The profitability of production is very high. With large scale synthesis, the cost per gram can be $3-4. A fair price varies from region to region, but it's usually around $30 per gram +-.
It is recommended for large scale synthesis to allow the bromine and the 4 Methypropiophenone to react with each other for large scale. Or can this synthesis also be used on a larger scale? since when combining the first thing I mentioned, you have to buy Methylene chloride for that. I see that here in this syntesis that is not used.
At 9:03, the instructions say to add "100mL 5% sodium hydrocorbonate..."
Am I to assume that the "sodium hydrocorbonate" is sodium bicarbonate AKA sodium hydrogencarbonate with the formula NaHCO3?
Also, how would this work if the benzene were replaced with dichloromethane?
At 9:03, the instructions say to add "100mL 5% sodium hydrocorbonate..."
Am I to assume that the "sodium hydrocorbonate" is sodium bicarbonate AKA sodium hydrogencarbonate with the formula NaHCO3?
Also, how would this work if the benzene were replaced with dichloromethane?
Yes, To make a 5% solution. Take one part by weight of powder and add it to 19 parts of water by weight of solvent. For example, dissolve 50 grams of sodium carbonate in 950 grams of water.
Are there options to use an other solvent than benzene?
I know the method using ethyl acetate, but I'm not sure if using this here would imply unwanted side reactions or not.
If There are other solvents possible beside EA of Benzene,
I'm all ears
Are there options to use an other solvent than benzene?
I know the method using ethyl acetate, but I'm not sure if using this here would imply unwanted side reactions or not.
If There are other solvents possible beside EA of Benzene,
I'm all ears
In this particular synthetis, could benzene be replaced by an other solvent which is easier to obtain? If so, which one(s), and does the amount change, instead of 600ml?
Kind regards.
o crap. why didnt i see above post earlier. i guess toulen is toulene, is that a 1 on 1 replacement option? does the same apply for DMSO? (which is way easier to obtain)
The profitability of production is very high. With large scale synthesis, the cost per gram can be $3-4. A fair price varies from region to region, but it's usually around $30 per gram +-.
Hello, can you please tell me if it is possible to synthesize on a scale of one kilogram with the same instructions? How long should the stirring or heating time be? If there is a specific point, I would appreciate it if you could let me know.
My first synthesis of mefedrone was semi sucesfull as i managed to synthesize it but I couldn't isolate it properly but since then I've identified the issue and I've managed to synthesize mefedrone with good,consistent high yields.
Hey guys i need some help with synthesis, would appreciate if you guys help me little bit, I'm a beginner at thie chemical thing but i think i understand 80% of this process for other 20% i need some help from you guy
My first synthesis of mefedrone was semi sucesfull as i managed to synthesize it but I couldn't isolate it properly but since then I've identified the issue and I've managed to synthesize mefedrone with good,consistent high yields.
My first synthesis of mefedrone was semi sucesfull as i managed to synthesize it but I couldn't isolate it properly but since then I've identified the issue and I've managed to synthesize mefedrone with good,consistent high yields.
I personally don't do the bromitation reaction I buy the 2-Bromo-4-Methylpropiophenone directly so I can only talk for the methylamination of the bromo ketone to which I don't apply any heat to as it would result in the 4MMC freebase degrading (reaction temperature should not exceed 60°C)
I personally don't do the bromitation reaction I buy the 2-Bromo-4-Methylpropiophenone directly so I can only talk for the methylamination of the bromo ketone to which I don't apply any heat to as it would result in the 4MMC freebase degrading (reaction temperature should not exceed 60°C)
If I’m skipping the beomination step and going with just
2-Bromo-4-Methylpropiophenone
How would this process change. Could I get away with 500ml of benzene since I only have 1 liter and how much
2-Bromo-4-Methylpropiophenone
Would I need to react with the 40% Methylamine in water in the benzene mixture and for how long?
I personally don't do the bromitation reaction I buy the 2-Bromo-4-Methylpropiophenone directly so I can only talk for the methylamination of the bromo ketone to which I don't apply any heat to as it would result in the 4MMC freebase degrading (reaction temperature should not exceed 60°C)
How much benzene should I add to the round bottom flask and how much
2-Bromo-4-Methylpropiophenone
do you put in the Benzene and how much Methylamine 40% in water do you add to that mixture? I to want to skip the bromination reaction as well. Any other advice you can give when doing it this way would be greatly appreciated
-thank you
How much benzene should I add to the round bottom flask and how much
2-Bromo-4-Methylpropiophenone
do you put in the Benzene and how much Methylamine 40% in water do you add to that mixture? I to want to skip the bromination reaction as well. Any other advice you can give when doing it this way would be greatly appreciated
-thank you
Hello, I personally use DCM+NMP for 10g of bromoketone I use 30-40ml of DCM(so that the bromoketone is fully dissolved )and 10 of NMP. As for the methylamine solution I use 15ml of 40%aq methylamine solution(if you chose not to use NMP then I'd go for about double the mass in mililiters so for 10g I'd use around 20ml)
Hello, I personally use DCM+NMP for 10g of bromoketone I use 30-40ml of DCM(so that the bromoketone is fully dissolved )and 10 of NMP. As for the methylamine solution I use 15ml of 40%aq methylamine solution(if you chose not to use NMP then I'd go for about double the mass in mililiters so for 10g I'd use around 20ml)
I’m following this video still using benzene because that’s what I already preferred but I’m skipping the bromimation step and wondering how much more bromoketome could I just add directly that would be more than the bromination process and then how much 40% Methylamine to add to as well and I am still going to use NMP since I’m new and I need the video for instructions and other people’s help lol
Hello, I personally use DCM+NMP for 10g of bromoketone I use 30-40ml of DCM(so that the bromoketone is fully dissolved )and 10 of NMP. As for the methylamine solution I use 15ml of 40%aq methylamine solution(if you chose not to use NMP then I'd go for about double the mass in mililiters so for 10g I'd use around 20ml)
Brother I really don't have any knowledge about chemical properties and their combinations will 2-bromo-4methylpropiophenone have same procedure and quantity as shown in video I I use it
The procedure starting from 4methylpropiophenone consists of two reactions: Halogenation(bromination) and amination and by buying the bromoketone directly you can skip the bromination reaction .
The procedure starting from 4methylpropiophenone consists of two reactions: Halogenation(bromination) and amination and by buying the bromoketone directly you can skip the bromination reaction .
