Ephedrine extraction from pills methods

[G.Patton]

I think yes, you can try with small amount.

 

[sst]

I think yes, you can try with small amount.

G.Pattonhow much ammonia and sodium i need for every gram of pes hcl ?
can i use metal reaction vessel instead of glass i think its safer ?
i have ammonium sulfate is sodium hydroxide important to generate ammonia ?

 

[G.Patton]

how much ammonia and sodium i need for every gram of pes hcl ?

sstYou can count it in moles, you have to 1.5-2x excess of alkali to make alkaline space.

can i use metal reaction vessel instead of glass i think its safer ?

No, you can't. It will rust.

i have ammonium sulfate is sodium hydroxide important to generate ammonia ?

what?

 

[Maya]

Did you understand what I wrote to you above? You can try to dissolve this solution in water and divide from PEG by alkaline extraction. You will get toluene (or another appropriate solvent) with PseudoE free base). Then, acid extraction to divide PseiudoE from Ibuprofen.

G.Pattoncan I dissolve pills in methanol 99.9%at first and complet the steps?

 

[G.Patton]

can I dissolve pills in methanol 99.9%at first and complet the steps?

MayaProbably yes, I'm not sure. Better to use IPA.

 

[Maya]

Probably yes, I'm not sure. Better to use IPA.

G.PattonThanks

 

[Us3rn4m3]

Is this good? https://www.laboratoriumdiscounter.nl/en/xylene-isomers-98.html
Or do I need a specific isomer?

 

[robertlouis]

Hii Patron,

Sorry i dont really understrand specific extract ephedrine from NeoNapacin tablet also contains theophylline.
i have potreleum ether 90-120, NaOH, Hydrocloride Acid, Sulfuric Acid, Aquadest water, Isopropyle Alcohol.

Thanks

 

[robertlouis]

Hii @G.Patton ,

How to extract ephedrine HCL Salt from each pills contains Theophylline 130mg & Ephedrine HCL 12.5mg * 200 pills, Total 26 Grams Theophyline & 2.5 Grams Ephedrine HCL
my ready ingredients : NaOH, Isopropyle Alcohol 99%, Aquadest, Petroleum Ether 40-60, for HCL Gas i use NaCl, HCL Acid 35%, H2So4 (AR)

Thanks,
Sorry for many question about this, because 4 times i not yet get my expectation.

 

[G.Patton]

Hii @G.Patton ,

How to extract ephedrine HCL Salt from each pills contains Theophylline 130mg & Ephedrine HCL 12.5mg * 200 pills, Total 26 Grams Theophyline & 2.5 Grams Ephedrine HCL
my ready ingredients : NaOH, Isopropyle Alcohol 99%, Aquadest, Petroleum Ether 40-60, for HCL Gas i use NaCl, HCL Acid 35%, H2So4 (AR)

Thanks,
Sorry for many question about this, because 4 times i not yet get my expectation.

robertlouisHello, Robertlouis. Method is described in this post. What is a problem to repeat? Please, stop spam @G.Patton under each question.

 

[robertlouis]

Hello, Robertlouis. Method is described in this post. What is a problem to repeat? Please, stop spam @G.Patton under each question.

G.PattonOk Patron, sorry. I dont have much crystal yield when process bubbling HCL Gas, just 10% yield. Whers wrong? Do I have to separate theophylline first?

 

[robertlouis]

which best replacement VM&P naphtha?
-Kerosine
-Light Gas Oil
-Parafin
-thinner

because no Vm&P Naptha was found in my country, thanks

 

[G.Patton]

Ok Patron, sorry. I dont have much crystal yield when process bubbling HCL Gas, just 10% yield. Whers wrong? Do I have to separate theophylline first?

robertlouisYes, you have to do it firstly. I don't know where is your problem. I can't guess and answer you without your detailed procedure explanation.

which best replacement VM&P naphtha?
-Kerosine
-Light Gas Oil
-Parafin
-thinner

because no Vm&P Naptha was found in my country, thanks

Okay, google: vm&p naphtha composition

None reported [Note: VM&P Naphtha is a refined petroleum solvent predominantly C7-C11 which is typically 55% paraffins, 30% monocycloparaffins, 2% dicycloparaffins & 12% alklybenzenes.]

then, you have to chose same one or similar. I think Kerosine is best one. Do you see that you need just use google and ask it? It really works well for simple questions like yours.

 

[robertlouis]

Yes, you have to do it firstly. I don't know where is your problem. I can't guess and answer you without your detailed procedure explanation.

Okay, google: vm&p naphtha composition

then, you have to chose same one or similar. I think Kerosine is best one. Do you see that you need just use google and ask it? It really works well for simple questions like yours.

