Σύνθεση αμφεταμίνης μιας κατσαρόλας από P2NP με NaBH4/CuCl2 (κλίμακα 1 kg)

[SelfExper1menter]

Γεια σε όλους. Προσπάθησα να φτιάξω λίγη αμφεταμίνη χρησιμοποιώντας αυτή τη συνταγή σε μικρή κλίμακα, αλλά απέτυχα. Όλα φαίνονταν εντάξει, μετά την ξήρανση το προϊόν μου έμοιαζε με λευκή σκόνη με μια απόχρωση ερυθρότητας. Αν επρόκειτο για θειική αμφεταμίνη (την οποία προσπαθούσα να φτιάξω), η απόδοση θα ήταν 84%. Το πρόβλημα είναι ότι δεν πρόκειται για αμφεταμίνη.

Φυσιολογικές επιδράσεις
Δοκίμασα 20-30 mg, υπήρξε σίγουρα διέγερση, αλλά επίσης προκάλεσε πυρετό και, προφανώς, μείωση της ανοσίας: και τις δύο φορές που το πήρα για αρκετές ημέρες στη σειρά, αρρώστησα με λοιμώξεις του αναπνευστικού (την πρώτη φορά νόμιζα ότι ήταν σύμπτωση). Ένα άλλο άτομο που το πήρε δεν είχε βιώσει καμία διέγερση από έως και 90 mg, μόνο κάποια ξηρότητα στο στόμα. Κανείς από τους δύο μας δεν έχει ανοχή στα διεγερτικά.

Χημικές δοκιμές
1 g σκόνης διαλύεται πλήρως σε 10 ml H2O.
Όταν πρόσθεσα περίσσεια διαλύματος NaOH σε μια μετρημένη μάζα της σκόνης σε δοκιμαστικό σωλήνα, πήρα έναν περίπου σωστό όγκο ελεύθερης βάσης που μύριζε αμμωνία. Διαχώρισα το στρώμα της ελεύθερης βάσης, το στέγνωσα με CaCl2 και προσπάθησα να το τιτλοδοτήσω με οξύ. Ως αποτέλεσμα, μέτρησα τη μοριακή μάζα της ελεύθερης βάσης να είναι περίπου 171 (και για την αμφεταμίνη είναι 135). Αν και οι μετρήσεις μου δεν ήταν πολύ ακριβείς, η διαφορά εξακολουθεί να είναι πολύ μεγάλη για να εξηγηθεί μόνο από σφάλματα μέτρησης.

Οι αποκλίσεις μου από τη διαδικασία
1) Κατά την προσθήκη του P2NP, συνειδητοποίησα ότι θα έπαιρνε ώρες, οπότε ανυπομονούσα και βύθισα τη φιάλη αντίδρασης σε υδατόλουτρο θερμοκρασίας δωματίου. Μετά από αυτό μπόρεσα να προσθέσω το P2NP σχεδόν όλο μαζί και η θερμοκρασία του μίγματος δεν ξεπέρασε τους 40-50 °С.
2) Ακολουθούσα το βίντεο, οπότε δεν εξατμίσαμε το IPA και πρόσθεσα απευθείας conc. θειικό οξύ στο στρώμα IPA/freebase.
3) Δεν είχα εκείνη τη στιγμή ακετόνη, οπότε δεν την πρόσθεσα πριν από την οξίνιση και ξέπλυνα τη φιλτραρισμένη πάστα "θειικής αμφεταμίνης" με IPA.
4) Το IPA είναι λιγότερο πτητικό από την ακετόνη, οπότε έπρεπε να βάλω το ίζημα μου σε φούρνο για αρκετές ώρες για να στεγνώσει σε σταθερό βάρος. Η θερμοκρασία στο φούρνο δεν ξεπερνούσε τους 80 °С.

Έτσι, το μεγάλο ερώτημα είναι, πού πήγε στραβά; Δεν θα με εξέπληττε μια χαμηλή απόδοση ή καθόλου προϊόν, αλλά να πάρω μια καλή απόδοση μιας αμίνης που δεν είναι αμφεταμίνη;!

 

[OrgUnikum]

The method as described here lacks all product workup/cleanup and and as such provides a very dirty and unclean Amphetamine, in special as NasBH4 reductions are all not giving very clean product. Purple MDMA and such.
I know the physiological effects like fever like very well and it is just the missing cleaning trust me.
There are several ways to do the workup, from distillation, normal, vacuum or steam of the base or dissolving the sulfate in water and washing this several times with toluene or petrolether or my favorite: 50/50 mix of petrol ether and Ethylacetate. Then evaporate the water and wash the resulting salt with copious amounts of Acetone and petrol ether as last. Already the simple washings give you a consumable product which does not make you sick like the crap which contains borate salts or else.

 

[waltjr5858]

Even with the dirtiest amp he would have felt it just fine....guaranteed he got "almost amp" mainly riddled with hydroxylamine. This reaction goes south on people all the time. They have wayyyy too much nabh4 left when it's time to add the copper and with the heat the nanoparticles aggregate and become completely useless as a catalyst....fully useless... and leave semi reduced product. The only way I've been able to get around that is by reducing 1st in methanol/thf to propane then extracting and then using anyone of the zinc/formic acid combos.... for the nitro. Zero Michael addition.

 

[Pajmon]

I tried it today, but something must have gone wrong..I followed the instructions exactly, but in the end there is more than there should be. What could have happened? Can anyone give me advice? Can it be cleaned? Thank you for every answer

 

[Pajmon]

Please. How do I have a reaction more nabh4? I threw in for 6 hours but still not much nabh4 dissolved. In the end, when I added acid, the whole thing thickened after filtration, a white substance remained, but I suppose it's nabh4.. I followed the instructions I don't know what's wrong.

