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GhostChemist

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Introduction

Amphetamine and methamphetamine are the most popular synthetic substances and both of them have significant value in modern drug sosiety. They are used at raves, parties, as doping, to get a high and so etc. BB Forum is unique platform in the World, which implements studies of these substances syntheses and post them publicly for free.

In this post, we want to share a comparation of several most popular syntheses methods of amphetamine and methamphetamine. All syntheses was conducted in one laboratory. You can compare their yield, reaction times, relative cost of product, syntheses pros and cons.

Comparative Characterization of Amphetamine Sulfate Synthesis Methods
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Method
Product
Reagents and materials
A difficulty of the method
The time required to obtain 100 g
Yield from theory (%)
Relative cost
per 100g
Advantages
Disadvantages
Аmph​
P2P; Al; HgCl2; NH3; H2O; EtOH or IPA; DCM; Acetone; Na2SO4; NaOH; H2SO4.
Reactor of appropriate volume with a reflux condenser (2-10 liters); ice bath; heater; beakers; filters; Separatory funnel; pH indicator paper​
Relatively simple​
1-1.5 d​
17-42%
851$​
Relatively available reagents; simple equipment; quick execution​
Small volume of P2P, maximum 100 g of P2P; high quality requirement for both the starting P2P and Al (minimum thickness of 14 µm); intense heating of the reaction mixture; possibility of overheating the reaction mixture and reducing yield; high likelihood of lab detection due to strong ammonia odor.​
Аmph​
P2P; Formamide or NH4HCO2; HCOOH; NaOH; HCl or H2SO4; DCM; Na2SO4; EtOH or IPA.
Reactor of appropriate volume with a reflux condenser (2-10 liters); heater; beakers; filters; Separatory funnel; pH indicator paper​
Medium​
1.5-2 d​
25%
560$​
Possibility of process scalability; wide temperature range.​
Very low yield; specific reagent formamide; contaminated product despite clean starting materials; lengthy process; high likelihood of lab detection due to strong ammonia odor​
Аmph​
Al; HgCl2; P2NP; Glacial acetic acid; NaOH; IPA or EtOH; H2O; DCM; Na2SO4; Acetone; H2SO4.
Reactor of appropriate volume with a reflux condenser (2-10 liters); ice bath; heater; beakers; filters; Separatory funnel; pH indicator paper​
Relatively simple​
1-1.5 d​
60-70%
281$​
High yield; relatively available reagents; simple equipment; quick execution​
Small mass of P2NP, maximum 100 g of P2NP; high quality requirement for the starting Al (minimum thickness of 14 µm); intense heating of the reaction mixture; possibility of overheating the reaction mixture and reducing yield; likelihood of lab detection due to the odor of acetic acid.​
Аmph​
Al; HgCl2; P2P; NH2OH*HCl; NaOH; IPA or EtOH; H2O; DCM; Na2SO4; Acetone; H2SO4.
Reactor of appropriate volume with a reflux condenser (2-10 liters); ice bath; heater; beakers; filters; Separatory funnel; pH indicator paper​
Relatively simple​
1-1.5 d​
36%
734$​
Relatively available reagents; simple equipment; quick execution​
Small volume of P2P, maximum 100-200 g of P2P; high quality requirement for both the starting P2P and Al (minimum thickness of 14 µm); intense heating of the reaction mixture; possibility of overheating the reaction mixture and reducing yield; high likelihood of lab detection due to strong ammonia odor.​
Аmph​
P2NP; NaBH4; IPA; CuCl2; NaOH; Acetone; H2SO4; H2O.
A reactor of the appropriate volume with a stirrer; heater; beakers; filters; Separatory funnel; thermometer; Vacuum pump; pH indicator paper​
Medium​
1-1.5 d​
60%
487$​
Scalability potential of process; high yield; relatively pure product; alcohol odor can be masked by using air fresheners​
Careful control of the initial exothermic process; specific reducing agent NaBH4.​

Comparative characterization of Methamphetamine hydrochloride synthesis methods
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Method
Product
Reagents and materials
A difficulty of the method
The time required to obtain 100 g
Yield from theory (%)
Relative cost
Advantages
Disadvantages
Meth​
P2P; Al; HgCl2; СН3NH2; H2O; EtOH or IPA; DCM; Et2O; Acetone; Na2SO4; NaOH; HCl gas.
Reactor of appropriate volume with a reflux condenser (2-10 liters); ice bath; heater; beakers; filters; Separatory funnel; pH indicator paper; HCl gas generator​
Relatively simple​
1-1.5 d​
36-69%
496$​
Relatively available reagents; simple equipment; quick execution.​
Small volume of P2P, maximum 100 g of P2P; source of methylamine; high quality requirement for both the starting P2P and Al (minimum thickness of 14 µm); potential for intense heating of the reaction mixture with large loads; possibility of overheating the reaction mixture and reducing yield; high likelihood of lab detection due to strong odor of methylamine.​
Meth​
P2P; N-methylformamide; 14% aq HCl or 44% aq H2SO4; NaOH; H2O; DCM; EtOH; HCl gas; Et2O.
A reactor of the appropriate volume with a stirrer; heater; beakers; filters; Separatory funnel; thermometer; Vacuum pump; pH indicator paper; HCl gas generator​
Medium​
2-2.5 d​
30-38%
851$​
Scalability potential of process; wide temperature range​
Low yield; specific reagent n-methylformamide; impure product despite using clean starting components; lengthy process; high likelihood of lab detection due to strong ammonia odor.​
Meth​
P2P; СН3NH2 non aq; IPA abs; SiO2; NaBH4; Na2SO4; DCM; NH4Cl; HCl gas; Et2O; NaOH.
A reactor of the appropriate volume with a stirrer; heater; beakers; filters; Separatory funnel; thermometer; Vacuum pump; pH indicator paper; ice bath; HCl gas generator​
Medium​
1.5-2 d​
50-79%
483$​
High yield, Scalability potential of process, relatively odorless​
Specific reagents: methylamine in anhydrous alcohol and sodium borohydride; moisture-protected reactor system; efficient cooling of the reaction mixture.​