G.PattonOK, now I know where my problem is after reading a lot of your content patron. Thank you in advance. so my problem is that I don't know much about the acid-base theory to separate ephedrine from pills that also contain theophylline. okay which method is better for me to do? I have 2 methods in this content, I also have a method in the Fester Cookin Crank video. I've tried to follow the 2 methods in the fester video, but it only produces 1/5 of the total ephedrine hcl that I extract. short of knowledge, as far as i know only ephedrine hcl is soluble in water and theophylline is soluble in oil (non-polar). and after I finished this and got ephedrine hcl crystals, I will proceed to the reflux method with Hypophosphorus Acid + Iodine (these 2 ingredients is ready in my minilab). thank you very much. again each of my pills contains 12.5 mg ephedrine hcl & 120mg theophylline, I have 200 pills from each box. which method is good for me to start again with the hope of 100% results. I have prepared another 3 boxes of pills

 

[Marvin "Popcorn" Sutton]

OK, now I know where my problem is after reading a lot of your content patron. Thank you in advance. so my problem is that I don't know much about the acid-base theory to separate ephedrine from pills that also contain theophylline. okay which method is better for me to do? I have 2 methods in this content, I also have a method in the Fester Cookin Crank video. I've tried to follow the 2 methods in the fester video, but it only produces 1/5 of the total ephedrine hcl that I extract. short of knowledge, as far as i know only ephedrine hcl is soluble in water and theophylline is soluble in oil (non-polar). and after I finished this and got ephedrine hcl crystals, I will proceed to the reflux method with Hypophosphorus Acid + Iodine (these 2 ingredients is ready in my minilab). thank you very much. again each of my pills contains 12.5 mg ephedrine hcl & 120mg theophylline, I have 200 pills from each box. which method is good for me to start again with the hope of 100% results. I have prepared another 3 boxes of pills

robertlouisJudging by the composition of your tablets, there is no need to use an acid-alkaline extraction. Try just crushing the pills into a powder and pour cold water over them. The ephedrine HCl should dissolve. Then filter out the insoluble precipitate and evaporate the water on a saucer, Ephedrine HCl should form crystals.
But first, determine the exact weight of the tablet, this will let you know if there are other ingredients not listed in the composition. Then choose a method of extraction.
If you need more support with the extraction write me on the PM.

 

[robertlouis]

Judging by the composition of your tablets, there is no need to use an acid-alkaline extraction. Try just crushing the pills into a powder and pour cold water over them. The ephedrine HCl should dissolve. Then filter out the insoluble precipitate and evaporate the water on a saucer, Ephedrine HCl should form crystals.
But first, determine the exact weight of the tablet, this will let you know if there are other ingredients not listed in the composition. Then choose a method of extraction.
If you need more support with the extraction write me on the PM.

Marvin Popcorn SuttonI put cold water (distilled water), stir it up to 15-20 using a magnetic stirrer,

then filter it with a coffee filter, and the result is pink

and I evaporate it on a petri dish.

question:
a. why water turns pink
b. how long does evaporation take?
c. Which solution other than water crystallizes faster? what is petroleum ether? diethyl ether? ethanol ? methanol? teluene? isopropyl alcohol?
d. should I use the acid-base method using NaOH at the beginning and HCL Gas at the end? what I mean is like in the video Uncle Fester Cookin Crank

@G.Patton @HEISENBERG @William Dampier

 

[robertlouis]

Pill description:
Contains theophylline and Ephedrine HCL, used to relieve shortness of breath.

Composition:
Theophylline 130mg,
Ephedrine HCL 12.5mg

0.3 Grams the total mass of 1 pill I weighed.
msds not found.

 

[Chery]

Tell me who knows please, the free base of pseudoephedrine, what is the solubility in dichloromethane and is it possible to distill it in vacuum? Smooths like a sticky paste at room temperature, not oily.

 

[G.Patton]

Tell me who knows please, the free base of pseudoephedrine, what is the solubility in dichloromethane and is it possible to distill it in vacuum? Smooths like a sticky paste at room temperature, not oily.

ChernobaevHi, I think it is soluble in DCM. Not sure, but this solvent has close polarity as chloroform.

It is soluble in water, alcohol, chloroform, ether, glycerol, olive oil and in liquid paraffin.

is it possible to distill it in vacuum?

Yes

 

[Chery]

Мy favorite Actifet is no produced and I bought other pills with extended release tablets, when I filled them with alcohol, it turned out such a mess,

Starch... I thought and boiled this porridge in 5% sulfuric acid, thinking that it was possible to convert starch into glucose and oh gods the porridge turned into a liquid( foto 2)

Тhen I filtered everything and added sodium hydroxide ,and a strange plastic substance fell out, which I collected (photo 3) it tastes bitter like Еphedrine. what could it be? plasticizers?

 

[G.Patton]

Мy favorite Actifet is no produced and I bought other pills with extended release tablets, when I filled them with alcohol, it turned out such a mess,

Starch... I thought and boiled this porridge in 5% sulfuric acid, thinking that it was possible to convert starch into glucose and oh gods the porridge turned into a liquid( foto 2)

Тhen I filtered everything and added sodium hydroxide ,and a strange plastic substance fell out, which I collected (photo 3) it tastes bitter like Еphedrine. what could it be? plasticizers?

ChernobaevHi, have you checked melting point?