 

[Swirly]

My mescaline guide might help for 1 or 2 mol amounts. Possibly up to 500 g+ in a 20 L reaction vessel.

The same procedure for P2NP as with Mescaline nitrostyrene, however I do not know if it is more reactive. Have not worked with it.

Take a look here:

Synthesis of Mescaline from 3,4,5-Trimethoxybenzaldehyde : SwirlyBird : Free Download, Borrow, and Streaming : Internet Archive

Detail of a chemistry experiment.

archive.org

https://archivep75mbjunhxc6x4j5mwjmomyxb573v42baldlqu56ruil2oiad.onion/details/mescaline-adventure_202507

Or posted here (if starting from benzaldehyde):

Mescaline Synthesis With Nitromethane. 1000g Scale.

https://www.sciencedirect.com/org/science/article/pii/S1860539725000040 Looked up using NaBH4 and CuCl2, instead of LAH and the paranoia of an incident, and this link is very specific in how it can be used for the 2,5 and the 3,4,5.

bbgate.com

 

[pureevil]

My friend and I always cooked amphetamine in the forest.
That is, for synthesis we really only needed 3 construction basins, Phenyl-nitropropene, several boxes of mercury thermometers, hydrochloric acid, gasoline and some special ribbons that show the reaction.

My role was always bring and serve, but we produced this product of 99.8% purity.
We had no competition in Moscow :/

we didn't use fucking acetone because it's bad for your health

 

[GhostChemist]

What is the salt of amphetamine present on this photos?

 

[pureevil]

sulfate

 

[pureevil]

At one point in Russia, they suddenly cut off the liquid propen supply—left a bunch of wannabe cooks totally clueless. Product turned out nasty as hell, colors ranging from sketchy pinks to filthy yellows and straight-up horrifying oranges. But my homie was different—he was one of the few who knew the synthesis inside and out. Back in the day, he cooked pristine pervitin for the whole block, but dude got busted—hit him with a solid 20-year stretch. Luckily there’s a war poppin' off, so he'll probably get tossed onto the front lines and bounce back home early. Then we'll pick right back up where we left off.

 

[GhostChemist]

but you say "...3 construction basins, Phenyl-nitropropene, several boxes of mercury thermometers, hydrochloric acid, gasoline and some special ribbons..." and in your list of reagents only hydrochloric acid

 

[pureevil]

That's right, dude.

 

[GhostChemist]

how could you get sulfate?

 

[pureevil]

I can hit him up and get the full cook recipe—it's fuckin' one-of-a-kind.

 

[GhostChemist]

in this synthesis using only this reagents "...Phenyl-nitropropene, several boxes of mercury thermometers, hydrochloric acid, gasoline and some special ribbons..." amp sulfate cannot be obtained.

with hydrochloric acid obtain amp hydrochloride
with sulphuric acid obtain amp sulphate

 

[G.Patton]

Your reagents list remind different synthesis way (Al/Hg approach). Why did you write this post under NaBH4 method? It's, also, interesting about HCl and sulphate salt.

 

[Pajmon]

Lately, I have not been able to get this reaction. I don't know what I'm doing wrong. Before that, I had better results. I always make only a lot of 10 grams, I don't know what I'm doing wrong, maybe someone can help. I have the ratio of substances as in the video, I use a half-liter flask with 3 holes - thermometer, cooler and hole where I put it. I use magnetic stirring. I think that's enough for that amount. In the first phase, my temperature is around 40-50 degrees, every time it starts to drop, I make a match. I tried 2 but also 4 hours with the same result. In the second phase, when I add a small amount, my temperature does not rise, as a result I have maybe half a gram. Before that, I used to have 5-6 grams. After adding H3PO4 drops, the whole thing thickened, now only a little bit is formed. I don't know what I'm doing wrong

 

[G.Patton]

Hi. Did you ad CuCl2 and reach this temperature?

 

[Pajmon]

yes, after adding CuCl2, I keep the temperature at 75-80 °C. When I did it before, it worked. I don't know where I'm making a mistake and why the yield is so small.. I'll try a different extraction method, I read somewhere here that it works without acetone

 

[Pajmon]

When I finish the first phase the temperature is around 50c. then I add CuCl2 but the temperature doesn't increase by itself I have to heat it up and I think the reaction is going on for a short time I follow it by the formation of bubbles but I don't know if that's right..otherwise everything looks like in the video. it happened to me but when I put a-oil in the freezer ice formed there so I think that in the phase when the hydroxide is added it didn't distribute as it should but I also don't know why..I'll try to buy another IPA, I used it differently than when I did it before. maybe that's the problem.. I'm most angry when I tried it the first time it worked much better

 

[G.Patton]

What color of your CuCl2?
>>but when I put a-oil in the freezer ice formed there
On a what step? Was it after acidification on Step 11? It's okay because your acid contains water. What pH have you reached?

 

[mile123]

Hello!

I built small version of batch chemical reactor that has 0.01C temperature precision, handle vacuum distillation while stirring, accurately add p2np in small portions using feeder, built from organic chemistry glassware. If you feed it with correct amounts and chemicals, it would produce without putting any additional effort.

I'm looking for a partner, who can get me chemicals in larger quantities, especially nitroethane. Chemical knowledge is also welcomed, since I'm mechanical engineer.
It would take me a lot of effort and energy to get the chemicals while I want to foucus on technology and product.

Send me dm if you are interested.