Amphetamine synthesis from P2NP via Al/Hg (video)

[HIGGS BOSSON]

The acid in the video is 6 degrees of pH. The synthesis I have exceeded this number by a lot, about 9 or 10 degrees. What is the correct way to reduce the acid to return to the required degree of 6 degrees of pH, knowing that I am a beginner in this field. Please explain the steps in an easier way, thank you

cyb3r0Replied in a private message

 

[cyb3r0]

Thank you for your reply, my friend. I have another question. Do I put amphetamine in a dry and dark place for how many hours? or day? And what after that? Thank you

 

[Marvin "Popcorn" Sutton]

Storing amphetamine is similar to storing medications: a dark, cool, dry place, in a container with no access to oxygen. In such stable conditions amphetamine is stored for a long time.

 

[cyb3r0]

After cleaning, the powder must be thoroughly dried from traces of solvents, and then packed in a vacuum bag and put away in a dark and dry place, you can in the refrigerator.

HIGGS BOSSONIs there another plan after drying the amphetamine in the fridge or is the job done?

 

[Marvin "Popcorn" Sutton]

After cleaning and drying, amphetamine is fully ready for use. And how to store it I wrote above.

 

[cyb3r0]

After cleaning and drying, amphetamine is fully ready for use. And how to store it I wrote above.

Marvin Popcorn SuttonThank you so much

 

[a_king]

hello every one i want to synthesis Crystal methamphetamin is there any method or video on how to do it.

 

[Honolulu98]

I have a question, how much purity should sodium hydroxide have? I am finding on the Internet 25% or 50%. I don't know if this would work

 

[ACAB]

In the video synthesis of amphetamine, reagents are used:
10 g 1-phenyl-2-nitropropene;
100 ml isopropyl alcohol;
50 ml glacial acetic acid;
50 g sodium hydroxide;
12 g aluminium (in the form of sliced household foil);
0.1g mercury nitrate;
2 ml sulphuric acid;
50 ml acetone.

Description of amphetamine synthesis video.
Before the start of the synthesis, the laboratory assistant prepared a solution of 10 g of 1-phenyl-2-nitropropene in 100 ml of isopropyl alcohol and 50 ml of acetic acid. Also, for the aluminium amalgam, 12 g of household aluminium foil was prepared, which was cut into small pieces with a paper shredder. It can be cut with scissors or torn by hand.

0:04-0:40 - Preparation of an aqueous solution of alkali. In this video, it was made in advance so that the solution cools down by the time the main reaction mixture alkalizes. Alkalinization proceeds with the release of heat, and if a fresh hot alkali solution is used, then the exothermic will be more pronounced and forced cooling of the reaction mass will be required.

0:46-2:36 - Amalgam of mercury nitrate. Amalgamated aluminium will reduce 1-phenyl-2-nitropropene to amphetamine. During the amalgamation reaction: little gas evolves, a grey precipitate is formed. It is important not to miss the moment when the aluminium is ready: this can be determined by the formation of a grey precipitate and by the increased gas evolution; this happens in 10-15 minutes after the load.
The water is drained without removing the gauze, the amalgamated aluminium is washed with two portions of cold water. It is worth paying attention to the release of gas bubbles: it is noticed that with the "correct" amalgam, these bubbles are small, and the colour of the liquid is darker; if the bubbles are large and the colour is light, and the reaction looks violent, the amalgam is bad. This is almost certainly due to a lack of mercury salt. Please note that mercury salts are poisonous.

2:37-4:28 - The most important part of the process is the reduction of 1-phenyl-2-nitropropene on aluminium amalgam. The reaction is exothermic, proceeds with abundant heat release. During the process, it is necessary to carefully monitor the temperature, in case of excessive overheating, to cool in an ice bath, it is allowed to add cold water to the flask. There are cases when the reaction does not start, in which case it is necessary to warm the reaction mass thoroughly, and with a properly prepared amalgam, the reaction begins. The reaction proceeds with the release of the smell of a boiling alcohol and acetic acid mixture. To capture vapours, a spherical irrigation condenser is used, the efficiency of which can be increased by connecting running cold water to it or simply pouring cold water into.

5:04 - You can rinse the flask with a little alcohol and rinse the unreacted aluminium with it to collect residues and increase the yield.

5:13 - There should be little unreacted aluminium left. By the residues, you can determine the amount of 1-phenyl-2-nitropropene reacted.

5:16-6:13 - Alkalinization. The reaction proceeds with the release of heat. The remains of unreacted aluminium will additionally enter into reaction with alkali and heat the mixture, as well as create by-products.
In the process of allowing the mixture to rest after alkalinization, separation into visible layers occurs within 30 minutes. The pH of the top layer should be 11-12.

6:18-7:23 - Decantation: collect the top layer containing amphetamine base in alcohol. It can be dried a little with anhydrous magnesium sulfate, and the slag can be additionally extracted with a non-polar solvent (ether, benzene, toluene), the solvent is then evaporated.

7:24-8:50 - Preparing a solution of sulphuric acid in acetone. It is made softer acidification of the product to be smoother. If concentrated sulphuric acid is used, there may be local over-acidification of the product.

8:51-10:53 - Product acidification - obtaining amphetamine sulfate. To the upper yellow layer collected at the previous stage, a prepared solution of sulphuric acid is added dropwise. Flakes of salt will form with each drop. This stage is very important, it is necessary to carefully monitor the pH, avoiding over-acidification. Acidification is continued until pH 5.5-6 (neutral). The over-acidified product will be pinkish in colour. In case of global over-acidification, the product will be lost.

