I was having a convo with @Gordon Ramsay and @Heineken about 4-MMC and the topic of testing and quality came up so I wanted to start this thread to capture some of what I have found.
Looking at the massive variation in quality, look and feel, texture and dryness found across many vendors...
I've tried this synthesis and gotten yields ranging from 30% 45%. Sharing in case it might be helful to others. Vice versa, other people might know changes to this synthesis for higher yields.
Improvements are always welcome
100 g 2-bromo-4-methylpropiophenone
500 ml DCM
This video represent a simple synthesis way of 4-MMC (mephedrone) in a small scale from 4'-methylpropiophenone. There is total synthesis video manual which explain everything and gives opportunity to make 4-MMC to every beginner of organic synthesis.
Equipment and glassware:
We'll consider mephedrone (4MMC) synthesis in this article. Dichloromethane (DCM) is used as a solvent. It has a low boiling point (~40 °C) and synthesis procedures take a little time.
Air temperature 20-24 ºC;
Relative humidity <60%;
Well-ventilated room (with air...