I can't extract pseudoephedrine dissolved in water

[Duart77]

Yesterday I bought a package of pseudoephedrine at the pharmacy so I saw it in the water to remove the other compounds, but when I had the pseudoephedrine dissolved in the water and put it on the stove the water evaporated and there was just a slime at the bottom of the pan.
what did I do wrong? Could it be that the fire was too high? Can someone help me?

 

[Throw-off]

It wouldn't be pure Susi pills its probably gak at the bottom, you can do an Acid base extraction and the susi will cone over in the non-polar solvent I recommend toluene.

 

[Duart77]

It wouldn't be pure Susi pills its probably gak at the bottom, you can do an Acid base extraction and the susi will cone over in the non-polar solvent I recommend toluene.

Throw-offI'm researching and found some methods that I liked thanks

 

[Throw-off]

I'm researching and found some methods that I liked thanks

Duart77Remember to make sure you check the PH if the Suzi is not alkaline to litmus you won't get anything back from your RM mixture once you reflux.

After you get your tolly from the AB what I usually do is steam destill it one more time so it is looking pure and clean before the hypo/I cook.. Its abit of a fuck around but its worth it so your not scratching your head wondering what went wrong down the track.

Remember external super steam. Quarter way down the Liebig.

 

[Duart77]

Remember to make sure you check the PH if the Suzi is not alkaline to litmus you won't get anything back from your RM mixture once you reflux.

After you get your tolly from the AB what I usually do is steam destill it one more time so it is looking pure and clean before the hypo/I cook.. Its abit of a fuck around but its worth it so your not scratching your head wondering what went wrong down the track.

Remember external super steam. Quarter way down the Liebig.

Throw-offunderstood. Just a question suzi is it pseudoephedrine?

 

[Frit Buchner]

trying to extract pseudoephedrine from pills using only water hasn't worked very well since about 1990. There are about a dozen different chemicals they add to pills to make that impossible. If you take a picture of the ingredient list we'll see which methods they are using in those specific pills and be able to suggest an extraction. There's also a thread on this forum that offers a few methods which work in most scenarios

 

[Duart77]

trying to extract pseudoephedrine from pills using only water hasn't worked very well since about 1990. There are about a dozen different chemicals they add to pills to make that impossible. If you take a picture of the ingredient list we'll see which methods they are using in those specific pills and be able to suggest an extraction. There's also a thread on this forum that offers a few methods which work in most scenarios

Frit BuchnerI heard about it but now I'm thinking about using A/B extraction

 

[Duart77]

trying to extract pseudoephedrine from pills using only water hasn't worked very well since about 1990. There are about a dozen different chemicals they add to pills to make that impossible. If you take a picture of the ingredient list we'll see which methods they are using in those specific pills and be able to suggest an extraction. There's also a thread on this forum that offers a few methods which work in most scenarios

Frit Buchnerthis is the composition of the tablets: Triprolidine hydrochloride 2.5 mg tablet + pseudoephedrine hydrochloride 60 mg Excipients: lactose monohydrate, starch, magnesium stearate, povidone and water.

 

[DirkDiggler]

You first have to make the pill water alkaline, preferably with NaOH.... PSE settles in solvent....then after filtering and cleaning whatever, the PH value is brought to the neutral state (PH6) using acid To get PSE from the solvent into a clean layer of water, which is obtained after evaporation.

There may be a few methods, but this is mine!

 

[Duart77]

You first have to make the pill water alkaline, preferably with NaOH.... PSE settles in solvent....then after filtering and cleaning whatever, the PH value is brought to the neutral state (PH6) using acid To get PSE from the solvent into a clean layer of water, which is obtained after evaporation.

There may be a few methods, but this is mine!

DirkDigglerbut is it efficient? and is it that simple?

 

[DirkDiggler]

but is it efficient? and is it that simple?

Duart77the more often you do this the more practice u`ll get.... its very simple... but check if there isn´t any bullshit in the pills witch make an EPH extraction unable....

 

[Duart77]

the more often you do this the more practice u`ll get.... its very simple... but check if there isn´t any bullshit in the pills witch make an EPH extraction unable....

DirkDigglerhttps://bbgate.com/threads/ephedrine-extraction-from-pills-methods.2443/

in my pseudo comes with some impurities I will try this first method in this video. Can you tell me if I can replace VM&P naphtha with mineral spirits?

