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  • 2-Bromo-4'-methylpropiophenone Detailed Guide


    2-Bromo-4′-methylpropiophenone is a representative of the haloketone class. 2-Bromo-4′-methylpropiophenone, also known as bromoketone-4, is a precursor for the synthesis of mephedrone. This article provides a comprehensive overview of 2-Bromo-4′-methylpropiophenone, including its general information, physico-chemical properties, chemical information, synthesis methods, concluding remarks, and bibliography.

    General Information About 2-Bromo-4′-methylpropiophenone

    Other synonyms names of 2-Bromo-4′-methylpropiophenone are: 2-Bromo-1-(p-tolyl)propan-1-one; 2-bromo-1-(4-methylphenyl)propan-1-one; 1-Propanone, 2-bromo-1-(4-methylphenyl)-; 2-bromo-1-(4-methylphenyl)-1-Propanone; 1-(4-methylphenyl)-1-oxo-2-bromopropane; 2-bromo-1-p-tolylpropan-1-one; 2-Bromo-p-methylpropiophenone; 4-Methylphenyl 1-bromoethyl ketone.

    2-Bromo-4′-Methylpropiophenone Structure

    IUPAC Name of 2-Bromo-4′-methylpropiophenone: 2-bromo-1-(4-methylphenyl)propan-1-one

    CAS Number: 1451-82-7

    Trade names: Bromoketone-4; b2k4; BK4.BK-4; 4-methyl-2-bromphenylethyl ketone; 4MBK; Bromoketon-4


    Powder and Crystalline Solid 2-Bromo-4′-methylpropiophenone

    Physico-Chemical Properties of 2-Bromo-4′-methylpropiophenone

    • Molecular Formula: C10H11BrO
    • Molar Weight: 227.10 g/mol
    • Boiling point: 274.57 ℃
    • Melting Point: 54.82 ℃ and 75 ℃ in Biosynth data
    • Index of Refraction: 1.552
    • Solubility: Water Solubility 89.6 mg/L at 25 ℃
    • Color/Form: solid.

    2-Bromo-4′-methylpropiophenone possesses a bromine atom at position 2 and a methyl group (-CH3) at the 4′-position on the aromatic ring. Derivatives of propiophenone are widely utilized in organic synthesis and can serve as precursors in the synthesis of various organic compounds. 2-Bromo-4′-methylpropiophenone is a chemical compound belonging to the phenol group. It is employed as a solvent in silicone rubber and functions as a colorant in plastics, paints, and enamels. Additionally, 2-Bromo-4′-methylpropiophenone has demonstrated effective antioxidant properties for china, silica gel, and silicone rubber. When heated, this compound produces a red color and can be used as a connector or monochrome panel on copper plates. Remarkably, this chemical has shown the ability to generate high-efficiency solar modules by converting sunlight into electricity.

    2-Bromo-4'-methylpropiophenone Synthesis Ways

    The synthesis of 2-Bromo-4′-methylpropiophenone is easily achieved by the simple bromination of 4′-methylpropiophenone with an equivalent amount of bromine, similar to the synthesis of bromopropiophenone.

    2-Bromo-4′-methylpropiophenone Synthesis

    Also, there is the way of 4'-methylpropiophenone bromination by hydrobromic (HBr) acid. Hydrobromic acid is more available and easy to handle for clandestine chemists than Br2.

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    2-Bromo-4'-methylpropiophenone Storage

    • Store in a well-ventilated place;
    • Store at 2°C - 8°C, close container well;
    • Stability ≥ 2 years;

    2-Bromo-4'-methylpropiophenone Toxicity and Rules for Handling

    Skin Irritation; Causes skin irritation; Eye Irritation; Causes serious eye irritation; May cause respiratory irritation.

    Precautions for safe handling

    • No special precautions are necessary if used correctly.
    • Avoid breathing dust/fume/gas/mist/vapours/spray.
    • Avoid prolonged or repeated exposure.
    • Keep away from sources of ignition.


    2-Bromo-4′-methylpropiophenone is a typical representative of the haloketone class, displaying the properties of both halogen-containing compounds and ketones. It is commonly used in organic synthesis and serves as a precursor for the synthesis of mephedrone. It is easily obtained through the bromination of the corresponding 4′-methylpropiophenone. It is commercially available under the name Bromketone-4.


    • https://pubchem.ncbi.nlm.nih.gov/compound/2-Bromo-4_-methylpropiophenone
    • https://en.wikipedia.org/wiki/Mephedrone
    • https://www.chemspider.com/Chemical-Structure.2015821.html?rid=9c60a7da-1f06-4135-bd31-7c043ae2926e
    • https://www.biosynth.com/p/FB19151/1451-82-7-2-bromo-4-methylpropiophenone
    • https://bbgate.com/threads/4-mmc-mephedrone-synthesis-complete-video-tutorial.616/
    • https://bbgate.com/threads/2-bromo-4-methylpropiophenone-synthesis-from-4-methylpropiophenone-bromination-in-dcm-or-gaa.210/
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