Prices was calculated according to https://www.sigmaaldrich.com/
Prices for reagents are taken for packing 1l or 1kg.

Conclusion

As you can see, the numbers speak for themselves. A reagents availability and syntheses costs are essential characteristics. It is hard to overestimate this data. Every clandestine chemist, who has a plan to produce one of these substances, can evaluate their opportunities with help of these comparison tables and choose the suitable synthesis pathway. Then, they can open a synthesis tutorial and study all details. Part of these syntheses have video instructions.
 
Last edited:

Dr. X

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Аmph​
Al; HgCl2; P2P; Glacial acetic acid; NaOH; IPA or EtOH; H2O; DCM; Na2SO4; Acetone; H2SO4.
Reactor of appropriate volume with a reflux condenser (2-10 liters); ice bath; heater; beakers; filters; Separatory funnel; pH indicator paper​
Relatively simple​
1-1.5 d​
60-70%
281$​
High yield; relatively available reagents; simple equipment; quick execution​
Small mass of P2NP, maximum 100 g of P2NP; high quality requirement for the starting Al (minimum thickness of 14 µm); intense heating of the reaction mixture; possibility of overheating the reaction mixture and reducing yield; likelihood of lab detection due to the odor of acetic acid​
GhostChemistI just want to say that the reagents are wrong here. The reagents to make amphetamine from P2P, not P2NP, are added. If not fixed soon for people wondering here are the correct ones: Al; HgCl2 or Hg(NO3)2; P2NP; Acetic acid or Formic acid; IPA or EtOH; Distiled H2O; NaOH; Aceton; H2SO4 or H3PO4; MgSO4(Optional).
However, the link is correct and you can see the whole synthesis there or ask one of the professionals on the forum for help!
 

GhostChemist

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I just want to say that the reagents are wrong here. The reagents to make amphetamine from P2P, not P2NP, are added. If not fixed soon for people wondering here are the correct ones: Al; HgCl2 or Hg(NO3)2; P2NP; Acetic acid or Formic acid; IPA or EtOH; Distiled H2O; NaOH; Aceton; H2SO4 or H3PO4; MgSO4(Optional).
However, the link is correct and you can see the whole synthesis there or ask one of the professionals on the forum for help!
Dr. XThank you for your attention, the mistake has been corrected.
The reagents are indicated taking into account the experiments which were conducted.
 

Jordan Belfort

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why does Al/Hg say only max 100 grams ? you can do that reaction up to 200L a time..... and yield is just 80 percent with correct ratio's, especially if you use nitro as solvent and source of methylamine ofcourse it will mix much better because it DOESNT boil of the methylamine from your reaction as it GENERATES
 

Jordan Belfort

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why does Al/Hg say only max 100 grams ? you can do that reaction up to 200L a time..... and yield is just 80 percent with correct ratio's, especially if you use nitro as solvent and source of methylamine ofcourse it will mix much better because it DOESNT boil of the methylamine from your reaction as it GENERATES
Jordan BelfortMix better because it makes a aezotrope with the oil and methanol
 
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OrgUnikum

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When loading into 200l reactor, temperature control of this reaction will be inherently impossible, even with the use of refrigerants
GhostChemistThats nonsense. The P2P is added not at once but consecutively to the reaction and the speed of addition controls the temperature. Easy as pie. 80% yields and more are well possible. Same for NaBH4: The temperature is controlled by how fast this is added to the reaction. Also 80% and more on yields.
The Al/Hg for P2NP, Oxime and the variation using nitromethane instead of methylamine are another story though.
 

HerrHaber

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Helpful comparison indeed... given that reactions were performed by the same team using same reagents
 

HerrHaber

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Helpful comparison indeed... given that reactions were performed by the same team using same reagents
HerrHaberThis study needs to be applied even wider to the other products of great interest such as the cathinones, where it would also be of great interest to see the extent to which bothering to acylate toluene and best halogenation method.
 
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Frit Buchner

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No birch reaction? I wonder how synthing an ephedrine precursors to start would compare 🤔
 

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Frit Buchner

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Birch reaction will be later
GhostChemistI'm staring down the barrel of a birch-like reaction this minute and my hands are shaking because it could be end of me but I'm out of time and out if answers. How the hell is a pet plastic bottle going to hold 125 psi,? I don't need the blue so long as I have the bronze? I hope so because as a kid we used to put drain cleaner and foil balls in pop bottles and it was not an indoor past time
 
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