Synthesis of Phenylacetic Acid From Benzyl Cyanide (large scale)

WillD

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YiBrQSFtLu

Equipment and glassware:

Reagents:

  • Water 725 l;
  • Sodium hydroxide (NaOH) 75 kg;
  • Benzyl cyanide 300 kg;
  • Hydrochloric acid (HCl aq 37%) 70 l;
  • Activated carbon 14 kg;

Reaction Scheme
TFX7k9263g

Synthesis
1. Water 650 l and sodium hydroxide (NaOH) 75 kg are added into a batch reactor.
2. Stirring is turned on for 2 h.
3. Benzyl cyanide 300 kg is added into the reactor.
4. The reaction mixture is maintained to a temperature 100 ℃.
5. The reaction mixture is stirred for 9 h.
6. Water 75 l is added into the reactor.
7. The reaction mixture is cooled down to 20 ℃.
8. Hydrochloric acid (HCl aq 37%) 70 l is poured into the reaction mixture in order to reach pH 6, temperature 20 ℃ has to be maintained.
9. Activated carbon 14 kg is then added to the mixture.
10. The reaction mixture is heated to a temperature 65 ℃.
11. This temperature is maintained with stirring for 30 min.
12. The reaction mixture is then moved into crystallization dishes through a
nutsche-filter.
13. Than, cooled down to temperature 10 ℃.
14. At this temperature and stirring, phenylacetic acid is released by 37% hydrochloric acid at pH 1-2.
15. Phenylacetic acid crystallization takes about 2 h.
16. The reaction mass is moved to a centrifuge after crystallization, pressed and washed on a vacuum filter with cold water.
 
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Jack

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Can you post a link to the source of this information,
and what is the purpose of the activated carbon step? Is this personal experience?
 

WillD

Expert
Joined
Jul 19, 2021
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954
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Can you post a link to the source of this information,
and what is the purpose of the activated carbon step? Is this personal experience?
JackThere is no article on this subject, this is a production moment. If you are interested in practicing this synthesis, I will help.
 
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