10:55-11:38 - Filtration of amphetamine sulfate from solvents in a Buchner funnel under vacuum. At this stage, the product can be additionally rinsed with cold acetone by pouring it through the funnel with the substance.

11:41-12:28 Filtration using improvised means. Any thick fabric can be used as a filter.
The resulting product is dried in a warm dry place for several hours to remove residual solvents. It is recommended to store it in a vacuum package.

The yield is 60-70%.

HIGGS BOSSONWhy is no water added before the alkanization and the remaining alcohol and a large part of the water distilled off again? Then alkali is added and the amphetamine is collected with a steam distillation and extracted with ether. Wouldn't this result in a cleaner product? Or rather, what is the objection to adding this step?

 

[Marvin "Popcorn" Sutton]

I have a question, how much purity should sodium hydroxide have? I am finding on the Internet 25% or 50%. I don't know if this would work

Honolulu98Are these aqueous solutions of sodium hydroxide? Show me the composition here.

 

[Marvin "Popcorn" Sutton]

Why is no water added before the alkanization and the remaining alcohol and a large part of the water distilled off again? Then alkali is added and the amphetamine is collected with a steam distillation and extracted with ether. Wouldn't this result in a cleaner product? Or rather, what is the objection to adding this step?

PennywiseThere is no such stage in this video. The video was taken from an open source and edited for our forum. But additional steps are not excluded and do not contradict this video. You can make a video of the step you care about and send it to us for posting with comments, or post it yourself.

 

[ACAB]

There is no such stage in this video. The video was taken from an open source and edited for our forum. But additional steps are not excluded and do not contradict this video. You can make a video of the step you care about and send it to us for posting with comments or post it yourself.

Marvin "Popcorn" SuttonYes, that is correct, but my question was rather meant to ask whether this step is unnecessary and thus does not result in any purification success, the yield drops very sharply or other disadvantages arise, or whether this additional step really improves the purity of the product. I did not want to criticize the video in its content.
Only to highlight this difference and test its sense.

 

[HIGGS BOSSON]

Yes, that is correct, but my question was rather meant to ask whether this step is unnecessary and thus does not result in any purification success, the yield drops very sharply or other disadvantages arise, or whether this additional step really improves the purity of the product. I did not want to criticize the video in its content.
Only to highlight this difference and test its sense.

PennywiseThe video presents a simplified version of the synthesis, excluding all procedures for additional cleaning and increasing yields. If desired, you can wash the amalgamma with water several times, additionally extract the base of the amphetamine with solvents, distill with the base vapor, do acid-base extraction and separation into isomers.

 

[ACAB]

The video presents a simplified version of the synthesis, excluding all procedures for additional cleaning and increasing yelds. If desired, you can wash the amalgamma with water several times, additionally extract the base of the amphetamine with solvents, distill with the base vapor, do acid-base extraction and separation into isomers.

HIGGS BOSSONYes of course there are many other steps that could be taken, just what all really makes sense? Is washing out the mercury salts with water really so good? Where to put the contaminated water? Then rather dispose of it later as a separated solid. The salts dissolve in water, not in ether, so the product will be completely without mercury, also a steam distillation separates the salts. I wonder if AB extraction is still needed after steam distillation and an acetone wash?
That is why I ask the questions.
Somewhere it was said that steam distillation makes the oil "long", that is, diluted and has less yield. I can not imagine that is correct, but maybe really 10% oil remains, because it is not completely carried along with the steam.
I am just trying to find information to become better.

 

[HIGGS BOSSON]

Yes of course there are many other steps that could be taken, just what all really makes sense? Is washing out the mercury salts with water really so good? Where to put the contaminated water? Then rather dispose of it later as a separated solid. The salts dissolve in water, not in ether, so the product will be completely without mercury, also a steam distillation separates the salts. I wonder if AB extraction is still needed after steam distillation and an acetone wash?
That is why I ask the questions.
Somewhere it was said that steam distillation makes the oil "long", that is, diluted and has less yield. I can not imagine that is correct, but maybe really 10% oil remains, because it is not completely carried along with the steam.
I am just trying to find information to become better.

PennywiseWhen I make amphetamine for myself, I thoroughly wash the amalgam from mercury salts with water, and carry out acid-base extraction, and then thoroughly wash the final product with acetone. I think this is enough and distillation with steam for those who like to bother with chemical processes.

 

[ACAB]

When I make amphetamine for myself, I thoroughly wash the amalgam from mercury salts with water, and carry out acid-base extraction, and then thoroughly wash the final product with acetone. I think this is enough and distillation with steam for those who like to bother with chemical processes.

HIGGS BOSSONThe first acid-base extraction is always necessary to get the amphetamine base (oil), I actually thought that after salting out there could also be a second AB extraction to purify the product.
So long thanks for the attention.

 

[Honolulu98]

Replied in a private message

HIGGS BOSSONCan you put the answer here? The materials are starting to arrive and I need all the information possible.

 

[HIGGS BOSSON]

Can you put the answer here? The materials are starting to arrive and I need all the information possible.

Honolulu98Remind me of your questions, I will answer here

 

[Honolulu98]

What is the Büchner measure of the video?

 

[Khaafii]

Nice, So this is for Speed with purity 70%?