Mephedrone synthesis (4-MMC) in NMP solvent. Large scale.

[Selassi]

We already did a succesfull synthesis of 3cmc. The help was greatly appreciated.

 

[Epikureetsdrug]

My congratulations, friend! You're the best! After such great success in subjugating substances, could you share with your fans your unique experience of this synthesis? because I've been trying for about a month to get a meager but successful result in 3cmc synthesis, but so far I've only had fiascos. I have already tried 5 different solvents, I personally dried acetone by distillation and with anhydrous magnesium sulfate, but after acidification and daily exposure of the glass with the product at -20⁰C, there was not even a hint of crystallization. Tell me the CAS number of the starting substance at the beginning, please?

 

[Venom2021]

methylene chloride is better in my opinion at 4mmc true 2h 40 ° but with 40 ° taulen it is too small the temperature must be higher than 50%, i.e. 100g bk4 50g 4mmc + a lot of impurities because you do not clean the oil at all I see after crystallization you will have somewhere 40g maybe less efficiency I obtained 70% and 80% yield on methylene chloride

 

[Epikureetsdrug]

my respect! could you share your unique experience of obtaining 70% yield in the synthesis of 4mmc in DCM? This is an extremely interesting result, at least for me. I will be very grateful to you for the enlightenment.

 

[rafael1985]

With 3 cmc you will be have more fun

 

[Epikureetsdrug]

I totally agree with you, friend. 3cmc somehow reminded me of a-pvp in terms of the method of isolation and crystallization. Due to the water in which hydrogen chloride is dissolved, they do not immediately crystallize from the solvent, but settle to the bottom in the form of an oily liquid. a-pvp is red, and 3cmc is radically black. Therefore, it is necessary to carefully decant the upper layer of the solvent and then rinse that viscous liquid with a fair amount of acetone, and almost immediately the substances precipitate. it remains only to filter and recrystallize.

 

[None]

I looked, there was no synthesis with permanganate and acetic acid.

 

[Epikureetsdrug]

Man, you're interested in the old method of making Jeff from ephedrine or pseudoephedrine by oxidizing it with potassium permanganate in an acidic environment, right? It's very simple. but wouldn't it be better to reduce it with hydrogen iodine in the presence of red phosphorus to methamphetamine? firstly, you will get high for longer, and secondly, this method is less harmful to health. If you are still curious about this, then write to me here in telegram: @placeres_prohibidos. I will help you solve these problems

 

[SonicNL]

Keton to methyl ratio is wrong. It should be 1:2 or a slight excess of methylamine. You used 1:1.6. Hope this awnsered your question. Maybe you also have errors in the synthesis but I wasn't there so I don't know.

 

[Charlie3]

but i follow according to the manual written. alright ill try increase methyl amount and see how the yield is. i followed exactly the steps in the video.

 

[Charlie3]

I have one question, is toluene a better substitute for benzene than EA, considering toluene is much more similar to benzene?

 

[HerrHaber]

no, not if you wish to obtain a rainbow confusion which turns more frustrating with every color change

 

[Charlie3]

Alright thanks

 

[nsrnsr]

I adjusted the pH to 3, no hydrochloride

 

[eddycordon]

How u do it ?

 

[Heineken]

we made new 4mmc thanks bb forum form help

 

[Epikureetsdrug]

Judging by this photo, buddy, you certainly have a talent for chemistry. Please accept my sincere congratulations. You are the best Bro and here is my first mephedrone cross. Only for some reason, chrome does not allow me to insert an image ... sad.

 

[Epikureetsdrug]

Salute sir William! I carried out the synthesis of 3cmc from 2Br-3Clpropiophenon CAS 34911-51-8 in strict accordance with this manual with the only difference that I used DMSO instead of NMP, but the result is still not satisfactory. A glass with a mixture of all the components specified in the manual, after acidification to pH=6, has been in the freezer for several hours at a temperature of -20⁰C, and no signs of crystallization are even observed. Only at the bottom of the glass does a radical black substance slowly collect, the consistency of which is very similar to used car oil. I have a question for all the experienced users of this Internet resource and in particular for the experts: what could be the reason for my failure, if the synthesis of 4MMC from BK-4 in simple DCM was successful and the yield was about 50%? I would be grateful for any rational and constructive explanation.

 

[Heineken]

because i need 2 solvate and u dont heat it

 

[Epikureetsdrug]

Excuse me sir. I misunderstood you: "Do you need two solvents?" and "I don't heat them?"... I have nothing against this, but please explain why it was said: to the synthesis of 3cmc using the 4mmc synthesis technology as presented by Sir William, or is it your personal, successful experience in obtaining 3cmc? the fact is that my native language is not English and I still use the services of third-party translators in communicating with foreigners, so it is quite possible that I misunderstood you. Do not take it for impudence, my request to explain your remark to my post. I will be sincerely grateful to you!

 

[flyhigh]

what is the yeild of mephedrone in grams with this process, using the amounts of as mentioned.

• 2-Bromo-4'-methylpropiophenone (cas 1451-82-7) - 5 kg;
• n-Methyl-2-pyrrolidone (NMP; cas 872-50-4) - 20 L;
• Methyl amine 40% aq. solution (cas 74-89-5) - 8 L;
• Benzene - 20 L;
• Acetone - 30 L;
• Hydrochloric acid con. aq. solution (HCl 36%) ~ 1.5 L;
• Distilled water - 20 L;
• Magnesium sulphate (MgSO4);

 

[Heineken]

if u made good 50%-60% - 20% when u made crystal

 

[Heineken]

and why u want use benzen if u use nmp ?XD

 

[Newbee]

Avoid benzene, use dcm instead.

 

[Newbee]

Read reagents section to mentioned synthesis.
Reagents:

• 2-Bromo-4'-methylpropiophenone (cas 1451-82-7) - 5 kg;
• n-Methyl-2-pyrrolidone (NMP; cas 872-50-4) - 20 L;
• Methyl amine 40% aq. solution (cas 74-89-5) - 8 L;
• Benzene - 20 L;
• Acetone - 30 L;
• Hydrochloric acid con. aq. solution (HCl 36%) ~ 1.5 L;
• Distilled water - 20 L;
• Magnesium sulphate (MgSO4);

 

[Heineken]

look video bro good