Ephedrine extraction from pills methods

[G.Patton]

Did you understand what I wrote to you above? You can try to dissolve this solution in water and divide from PEG by alkaline extraction. You will get toluene (or another appropriate solvent) with PseudoE free base). Then, acid extraction to divide PseiudoE from Ibuprofen.

 

[waltjr5858]

He will get a massive emulsion because that peg is loading in their with a non ionic surfactant meant to encased anything in there as soon as the pH is raised...

 

[waltjr5858]

Peg blocks pseudoephedrine from going to non polar with help of usually polysorbate 80.... those need to go first. For anyone trying i would figure their solubility and get rid of as much of them as possible before adding any base...

 

[diogenes]

Hi Patton, thank you for clarifying this. My confusion came from the Erowid write-up where they suggest getting rid of the PEG by soaking the initial mixture in Toluene, so I started to wonder whether some of the PEG will remain in the Toluene.

Here is the right process in my understanding, please let me know if you`d change something.

1. adding alkaline solution to pH 13
2. extract with Toluene/other non-polar
3. discard the old water layer, then perhaps do a few water washes?
4. Add some clean water to the non-polar solvent
5. Acidify until pH 3 with dilute HCl
6. The Pseudo will migrate to the water phase as Pseudo-HCl salt
7. The Ibuprofen (now acidic) will precipitate in the water phase so in theory we have pretty clean pseudo in the water.
(8.) Perhaps the final cleaning should be an AB extraction with ether although this could decrease the yield.

 

[Urky]

Sry i need to make few steps cleared.

adding alkaline solution to pH 13.........adding alkaline solution to what? like soke pills in alkaline water ? because my pills contain shit that activates in water.
2. extract with Toluene/other non-polar.......good
3. discard the old water layer, then perhaps do a few water washes?........good
4. Add some clean water to the non-polar solvent...........good
5. Acidify until pH 3 with dilute HCl..........good
6. The Pseudo will migrate to the water phase as Pseudo-HCl salt..........good
7. The Ibuprofen (now acidic) will precipitate in the water phase so in theory we have pretty clean pseudo in the water.............so I can filter ibuprofen out of the water now and have clean water with only pse ?
(8.) Perhaps the final cleaning should be an AB extraction with ether although this could decrease the yield.

 

[waltjr5858]

Yes there has to be water present...if thats what your asking. I would selectively pull the peg and any other crap like that first otherwise you won't get freebase at all

 

[G.Patton]

Yes, you are right.

 

[labolita35]

Hi, how are you? I hope you're doing well. In the country I'm in, there are only a few over-the-counter medications that contain pseudoephedrine, and almost all of them are extended-release. I'd like to know if I can use any of the extraction methods described above. Here are the names and compounds. Thanks in advance.​

REACTINE:​

Active ingredients Each tablet contains: 5 mg of cetirizine 120 mg of pseudoephedrine Excipients Microcrystalline cellulose, lactose monohydrate, colloidal anhydrous silica, magnesium stearate, hypromellose (E-464), croscarmellose sodium, titanium dioxide (E-171) and polyethylene glycol 400.​

Gelocatil Gripe con Pseudoefedrina:​

Composition of GELOCATIL FLU WITH PSEUDOEPHEDRINE tablets Active ingredients: 500 mg of paracetamol, 30 mg of pseudoephedrine hydrochloride (equivalent to 24.57 mg of pseudoephedrine), and 4 mg of chlorphenamine maleate (equivalent to 2.81 mg of chlorphenamine). Other ingredients (excipients): microcrystalline cellulose, corn starch, povidone, talc, magnesium stearate, and purified water.

Thanks

 

[Joyboy56]

Can i use 2nd method for extracting chlorpheniramine maleate and pse ?

 

[waltjr5858]

Are these methods still good or have things changed. The problem inactives that is see in my pill in trying to extract is polyethylene glycol....polysorbate 80...and hypromellous... the rest of the stuff can be dealt with... there some wax also. Ill send a picture of the inactive ingredients. The pills are red 30mg film covered and it seems they dont have providone in them. The surfactant in there makes an absolute mess if you add base which I tried first the old normal way just to see what happens. I haven't tried doing this in awhile and the pills have definitely changed. Thanks if you can help.

 

[G.Patton]

Yes, you have to do it firstly. I don't know where is your problem. I can't guess and answer you without your detailed procedure explanation.
Okay, google: vm&p naphtha composition
then, you have to chose same one or similar. I think Kerosine is best one. Do you see that you need just use google and ask it? It really works well for simple questions like yours.

 

[waltjr5858]

The ones I am trying it seems to be magnesium sterate and stearic acid and anhydrous lactose that are causing crystallization issues. They seem to be tricky to get rid of

 

[Marvin "Popcorn" Sutton]

Judging by the composition of your tablets, there is no need to use an acid-alkaline extraction. Try just crushing the pills into a powder and pour cold water over them. The ephedrine HCl should dissolve. Then filter out the insoluble precipitate and evaporate the water on a saucer, Ephedrine HCl should form crystals.
But first, determine the exact weight of the tablet, this will let you know if there are other ingredients not listed in the composition. Then choose a method of extraction.
If you need more support with the extraction write me on the PM.

 

[unclefesteraddams8]

Thank you

 

[Osmosis Vanderwaal]

Just...Wow. this thread is the biggest shit-show on the whole site. It's convinced me that
T there is no pride left in this world. It's been replaced with "me too" ideology where everyone is the victim of anything they can find to be victimized by. This generation is the laziest in the history of mankind. .When you Are hungry, , you hold your bowl out and beg for foid
When you are cold you hold your hand out And beg for a blanket. Communism. This is why it never works. Because the incentive to try hard has been taken. Whether you work hard or not at all, the ones working hard will be forced to support the non-workers and share the fruits of their labor with people who refuse to share the work load
I don't envy you @G.Patton, you are the one worker bee pin this thread and you've answered probably over 100 questions. Some you've answered 3 or more times

 

[waltjr5858]

You aren't kidding...

 

[cisGafbdkodbkgbe]

Hi has anyone tried using an ion-exchange resin? Idea is from https://redd.it/886l5j
I'm no chemist and it sounds like magic. How does running pse, pill gak, water mixture through a dionizing resin extract pse^+ ions. Seems like you would run out of surface area and how is the resin ionically charged in the first place?

 

[waltjr5858]

Look up solid phase extraction. Don't use ion exchange... use filter designed specifically for your specific exipients to be removed.

 

[filekidb]

im new and dumb but, these are precursers correct? method 1 looks like meth? is it not?

 

[Idontcarethatmuch]

Maybe bc one way you do meth is from ephedrine tabs?

 

[filekidb]

yes

 

[qnbibiqn]

Can someone help with this type of pill. Since I know it can't be dissolved in water. They told me to dissolve it in alcohol and then I'm not sure. Is it toluene or what?
zyrtec-d The active substances are: cetirizine dihydrochloride and pseudoephedrine hydrochloride.

The other ingredients are:

Tablet core: hypromellose, microcrystalline cellulose, silicon dioxide, colloidal anhydrous, magnesium stearate, lactose monohydrate, croscarmellose sodium.
Film coating: Opadry Y-1-7000, which consists of: hypromellose (E464), titanium dioxide (E171), macrogol 400.
Zyrtec-D tablets are packed in blisters and placed in cardboard boxes. Each tablet contains 5 mg of cetirizine dihydrochloride with immediate release and 120 mg of pseudoephedrine hydrochloride with extended release.