Síntesis de 4-MMC (mefedrona). Video tutorial completo.

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Ambos funcionan y ambos son buenos.
 

round2

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Hi Marvin
Great video and I have successfully synthesized 4mmc using this synthesis, thanks. Worked beautifully when acidified with hcl35 but using hbr48 turned out to be a disaster..is hbr not interchangeable with hcl for acidification of 4mmc in benzene?
 

round2

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Btw I used DMSO instead of nmp for the second round
 
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C10H11BrO + CH5N → C11H15NO + HBr
Como puede verse en la ecuación, una molécula de 2-bromo-4-metilpropiofenona produce una molécula de mefedrona.
C10H11BrO : 227,0977 g/mol
C11H15NO : 177,2429 g/mol
227.0977/177.2429=1.28127953
El coeficiente es 1.28127953
Esto significa que de 100 g de 2-bromo-4-propiofenona se obtienen 78,0469818 g de mefedrona base.

La masa del clorhidrato de mefedrona aumentará en 1,19 g/cm3 y el coeficiente será 1.27273446
C11H15NO+HCl=177.2429+1.19=178.4329
227.0977/178.4329=1.27273446

100g(C10H11BrO)/1.27273446=78.5709849g(C11H15NO)
El rendimiento teórico de la reacción de la 2-bromo-4-metilpropiofenona fue de 78,5709849g de clorhidrato de mefedrona. Pero hay que tener en cuenta que es difícil alcanzar el rendimiento teórico, normalmente la pérdida es del 20%.
 
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Bazooka90

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He encontrado un proveedor de 2-Bromo-4-Metilpropiofenona liquida pero no se como empezar desde este punto y cuanto liquido debo usar para hacer 100g de 4mmc.necesito algunos consejos.
 

Nsowonxmd

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Por bych. No. En un líquido. Bien. Peppercorn
 

William D.

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No está cualitativamente purificado, o tiene poco tiempo para la reacción. Se necesitan más detalles.
 

whitelabel

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Greetings

4mp to 4mmc successfully this way for me but starting 4mp was yellow so bromination done as per process.

Resultant mephedrone was a pasty powder and not crystal like salt as in video. Power was also low even after crystallization. Any thoughts on the pasty powder and low power. Yield was about 120 gms recrystallized from 400 ml 4mp.

Is there any way to purify the 4mp we get to start with or is that fine?

Would a superior product be possible if 4mp is brominated using NBs and PTSA, purified with a solvent nd then make the nmp synthesis from that 2b4m?

Thanks in advance. Tc
 

Tsigger

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No añadí acetona, sólo MMC freebase en benceno, y añadí HCl al 30% a pH 5,5. He añadido el ácido lentamente. ¿Podría ser la acetona el problema? Se me olvidó, porque normalmente acidifico con DCM+agua, así que la acetona no me vino a la mente. ¿Cómo acidificaste el bello de la foto? Muchas gracias.
 
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goatlabs666

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Gracias hermano
 

goatlabs666

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One question, im new in chemical. What Is NMP? Im sorry for the stupid question…
 

loadingST

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N-methyl-pyrrolidine and its toxic to the fertility be awere.
 

NieDoswiadczony

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  • WODA BROMOWA
  • Nazwa odczynnika (ang.): Bromine water
  • Gatunek: czysty
  • Wzór sumaryczny: Br2
  • Masa molowa [g/mol]: 159,82
  • Pojemność [ml]: 1000
  • Numer WE: 231-778-1
  • Numer CAS: 7726-95-6
  • Zawartość [%]: 4is it suitable for synthesis
 

had3s

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Awesome tutorial!

I have question. Can be this tutorial used for 3-CMC or 3-MMC?
 

Amorking

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had3s

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I'm using 2-bromo-4-methylpropiophenone for 4-MMC. What to use for 3-MMC?
 

dodobird

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@Marvin "Popcorn" Sutton can we scale this up using a 50litre batch reactor and drop the bromine Benzene mix from the reactors dropping funnel without any issues?
Bromine mix in an enclosed dropping funnel is a litle scary
 

santi

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dodobird

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Your reply is not clear please explain. What you said exactly
 

santi

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