 

[Duart77]

You first have to make the pill water alkaline, preferably with NaOH.... PSE settles in solvent....then after filtering and cleaning whatever, the PH value is brought to the neutral state (PH6) using acid To get PSE from the solvent into a clean layer of water, which is obtained after evaporation.

There may be a few methods, but this is mine!

DirkDigglerthese are the compounds in my medicine:Triprolidine hydrochloride 2.5 mg
Pseudoephedrine hydrochloride 60 mg
Excipients: lactose monohydrate, starch, magnesium stearate, povidone and water.

Do you think this method of yours works?

 

[Frit Buchner]

Ephedrine extraction from pills methods

Introduction It is totally OTC and uses activated carbon as a cleaning aide while exploiting characteristics of VM&P naphtha. Average yield is 60 % of very clean free base. Definitions In this write-up will be used the phrase "for every box of pills used". This stands for every box of 48 x 60...

bbgate.com

Method 2 resulted in some really beautiful crystals and about 75% efficiency on a first attempt. Less beer weed and shit like that could have probably got someone closer to 90%

 

[DirkDiggler]

Ephedrine extraction from pills methods

Introduction It is totally OTC and uses activated carbon as a cleaning aide while exploiting characteristics of VM&P naphtha. Average yield is 60 % of very clean free base. Definitions In this write-up will be used the phrase "for every box of pills used". This stands for every box of 48 x 60...

bbgate.com

Method 2 resulted in some really beautiful crystals and about 75% efficiency on a first attempt. Less beer weed and shit like that could have probably got someone closer to 90%

Frit BuchnerIf you work cleanly, without stress and with your head on the matter then you will get good results..... initially I had a maximum of 60% and when I learned how important cleanliness and careful work is, I got a maximum of 93%

 

[Duart77]

Ephedrine extraction from pills methods

Introduction It is totally OTC and uses activated carbon as a cleaning aide while exploiting characteristics of VM&P naphtha. Average yield is 60 % of very clean free base. Definitions In this write-up will be used the phrase "for every box of pills used". This stands for every box of 48 x 60...

bbgate.com

Method 2 resulted in some really beautiful crystals and about 75% efficiency on a first attempt. Less beer weed and shit like that could have probably got someone closer to 90%

Frit BuchnerI will try this method

 

[Raspberry2-3-4]

Is it not possible to extract from diet supplements containing ephedrine rather than tablets?

 

[Frit Buchner]

Is it not possible to extract from diet supplements containing ephedrine rather than tablets?

Raspberry2-3-4I would think so, there's no such thing in the US. I remember when they took them off the shelf it was a sad lazy day. Stackers and yellow jackets was breakfast and lunch

 

[Duart77]

Sorry for the delay, I had forgotten my account password.

 

[Duart77]

my tablets contain: Triprolidine hydrochloride 2.5 mg
Pseudoephedrine hydrochloride 60 mg
Excipients: lactose monohydrate, starch, magnesium stearate, povidone and water.

Can I remove pseudoephedrine just by adding ethanol and filtering and evaporating it?

 

[wael gano]

my tablets contain: Triprolidine hydrochloride 2.5 mg
Pseudoephedrine hydrochloride 60 mg
Excipients: lactose monohydrate, starch, magnesium stearate, povidone and water.

Can I remove pseudoephedrine just by adding ethanol and filtering and evaporating it?

Duart77Dissolve it in alkaline water, pH 12, then extract it with toluene or xylene
Then wash the toluene with water once, taking care that the alkalinity does not decrease. Then separate the toluene and pump hydrogen chloride gas into the toluene. The crystals of pseudoephedrine hydrochloride will fall. Filter the sediment and dry it.

 

[wael gano]

What do you mean by washing the toluene with water? I don't understand what you mean by this? Aren't they immisible?

Duart77After alkalinity is carried out, the pseudoephedrine base is dissolved in the toluene. Separate the toluene from the water, then add clean distilled water to the toluene and separate it a second time to remove the sodium particles. Then pump Hcl gas to the toluene. The pseudoephedrine Hcl salt will come out. Filter.

 

[Duart77]

After alkalinity is carried out, the pseudoephedrine base is dissolved in the toluene. Separate the toluene from the water, then add clean distilled water to the toluene and separate it a second time to remove the sodium particles. Then pump Hcl gas to the toluene. The pseudoephedrine Hcl salt will come out. Filter.

wael ganoThank you very much for your help friend. Do you know what yield this process is capable of generating?