METHYLAMINE HYDROCHLORIDE (HCL)- is no joke

[EHRMANTRAUT]

!!!addendum: why else this article? the point is that at the stage of adding dissolved alkali to MA hcl I made a mistake. namely, I added it very quickly and as you have already realized the loss of quality of the aqueous methylamine and finally the poor quality yield of 4mmc.

 

[HeavenChem]

Bruh, you used too much of alkali
It can сreate regrouping free base to pyrazines because of instability of 4-MMC in alkaline solutions with oxygen.
Try to use an easy drawback of alkali to prevent side reactions

 

[HeavenChem]

Also you adding NaOH directly to methylamine salt. Better to prepare alkaline water solution and make it cold. Same need to do with water solution of your salt. In that case, after reaction you will get pretty good methylamine free base
Make sure what you using enough water, because sodium chloride can replace methylamine and your gas will be gone much faster

 

[CCL4 huffer]

honestly i dont get how methylamine HCl is that more acessible at that point just synthesise methylamine from nitromethane or acetamide.
bdw the spike in ph isnt the reason of loss of methylamine if u add to mutch base its simply heat generated by the reaktion thats why i would recomend if u would want to use this method that u add water to the methylamine HCl aswell and put it in a fridge till its nice and ice cold.

also just to say this method is barbaric contaminating the methylamine like that and then not eaven rl working it up like come on man is it realy so hard?
just use carbonate or bicarb instead of the hydroxide drip it in the methylamine HCl while heating it and bubble the methylamine trough ice cold water or very cold methanol ig. that method is mutch better and produces a pure solution.

but just simply contaminating methylamine with NaOH and NaCl is just barbaric.
atleast use a methylamine HCl excess so that its "only" contaminated with NaCl.
u should always go for the most purity possible eaven more so if the reagent will be used for drugs or something that is ment to be ingested.

so in conclusion no i wont like ur post.

 

[Cosa Nostra]

Can I replace Sodium Hydroxide with sodium bicarbonate in this reaction !? @CCL4 huffer

 

[Albert13]

Which carbonate or bicarb
do you mean?

 

[NucleuZ]

cool reagent