hydrogencarbonate with the formula NaHCO3?
Also, how would this work if the benzene were replaced with dichloromethane?
At 9:03, the instructions say to add "100mL 5% sodium hydrocorbonate..."
Am I to assume that the "sodium hydrocorbonate" is sodium bicarbonate AKA sodium hydrogencarbonate with the formula NaHCO3?
Also, how would this work if the benzene were replaced with dichloromethane?
Yes, To make a 5% solution. Take one part by weight of powder and add it to 19 parts of water by weight of solvent. For example, dissolve 50 grams of sodium carbonate in 950 grams of water.
Are there options to use an other solvent than benzene?
I know the method using ethyl acetate, but I'm not sure if using this here would imply unwanted side reactions or not.
If There are other solvents possible beside EA of Benzene,
I'm all ears
Are there options to use an other solvent than benzene?
I know the method using ethyl acetate, but I'm not sure if using this here would imply unwanted side reactions or not.
If There are other solvents possible beside EA of Benzene,
I'm all ears
In this particular synthetis, could benzene be replaced by an other solvent which is easier to obtain? If so, which one(s), and does the amount change, instead of 600ml?
Kind regards.
o crap. why didnt i see above post earlier. i guess toulen is toulene, is that a 1 on 1 replacement option? does the same apply for DMSO? (which is way easier to obtain)