Síntesis de mefedrona (4-MMC) a partir de halocetona en acetato de etilo. Escala de 1-10 kg.

[yin-yang]

La N-metilacetamida debería ser soluble en acetona, aunque no he podido averiguar en qué medida. La base libre es efectivamente negra y el polvo resultante se vuelve verde al añadir la mezcla de disolvente cristalizante (¿cetona sin reaccionar?). Es seguro asumir que este no es el procedimiento más limpio.

Algunos juran que cualquier otra reaccion que no sea usando NMP como disolvente produce resultados muy, muy inferiores en el producto final. Es mas un colocon rapido sin euforia.

¿Hiciste un GC-MS para ver si hay impurezas en el polvo/cristales resultantes?
@G.Patton
@Marvin "Popcorn" Sutton
@William Dampier

 

[Wan Jack]

(6.The stirring is stopped. The reaction mixture is left for layer separations. A bottom layer is drained through a bottom reactor tap..)Because of the excess methylamine, the free base was washed more than 3 times with more than 2 times the deionized water.

 

[StarWars]

8. Después, la mezcla se calienta hasta 55
en el video dice claramente que no es necesario calentar. y aquí alguien escribió a continuación, calentar para lo que si la mezcla alcanza la temperatura en sí no superior a 65 °.

 

[G.Patton]

Hola, se necesitan 55 grados *C para evaporar al vacío los disolventes y el exceso de metilamina. Es un procedimiento opcional.

 

[goku1008]

can i skip this i dont have vacuum systume
and plz give me your screenshot video link plz

 

[G.Patton]

This video in the topic, dude...
Yes, you can separate layers without vacuum. There is this information in the screenshot.

 

[goku1008]

Stage 2
4. The stirring is stopped. The reaction mixture is left for layer separations. A bottom layer is drained through a bottom reactor tap.

I'm asking ethyl acetate is light solvent and 2b4m is heavy so why we need to drain bottom layer
If we drain bottom layer then only ethyl acetate left in flask
Help me on this plz plz

 

[goku1008]

stage 2
3. The mixture is stirred until complete amount of 2-bromo-4'-methylpropiophenone (cas 1451-82-7) is dissolved.
4. The stirring is stopped. The reaction mixture is left for layer separations. A bottom layer is drained through a bottom reactor tap.


my qustion is in video bro do this step after mixing water .but in method layer happen after 2-bromo-4'-methylpropiophenone dislove in ethyal cant understand this point

 

[G.Patton]

Hello, I edited the write up. You should separate layers at step 7.

 

[William D.]

When you received BK4, you must separate water with acid, which remained in the reaction mixture. To do this, we dissolve the BK4 and separate the residue of water.

 

[goku1008]

in vidoe after addingmethylamine 40% Colour change green red brown happened. Im asking is that same happen with 2b4m
also in video stating they said bk/ik .
is bk means 2b4m and ik mens 2i4m

 

[Naruto]

No

 

[goku1008]

then explain what is bk/ik ?

 

[Naruto]

Is other precursor and on 2b4m oil is yellow is is green then no all 2b4m work good

 

[G.Patton]

2-Bromo-4'-methylpropiophenone
2-Iodo-4'-methylpropiophenone
These are two different 4-MMC precursors. Please, look through the Methcathinones section topics before ask next question!

 

[William D.]

It is better to use 2br4mp, it is cheaper and gives a greater yield.